Treatment with Open Eyes: Markers‐Guided Chronotheranostics

Cornélissen, Germaine; Halberg, Franz

doi:10.1002/9780470498392.ch11

Cited by 11 publications

(6 citation statements)

References 77 publications

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“…Deviation from the norm by 1 or 2 additional features of blood pressure or heart rate variability raised 6-year morbidity from 9 to 29 and 53%, respectively [19] . Recognizing that different patients present with differently altered circadian profiles of blood pressure (chronodiagnosis), chronotherapy is best adjusted to the chronodiagnosis (chronotheranostics) [43] via truly personalized medicine, since the optimal treatment time differs from one patient to another, as demonstrated in a study by Watanabe et al [48] .…”

Section: Cornelissen/otsukamentioning

confidence: 99%

“…It thus seems mandatory to assess circadian variation as the indispensable control. Since differences in amplitude and/or acrophase are not necessarily accompanied by a difference in overall mean value (MESOR), sampling at a fixed clock hour can lead to spurious results [43] , as illustrated in online supplementary figure S6 for the case of 1-min time estimation by a clinically healthy man [44] . Circadian rhythmic change can be so large that in several self-measured variables it was more important than that associated with aging over an entire decade [45] .…”

Section: Rhythms As the Indispensable Controlmentioning

confidence: 99%

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Chronobiology of Aging: A Mini-Review

Cornélissen

Otsuka

2016

Gerontology

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Aging is generally associated with weakening of the circadian system. The circadian amplitude is reduced and the circadian acrophase becomes more labile, tending to occur earlier with advancing age. As originally noted by Franz Halberg, similar features are observed in the experimental laboratory after bilateral lesioning of the suprachiasmatic nuclei, suggesting the involvement of clock genes in the aging process as they are in various disease conditions. Recent work has been shedding light on underlying pathways involved in the aging process, with the promise of interventions to extend healthy life spans. Caloric restriction, which is consistently and reproducibly associated with prolonging life in different animal models, is associated with an increased circadian amplitude. These results indicate the critical importance of chronobiology in dealing with problems of aging, from the circadian clock machinery orchestrating metabolism to the development of geroprotectors. The quantitative estimation of circadian rhythm characteristics interpreted in the light of time-specified reference values helps (1) to distinguish effects of natural healthy aging from those associated with disease and predisease; (2) to detect alterations in rhythm characteristics as markers of increased risk before there is overt disease; and (3) to individually optimize by timing prophylactic and/or therapeutic interventions aimed at restoring a disturbed circadian system and/or enhancing a healthy life span. Mapping changes in amplitude and/or acrophase that may overshadow any change in average value also avoids drawing spurious conclusions resulting from data collected at a fixed clock hour. Timely risk detection combined with treatment optimization by timing (chronotherapy) is the goal of several ongoing comprehensive community-based studies focusing on the well-being of the elderly, so that longevity is not achieved at the cost of a reduced quality of life.

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Section: Cornelissen/otsukamentioning

confidence: 99%

Section: Rhythms As the Indispensable Controlmentioning

confidence: 99%

Chronobiology of Aging: A Mini-Review

Cornélissen

Otsuka

2016

Gerontology

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“…during the last week on that schedule (68). Underlying our recommendation to individualize the optimization by timing of the daily administration of antihypertensive medication is the concept of chronotheranostics, where the timed treatment is adjusted to the chronodiagnosis (14): if a patient has CHAT, treating at a circadian stage when the circadian amplitude of blood pressure is increased even further is likely to be harmful, even if the 24-h average pressure is lowered to a larger extent. This has been demonstrated in a double-blind crossover study that accounts for the difference in actual outcomes from two large clinical trials in Asia (60).…”

Section: Discussionmentioning

confidence: 99%

Diagnosing vascular variability anomalies, not only MESOR-hypertension

Halberg

Powell

Otsuka

et al. 2013

American Journal of Physiology-Heart and Circulatory Physiology

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Chronobiology is the study of biological rhythms. Chronomics investigates interactions with environmental cycles in a genetically coded autoresonance of the biosphere with wrangling space and terrestrial weather. Analytical global and local methods applied to human blood pressure records of around-the-clock measurements covering decades detect physiological-physical interactions, a small yet measurable response to solar and terrestrial magnetism. The chronobiological and chronomic interpretation of ambulatory blood pressure monitoring (C-ABPM) records in the light of time-specified reference values derived from healthy peers matched by sex and age identify vascular variability anomalies (VVAs) for an assessment of cardio-, cerebro-, and renovascular disease risk. Even within the conventionally accepted normal range, VVAs have been associated with a statistically significant increase in risk. Long-term C-ABPM records help to "know ourselves," serving for relief of psychological and other strain once transient VVAs are linked to the source of a load, prompting adjustment of one's lifestyle for strain reduction. Persistent circadian VVAs can be treated, sometimes by no more than a change in timing of the daily administration of antihypertensive medication. Circadian VVA assessment is an emergency worldwide, prompted in the United States by 1,000 deaths per day every day from problems related to blood pressure. While some heads of state met under United Nation and World Health Organization sponsorship to declare that noncommunicable diseases are a slow-motion disaster, a resolution has been drafted to propose C-ABPM as an added tool complementing purely physical environmental monitoring to contribute also to the understanding of social and natural as well as personal cataclysms.

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“…Such a difference had also been documented and tabulated for other agents, including drugs for high blood pressure (BP) [8, 9] and the irradiation of perioral tumors [10, 11] (Fig. 5–6), among many other treatments [12–15]. A start with nutriceuticals indicates that in a person investigated by varying the administration times of Coenzyme Q10 (CoQ10), the circadian stage played an important role (Fig.…”

Section: Introductionmentioning

confidence: 94%