Treatments of COVID-19-Associated Taste and Saliva Secretory Disorders

Tsuchiya, Hironori

doi:10.3390/dj11060140

Cited by 3 publications

(1 citation statement)

References 161 publications

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“…When demineralization prevails over remineralization, carious lesions occur which affect the tooth minerals promoting rapid dentin breakdown [ 6 ]. Dental caries increased during the COVID-19 pandemic among children due to their altered lifestyles to be more cariogenic with increased sugar consumption [ 7 ] also, postponed dental care, and the consumption of COVID-19 medications which causes xerostomia [ 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

Effect of N-Acetylcysteine on initial Carious Enamel Lesions in primary teeth: an In-vitro study

2023

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Background Dental caries initiates with non-cavitated enamel lesions as the first stage. The cariogenic potential of N-Acetylcysteine (NAC) may be due to its usage frequency and form. This study aimed to evaluate the impact of exposure time of NAC on initial enamel caries-like lesions in primary teeth by assessing the morphological alteration using a scanning electron microscope (SEM) and mineral content using energy dispersive x-ray spectroscopy (EDX). Methods Forty primary incisor teeth were randomly divided into 4 groups S, S1, S2, and S3 (10 specimens/group). Teeth crowns were cut from their roots and inserted into an acrylic mold with its buccal surface directed upward. Centrally isolated enamel window (2 × 2 mm) on the tooth was done. Ten specimens were selected to evaluate normal enamel while the remaining thirty specimens were immersed in demineralizing solution for 96 h to produce enamel caries-like lesions. PH cycling was performed by immersing each tooth sample in 20 mL of demineralizing solution for 3 h then, preserved for the remaining day hours in 10 ml of artificial saliva interspersed with treatments applications with 10 ml NAC for 10 min twice a day for one- or three-months different treatment modalities. Thermocycling was done for all specimens then they were subjected to SEM and EDX analysis. ANOVA and Bonferroni post hoc tests were utilized in data analysis. Results In teeth treated by NAC for 3 months (group-S3), SEM images showed severe loss of enamel architecture with large NAC deposits detected. A meaningful difference was observed among different groups concerning calcium, phosphorus, fluoride, ca/P ratio, carbon, nitrogen, and oxygen contents (P < 0.05). Conclusion NAC had a detrimental impact on enamel caries-like lesions in human primary teeth.

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Section: Introductionmentioning

confidence: 99%

Effect of N-Acetylcysteine on initial Carious Enamel Lesions in primary teeth: an In-vitro study

2023

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The long-term effect of COVID-19 infection on olfaction and taste; a prospective analysis

Boldes,

Ritter,

Soudry

et al. 2024

Eur Arch Otorhinolaryngol

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Purpose To estimate long-term prognosis of chemosensory dysfunctions among patients recovering from COVID-19 disease. Methods Between April 2020 and July 2022, we conducted a prospective, observational study enrolling 48 patients who experienced smell and/or taste dysfunction during the acute-phase of COVID-19. Patients were evaluated for chemosensory function up to 24 months after disease onset. Results During the acute-phase of COVID-19, 80% of patients reported anosmia, 15% hyposmia, 63% ageusia, and 33% hypogeusia. At two years’ follow-up, 53% still experienced smell impairment, and 42% suffered from taste impairment. Moreover, 63% of patients who reported parosmia remained with olfactory disturbance. Interestingly, we found a negative correlation between visual analogue scale scores for smell and taste impairments during the acute-phase of COVID-19 and the likelihood of long-term recovery. Conclusion Our study sheds light on the natural history and long-term follow-up of chemosensory dysfunction in patients recovering from COVID-19 disease. Most patients who initially suffered from smell and/or taste disturbance did not reach full recovery after 2 years follow-up. The severity of impairment may serve as a prognostic indicator for full recovery.

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