Treatment with stimulants and the risk of COVID-19 complications in adults with ADHD

Tuan, Wen-Jan; Babinski, Dara E.; Rabago, David; Zgierska, Aleksandra

doi:10.1016/j.brainresbull.2022.07.005

Cited by 4 publications

(3 citation statements)

References 37 publications

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“…102 Patients with attention deficit hyperactivity disorder (ADHD) who take non-stimulant medications (such as viloxazine, as well as atomoxetine, also clonidine, and guanfacine), have a cancer diagnosis or were in palliative care at all point before their index the COVID-19 virus. 103 Atomoxetine is, according to previous literature, remarkable growth in pulse as well as in blood pressure (BP). 104 In addition, COVID-19 patients typically take atomoxetine 10 mg once a day to treat their depression as well as attention deficit disorder, and the dose was gradually increased to 40 mg. 105 According to research, sodium acamprosate had a strongly prohibited task as opposed to 3CLpro from SARS-CoV-1, exposing an inhibition amount of more than 85%.…”

Section: Discussionmentioning

confidence: 99%

Molecular Biomarker Identification Using a Network-Based Bioinformatics Approach That Links COVID-19 With Smoking

Rahman

Amin

Yeasmin

et al. 2023

Bioinform Biol Insights

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The COVID-19 coronavirus, which primarily affects the lungs, is the source of the disease known as SARS-CoV-2. According to “Smoking and COVID-19: a scoping review,” about 32% of smokers had a severe case of COVID-19 pneumonia at their admission time and 15% of non-smokers had this case of COVID-19 pneumonia. We were able to determine which genes were expressed differently in each group by comparing the expression of gene transcriptomic datasets of COVID-19 patients, smokers, and healthy controls. In all, 37 dysregulated genes are common in COVID-19 patients and smokers, according to our analysis. We have applied all important methods namely protein-protein interaction, hub-protein interaction, drug-protein interaction, tf-gene interaction, and gene-MiRNA interaction of bioinformatics to analyze to understand deeply the connection between both smoking and COVID-19 severity. We have also analyzed Pathways and Gene Ontology where 5 significant signaling pathways were validated with previous literature. Also, we verified 7 hub-proteins, and finally, we validated a total of 7 drugs with the previous study.

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Section: Discussionmentioning

confidence: 99%

Molecular Biomarker Identification Using a Network-Based Bioinformatics Approach That Links COVID-19 With Smoking

Rahman

Amin

Yeasmin

et al. 2023

Bioinform Biol Insights

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“…No que diz respeito à otimização das intervenções medicamentosas, as dificuldades causadas pela pandemia do COVID-19 estão relacionadas com o fechamento das escolas e, consequentemente, a falta de relatórios escolares em que é dado o feedback dos alunos durante a titulação dos medicamentos, dificultando assim a avaliação dos efeitos do tratamento 2 . Indivíduos com TDAH apresentam taxas de infeção mais altas e piores resultados de Covi-19, contudo, quando em uso da medicação psicoestimulante está reduz os resultados negativos a saúde quando relacionados ao TDAH, bem como o risco de utilizar o departamento de urgência e serviços de terapia intensiva, contudo mais pesquisas precisam ser realizadas para confirmar e refinar esses achados 20 . Observou-se nos relatos de muitas mães a preocupação com o uso de medicamentos para o TDAH.…”

Section: Categoria 3: Implicações Entre O Diagnóstico Uso/não Uso De ...unclassified

Impacto do isolamento social em pessoas com “TDAH”

Cheffer

Lima

Zanella

et al. 2023

Saúde e meio ambient.: rev. interdisciplin.

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Objetivo: descrever o impacto do isolamento social causado pela pandemia da COVID-19 em indivíduos com Transtorno do Déficit de Atenção e Hiperatividade (TDAH). Métodos: A pesquisa foi desenvolvida na perspectiva da Antropologia Médica. A etnografia virtual foi eleita como metodologia de investigação e posterior análise de conteúdo. Participaram da pesquisa 15 grupos de TDAH, todos de acesso público na comunidade virtual Facebook e a coleta de dados ocorreu por meio de observação anônima no mês de junho de 2022. Resultados: emergiram três categorias: Dificuldades relatadas por mães de filhos com TDAH em comunidade virtual do Facebook durante o período de isolamento social causado pela COVID-19; Percalços na alfabetização de indivíduos com TDAH e Implicações entre o diagnóstico; uso/não uso de medicamentos psicotrópicos a partir de relatos das mães de filhos com TDAH. Conclusão: o isolamento social e o confinamento domiciliar afetaram negativamente a vida dos indivíduos com TDAH, bem como seu diagnóstico, tratamento e a continuidade do cuidado. O uso da tecnologia e das comunidades virtuais em redes sociais foi um grande alicerce de apoio e compartilhamento de informações nesse período. Palavras-chave: Transtorno do Déficit de Atenção com Hiperatividade; Metilfenidato; Covid-19; Isolamento Social.

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“…However, it was not clear if any potential confounders such as demographic and socioeconomic factors were accounted for in that study. ADHD patients who had stimulant treatment prescribed within the past year were found to have lower rates of healthcare encounter and mortality within 30 days of their COVID-19 infection compared to untreated patients ( Tuan et al, 2022 ). No other studies have directly examined the impact of ADHD or any current ADHD medication status on COVID-19 severity.…”

Section: Introductionmentioning

confidence: 99%

Association Between ADHD and COVID-19 Infection and Clinical Outcomes: A Retrospective Cohort Study From Electronic Medical Records

et al. 2022

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Objective: Though psychiatric illnesses have been associated with increased COVID-19 infection risk, limited information exists about the relationship between ADHD and COVID-19. Methods: Using the TriNetX COVID-19 Research Network, we examined the impact of ADHD diagnosis and treatment on COVID-19 infection rates and outcomes. Results: ADHD patients had greater risk of COVID-19 (risk ratio (RR) 1.11, 95% CI [1.09, 1.12]). Increased risk was higher in females than males, and highest among Asian and Black patients. Within 60 days after COVID-19 diagnosis, ADHD patients had lower rates of hospitalization (RR 0.91, 95% CI [0.86, 0.96]) and mechanical ventilation (RR 0.69, 95% CI [0.58, 0.83]), and a nonsignificant reduced death rate (RR 0.65, 95% CI [0.42, 1.02]). Patients who recently received ADHD medication had higher rates of COVID-19 (RR 1.13; 95% CI [1.10, 1.15]). Conclusion: ADHD poses increased risk for COVID-19, but may reduce risk of severe outcomes. ADHD medications modestly impacted COVID-19 risk.

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Treatment with stimulants and the risk of COVID-19 complications in adults with ADHD

Cited by 4 publications

References 37 publications

Molecular Biomarker Identification Using a Network-Based Bioinformatics Approach That Links COVID-19 With Smoking

Molecular Biomarker Identification Using a Network-Based Bioinformatics Approach That Links COVID-19 With Smoking

Impacto do isolamento social em pessoas com “TDAH”

Association Between ADHD and COVID-19 Infection and Clinical Outcomes: A Retrospective Cohort Study From Electronic Medical Records

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