Tree Pollen Allergy

Ne, Eriksson; Ja, Wihl; Arrendal, H.; So, Strandhede

doi:10.1111/j.1398-9995.1984.tb01981.x

Cited by 47 publications

(16 citation statements)

References 7 publications

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“…A majority of the subjects had higher specific IgE levels to rBetv 1 than to nQue a 1. It seems likely that these subjects have been exposed predominately to birch pollen and that the Que a 1 sensitization is the result of cross-reactive IgE antibodies originally developed against Bet v 1 [13, 14, 31]. Our cross-inhibition study using nQue a 1 and nBet v 1 supports the Bet v 1 cross-reactivity theory of acquiring Que a 1 sensitization in the 6 US and Swedish subjects studied.…”

Section: Discussionsupporting

confidence: 70%

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Purification and Characterization of the Major Oak Pollen Allergen Que a 1 for Component-Resolved Diagnostics Using ImmunoCAP®

Movérare

Everberg²,

Carlsson³

et al. 2008

Int Arch Allergy Immunol

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Background: The aim of this study was to purify the major oak pollen allergen, Que a 1, to perform biochemical and immunological characterization of the allergen and to develop an experimental native (n) Que a 1 ImmunoCAP®. Methods: Que a 1 was purified from oak pollen extract using affinity chromatography and characterized by SDS-PAGE, two-dimensional (2D) PAGE, mass spectrometry (MS), N-terminal sequencing and specific IgE inhibition on ImmunoCAP. Samples from 16 subjects sensitized to oak pollen were analyzed by ImmunoCAP for IgE reactivity to nQue a 1, and recombinant (r)Bet v 1 and 2 (profilin). They were also studied in IgE immunoblotting. Results: The purity of nQue a 1 was >95%, since a single band was observed on silver-stained SDS-PAGE. The identity was verified by MS analysis, and 2D-PAGE revealed several isoforms. The obtained N-terminal sequence of 50-amino-acid residues from nQue a 1 showed a 58–74% sequence identity with other pathogenesis-related class 10 allergens. Specific IgE inhibition verified a preserved immunoreactivity (70–92% inhibition). All subjects were sensitized to Que a 1 and Bet v 1, and two to profilin. The IgE antibody levels to nQue a 1 were generally lower than to rBet v 1. The obtained results correlated well with IgE immunoblotting. Conclusions: We present a highly purified and extensively characterized preparation of nQue a 1. Que a 1 seems to be an allergen of equal importance in oak pollen as Bet v 1 in birch pollen. An nQue a 1 ImmunoCAP will be useful in component-resolved diagnostics.

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Section: Discussionsupporting

confidence: 70%

“…In Madrid, Spain, 14% of the pollen-allergic patients are sensitized to oak pollen [12], and in Sweden this number is 70–80% of the springtime pollen-allergic patients [13]. Que a 1 is an important oak pollen allergen and belongs to the PR-10 protein family.…”

Section: Introductionmentioning

confidence: 99%

Purification and Characterization of the Major Oak Pollen Allergen Que a 1 for Component-Resolved Diagnostics Using ImmunoCAP®

Movérare

Everberg²,

Carlsson³

et al. 2008

Int Arch Allergy Immunol

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“…Pollens appear seasonally and are reflected in the symptoms of patients with SR living in temperate climates. Recent studies have shown that grass pollen in Turkey [4,5,6,7,8], birch and grass pollens in northern Europe [17,18,19,20,21], ragweed pollen in America [22], and mugwort and olive pollens in the Mediterranean area [23,24,25,26,27] are the most common and important allergens of these regions. Since Turkey is located between Europe and Asia like a bridge, all four seasons can be present in different regions of the country at the same time of the year.…”

Section: Discussionmentioning

confidence: 99%

Seasonal Rhinitis, Clinical Characteristics and Risk Factors for Asthma

Bozkurt

Karakaya²,

Kalyoncu³

2005

Int Arch Allergy Immunol

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Background: The aim was to determine the clinical characteristics of patients with seasonal rhinitis (SR) and to disclose differences in the treatment of SR between an adult allergy clinic and other clinics over time. Methods: A retrospective study was conducted based on clinical records of 774 out of 955 patients diagnosed with SR in an adult allergy clinic between 1 January 1991 and 31 December 2003. Results: The mean age of the patients was 29.1 ± 9.29 years and 62.7% were female. The most common major complaints of the patients were nasal symptoms in 82.3%. The mean duration of the disease was 6.76 ± 6.8 years. The patients were symptomatic with a mean of 3.5 ± 1.7 months a year, mostly during the period between April and July. Skin prick tests were positive in 685 patients (90.3%), where the most common sensitivity was against timothy grass (85.1%). The most common accompanying allergic diseases were food hypersensitivity in 14%, bronchial asthma in 13.4%, and drug allergy and/or intolerance in 9.6%. Although the use of specific immunotherapy and short-acting sedative antihistamines decreased over time, the use of nasal steroids and long-acting nonsedative antihistamines tended to increase before admission to our clinic. Older age (OR: 1.77, 95% CI: 1.06–2.94), presence of familial atopy (OR: 1.72, 95% CI: 1.04–2.85), respiratory symptoms (OR: 2.10, 95% CI: 1.75–2.50), ocular symptoms (OR: 0.77, 95% CI: 0.61–0.98) and metal allergy (OR: 0.25, 95% CI: 0.07–0.89) were associated with the development of asthma in patients with SR. Conclusion: SR lasts approximately 3.5 months and the main cause in Ankara, Turkey is grass pollen sensitivity. Patients with any other allergic conditions make up 39.8% of the patients. SR patients are referred to allergy clinics quite late, which might be due to SR not being considered as a serious disease.

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“…Consequently, the rate of sensitivity to grass and wild grass pollens is expected to be higher than tree pollens due to a more limited exposure. Also, it has been long known that although the concentration of tree pollens in the atmosphere is higher, their allergenicity is lower than that of grass pollens (30,31).…”

Section: Discussionmentioning

confidence: 99%

Sensitization Prevalence of Children with Allergic Rhinitis for Inhalant and Food Allergens in the Province of Sakarya, Turkey

Elmas¹,

Özdemir²

2017

JAREM

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Objective: Sensitization prevalence studies have been rarely reported in children with allergic rhinitis from different regions of Turkey, and the exact rates of some sensitizations in humid regions such as Sakarya are still unknown. The aim of this study was to explore what kind of allergens play a role in sensitizations of allergic rhinitis patients during childhood in the Sakarya province of Turkey.Methods: This cross-sectional study involves 623 patients, 1-18 years of age, who have allergic rhinitis symptoms and were referred to the only pediatric allergy outpatient clinic in Sakarya between May 2013 and June 2015. Firstly, a questionnaire containing demographic data and patient history was completed. The multiple skin prick test system was used to detect sensitization. With 0 x 0 mm negative control, any positive test result with an allergen was defined as a wheal ≥3 mm diameter.Results: Overall, 289/623 (46%) children showed a positive response. 37% of them were found to have multiple sensitizations. Among the 289 patients, there were sensitizations to pollens (252/289: 87%), mites (51%), grasses (66%), trees (21%), molds (8%), animals (6%), and foods (6%). Sensitizations above 5 years of age were as follows: grasses, 72% (168/233); mites, 49.4%; trees, 24.5%; molds, 6.9%; and animals, 6%. Under 5 years were as follows: mites, 59% (33/56); grasses, 42.9%; foods, 25%; molds, 10.7%; trees, 5.4%; and animals, 3.6%.Conclusion: There were significant sensitizations detected for pollens and mites. Overall, a lower sensitization (8%) to molds is found in our patients who were referred to us from the humid Sakarya province.

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Tree Pollen Allergy

Cited by 47 publications

References 7 publications

Purification and Characterization of the Major Oak Pollen Allergen Que a 1 for Component-Resolved Diagnostics Using ImmunoCAP®

Purification and Characterization of the Major Oak Pollen Allergen Que a 1 for Component-Resolved Diagnostics Using ImmunoCAP®

Seasonal Rhinitis, Clinical Characteristics and Risk Factors for Asthma

Sensitization Prevalence of Children with Allergic Rhinitis for Inhalant and Food Allergens in the Province of Sakarya, Turkey

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