Treatment with recombinant equine follicle stimulating hormone (reFSH) followed by recombinant equine luteinizing hormone (reLH) increases embryo recovery in superovulated mares

Meyers-Brown, Geraldine; Bidstrup, L.A.; Famula, Thomas R.; Colgin, M.; Roser, Janet F.

doi:10.1016/j.anireprosci.2011.09.002

Cited by 24 publications

(11 citation statements)

References 40 publications

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“…In equids, embryo production in vivo is limited because experimental induction of multiple ovulations has a low efficiency [10] and routine induction of multiple ovulations is still ineffective [6]. To our knowledge, no efficient superovulation treatment is available in the donkey.…”

Section: Introductionmentioning

confidence: 99%

Establishment of conditions for ovum pick up and IVM of jennies oocytes toward the setting up of efficient IVF and in vitro embryos culture procedures in donkey (Equus asinus)

et al. 2016

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Section: Introductionmentioning

confidence: 99%

Establishment of conditions for ovum pick up and IVM of jennies oocytes toward the setting up of efficient IVF and in vitro embryos culture procedures in donkey (Equus asinus)

et al. 2016

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“…Vários estudos vêm sendo realizados visando o aumento da eficiência reprodutiva das éguas, alguns deles com o uso de fármacos (Thompson e Witherspoon, 1974;Alcântara et al, 2005;Meyers-Brown et al, 2013) e de biotecnologias avançadas da reprodução equina (Coutinho da Silva et al, 2004;Meyers-Brown et al, 2011;Nagao et al, 2012 …”

Section: Introductionunclassified

Condição corporal e atividade reprodutiva de eguas

et al. 2014

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A manutenção dos animais em boa condição corporal é de grande importância para se alcançar altos índices reprodutivos, tanto à monta natural quanto frente às modernas biotecnologias da reprodução equina. A presente revisão de literatura teve como objetivo abordar a influência da condição corporal sobre a atividade reprodutiva de éguas, enfocando a atividade ovariana, o perfil endócrino, sendo dada ênfase à leptina, pois seus níveis estão diretamente relacionados à condição corporal e envolvidos no estímulo do eixo hipotálamo-hipófise-gônadas, e os índices de eficiência reprodutiva. Considerando uma escala de escore da condição corporal (1 a 9), éguas com escore > 5 são consideradas aptas a apresentarem índices de eficiência reprodutiva satisfatórios. Em síntese, a condição corporal exerce efeito sobre: a duração do anestro estacional e do período interovulatório, a secreção de IGF-1 e leptina, o número de ciclos/concepção, as taxas de prenhez, perda embrionária precoce e aborto. SUMMARYKeeping animals in good body condition is of great importance to achieve high reproductive rates, both the natural mating as the face of modern biotechnologies equine reproduction. This literature review aimed to evaluate the influence of body condition on reproductive activity in mares, focusing on ovarian activity, the endocrine profile, with an emphasis on leptin, because their levels are directly related to body condition and involved in stimulating hypothalamic-pituitary -gonadal axis, and the indices of reproductive efficiency.Considering a range of body condition score (1-9), mares with scores >5 are considered able to submit satisfactory levels of reproductive efficiency. Additionally, the body condition has an effect on the duration of seasonal anestrus, the interovulatory period, the secretion of IGF-1 and leptin, the number of cycles/conception, the pregnancy rates, early embryonic loss and abortion. INTRODUÇÃOEm um programa reprodutivo de equinos espera-se o nascimento de um potro saudável por égua, dentro do intervalo de um ano. Para isso, é necessário que se tenha éguas e garanhões de boa fertilidade, além de manejos reprodutivo, nutricional e sanitário adequados.Para a avaliação da fertilidade são adotados índices de eficiência reprodutiva, que refletem a fertilidade tanto individual como do plantel. Vários estudos vêm sendo realizados visando o aumento da eficiência reprodutiva das éguas, alguns deles com o uso de fármacos (Thompson e Witherspoon, 1974;Alcântara et al., 2005;Meyers-Brown et al., 2013) e de biotecnologias avançadas da reprodução equina (Coutinho da Silva et al., 2004;Meyers-Brown et al., 2011;Nagao et al., 2012

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“…In some cases, human embryonic kidney (HEK) cells have been chosen as a cell factory to produce bovine FSH (Nanocore Biotecnologia SA) used to supplement culture medium for in vitro follicle development in mares [29], dogs [30], goats, and sheep [31] (Table 1). The equine reproduction research industry has clearly been a user and promoter of this drug to stimulate follicular growth [6, 19, 32, 33] and ovulation [34] in mares. Even so, although the human version of this long-acting and single-chain FSH, Elonva (Corifollitropin α; MSD) was already available in 1992 [35–38], the bovine and equine analogs did not reach the market until 2008 [6].…”

Section: Recombinant Hormones In Reproductionmentioning

confidence: 99%

Trends in recombinant protein use in animal production

et al. 2017

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Recombinant technologies have made possible the production of a broad catalogue of proteins of interest, including those used for animal production. The most widely studied proteins for the animal sector are those with an important role in reproduction, feed efficiency, and health. Nowadays, mammalian cells and fungi are the preferred choice for recombinant production of hormones for reproductive purposes and fibrolytic enzymes to enhance animal performance, respectively. However, the development of low-cost products is a priority, particularly in livestock. The study of cell factories such as yeast and bacteria has notably increased in the last decades to make the new developed reproductive hormones and fibrolytic enzymes a real alternative to the marketed ones. Important efforts have also been invested to developing new recombinant strategies for prevention and therapy, including passive immunization and modulation of the immune system. This offers the possibility to reduce the use of antibiotics by controlling physiological processes and improve the efficacy of preventing infections. Thus, nowadays different recombinant fibrolytic enzymes, hormones, and therapeutic molecules with optimized properties have been successfully produced through cost-effective processes using microbial cell factories. However, despite the important achievements for reducing protein production expenses, alternative strategies to further reduce these costs are still required. In this context, it is necessary to make a giant leap towards the use of novel strategies, such as nanotechnology, that combined with recombinant technology would make recombinant molecules affordable for animal industry.

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Treatment with recombinant equine follicle stimulating hormone (reFSH) followed by recombinant equine luteinizing hormone (reLH) increases embryo recovery in superovulated mares

Cited by 24 publications

References 40 publications

Establishment of conditions for ovum pick up and IVM of jennies oocytes toward the setting up of efficient IVF and in vitro embryos culture procedures in donkey (Equus asinus)

Establishment of conditions for ovum pick up and IVM of jennies oocytes toward the setting up of efficient IVF and in vitro embryos culture procedures in donkey (Equus asinus)

Condição corporal e atividade reprodutiva de eguas

Trends in recombinant protein use in animal production

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