Diagnosing vascular variability anomalies, not only MESOR-hypertension

Abstract

Chronobiology is the study of biological rhythms. Chronomics investigates interactions with environmental cycles in a genetically coded autoresonance of the biosphere with wrangling space and terrestrial weather. Analytical global and local methods applied to human blood pressure records of around-the-clock measurements covering decades detect physiological-physical interactions, a small yet measurable response to solar and terrestrial magnetism. The chronobiological and chronomic interpretation of ambulatory blood pressure monitoring (C-ABPM) records in the light of time-specified reference values derived from healthy peers matched by sex and age identify vascular variability anomalies (VVAs) for an assessment of cardio-, cerebro-, and renovascular disease risk. Even within the conventionally accepted normal range, VVAs have been associated with a statistically significant increase in risk. Long-term C-ABPM records help to "know ourselves," serving for relief of psychological and other strain once transient VVAs are linked to the source of a load, prompting adjustment of one's lifestyle for strain reduction. Persistent circadian VVAs can be treated, sometimes by no more than a change in timing of the daily administration of antihypertensive medication. Circadian VVA assessment is an emergency worldwide, prompted in the United States by 1,000 deaths per day every day from problems related to blood pressure. While some heads of state met under United Nation and World Health Organization sponsorship to declare that noncommunicable diseases are a slow-motion disaster, a resolution has been drafted to propose C-ABPM as an added tool complementing purely physical environmental monitoring to contribute also to the understanding of social and natural as well as personal cataclysms.

Chronobiology of Aging: A Mini-Review

“…S8). In an outcome study, uncomplicated MESOR-hypertension was associated with about 9% morbidity at the 6-year follow-up [19] . Deviation from the norm by 1 or 2 additional features of blood pressure or heart rate variability raised 6-year morbidity from 9 to 29 and 53%, respectively [19] .…”

“…In an outcome study, uncomplicated MESOR-hypertension was associated with about 9% morbidity at the 6-year follow-up [19] . Deviation from the norm by 1 or 2 additional features of blood pressure or heart rate variability raised 6-year morbidity from 9 to 29 and 53%, respectively [19] . Recognizing that different patients present with differently altered circadian profiles of blood pressure (chronodiagnosis), chronotherapy is best adjusted to the chronodiagnosis (chronotheranostics) [43] via truly personalized medicine, since the optimal treatment time differs from one patient to another, as demonstrated in a study by Watanabe et al [48] .…”

“…S4). The increased prominence of infradian components with advancing age reflects an increased day-to-day variability in the circadian characteristics of blood pressure, in part accounted for by increased aboutweekly variation and modulations by long-period cycles present in space weather, such as the about 1.3-year and 11-year cycles characteristic of solar wind speed and solar activity, respectively [19] , observed also in a longitudinal record of daily urinary excretion of 17-ketosteroids [20] .…”

“…Gerontology 2017;63:118-128 DOI: 10.1159/000450945 126 data from presumably healthy people, some monitored around the clock for decades by a few dedicated individuals [19] . It thus becomes possible to derive time-specified reference values and reference values for the MESOR, circadian amplitude, and circadian acrophase, further qualified by gender and age.…”

Bromocriptine-QR therapy for the management of type 2 diabetes mellitus: developmental basis and therapeutic profile summary

“…It is worth noting that the time of day that bromocriptine-QR is administered to restore the normal circadian peak in CNS dopaminergic activity (within 2 h of waking in the morning) to treat cardiometabolic disease coincides with the time of day of increased cardiovascular events and elevated sympathetic tone in metabolic syndrome (i.e. early morning hours of the day near awaking from sleep, nondipper pathophysiology) [189][190][191][192][193][194]. It may be interpreted that morning administration of bromocriptine-QR is attenuating the early morning abnormal elevation in sympathetic tone, insulin resistance, and inflammatory activity, and thus reducing increased morning risk of CV events due to its immediate inhibition of sympathetic tone and inflammation in the periphery.…”