Treg-inducing membrane vesicles from Bifidobacterium bifidum LMG13195 as potential adjuvants in immunotherapy

Microbial Targets for the Development of Functional Foods Accordingly with Nutritional and Immune Parameters Altered in the Elderly

“…There is evidence of supplementation with probiotic strains increasing the levels of Clostridium clusters IV and XIVa or Bifidobacterium [43]. Indeed, it would be interesting to use certain strains, like B. bifidum LMG13195, which has recently been reported as an inductor of functional T regulatory cells [44,45]. These facts underline the possibilities for developing products specifically designated for the elderly population.…”

Extracellular vesicle–derived protein from Bifidobacterium longum alleviates food allergy through mast cell suppression

“…16 For example, DCs exposed to EVs of Bifidobacterium bifidum LMG13195 strongly promote differentiation of forkhead box protein 3 (Foxp3) 1 Treg cells. 17 Additionally, EVs of Staphylococcus aureus cause neutrophilic pulmonary inflammation through induction of T H 1 and T H 17 cell immune responses. 18 In a previous study, we isolated probiotics from fecal samples of healthy Korean neonates.…”

Protective Effect ofLaminaria japonicawith Probiotics on Murine Colitis

“…IL-10 was not elevated in our experiments, but several studies have reported that Lactobacillus , Bifidobacterium and Streptococcus species induce the production of anti-inflammatory IL-10, although with different effectiveness [42–44]. Thus, Bifidobacterium has been implicated in promoting T reg differentiation and programming T reg cells [45]. In our experiments, the measurements were performed only in intestinal mucosa at day 7 of DSS induction, when the differentiation or movement of T reg cells might not have been completed and T reg cells might still reside in submucosal layers.…”