Treatment with olanzapine, fluoxetine and olanzapine/fluoxetine alters citrate synthase activity in rat brain

Abstract

A growing body of evidence has indicated that energy metabolism impairment may be involved in pathophysiology of some neuropsychiatric disorders. In this study, we evaluated the effect of acute and chronic administration of fluoxetine, olanzapine and the combination of fluoxetine/olanzapine on citrate synthase activity in brain of rats. For acute treatment, Wistar rats received one single injection of olanzapine (3 or 6mg/kg) and/or fluoxetine (12.5 or 25mg/kg). For chronic treatment, rats received daily injections of olanzapine (3 or 6mg/kg) and/or fluoxetine (12.5 or 25mg/kg) for 28 days. In the present study we observed that acute administration of olanzapine inhibited citrate synthase activity in cerebellum and prefrontal cortex. The acute administration of olanzapine increased citrate synthase activity in prefrontal cortex, hippocampus and striatum and fluoxetine increased citrate synthase activity in striatum. Olanzapine 3mg/kg and fluoxetine 12.5mg/kg in combination increased citrate synthase activity in prefrontal cortex, hippocampus and striatum. In the chronic treatment we did not observed any effect on citrate synthase activity. Our results showed that olanzapine and fluoxetine increased citrate synthase activity after acute, but not chronic treatment.

Serotonin modulation in neonatal age does not impair cardiovascular physiology in adult female rats: Hemodynamics and oxidative stress analysis

“…treatment improves antioxidant defense and decreases oxidative stress [47,48]. In addition to the observation related to oxidative stress, our study also showed that Fx increased the CS activity in brainstem and tendency in heart; in concordance with our observation, previous studies with Fx or imipramine (also a neurotransmitter reuptake inhibitor) showed that serotonin modulation increases CS activity in amygdala [49], corpus striatum [50], hypothalamus [18], and skeletal muscle [18].…”

Anti‐inflammatory, antiapoptotic, and antioxidant activity of fluoxetine

“…Moreover, acute treatment with fluoxetine alters the activity of the enzyme citrate synthase and both acute and chronic treatments modify the activity of the enzyme creatine kinase (Agostinho et al. , ). These enzymes are involved in cell metabolism and the relationship between fluoxetine and energy metabolism has been clearly demonstrated, which is correlated with neuropsychiatric disorders (Ben‐Shachar and Karry ; Quiroz et al.…”

Pharmacometabolomic mapping of early biochemical changes induced by sertraline and placebo

“…12, 13, 14 Different antidepressants, including SSRIs, following their chronic administration have been found to increase biomarkers for energy metabolism. 15, 16, 17, 18 …”