Treatment with Herbal Mouthwash Mediates Improvement of Symptoms in Xerostomia and Oral Mucositis patients

Abstract

Oral discomfort and pain are frequent side-effects of many popular prescription medications. Over 500 prescription drugs are known to result in the development of adverse oral conditions. In fact, approximately 40% of patients suffer from xerostomia and oral mucositis, as a result of cancer medications. The number of affected individuals is expected to continue to rise, given that the incidence of major cancers is predicted to grow over the next decade. Regrettably, there are currently lacks of treatments available to effectively improve xerostomia and oral mucositis symptoms. Interestingly, the use of several herbal ingredients (such as chamomile, cinnamon, and peppermint oil) has been reported to effectively improve pain and oral dryness. For this reason, we examined the effectiveness of an herbal mouthwash, Nature’s Herbal (a blend of cinnamon oil, chamomile, cranberry, and peppermint extract), to alleviate symptoms of oral pain and dry mouth exhibited by patients diagnosed with oral mucositis and xerostomia. Daily treatment with the mouthwash induced a 53% ± 6% and 33.2% ± 3.8% improvement in the severity of symptom, for the oral mucositis and xerostomia patients groups, respectively. Overall, the herbal mouthwash induced an improvement in 91% of oral mucositis and 83% of xerostomia patients.

Phytochemical Properties and In Vitro Biological Activities of Phenolic Compounds from Flower of Clitoria ternatea L.

“…α-amylase, the inhibition of which is considered a strategy in the treatment of type 2 diabetes, is an enzyme that plays a key role in the digestion of starch [ 34 ]. As a result, α-amylase has also been recognized as a therapeutic target for the modulation of postprandial hyperglycemia.…”

Extraction and purification of total flavonoids from Eupatorium lindleyanum DC. and evaluation of their antioxidant and enzyme inhibitory activities

“…Inhibition of α‐amylase, an enzyme that plays a key role in digestion of starch, is considered as a strategy in the treatment of type II diabetes (Berrout et al., 2018). The α‐amylase inhibitory activity of PTFELDC was plotted in Figure 4b.…”

Antimicrobial Activity and Cytotoxicity of Mouthwash Prepared from Azadirachta indica and Stevia rebaudiana Extract– An In vitro Study

“…Some ingredients that act as digestive aids are also found in mouthwash. Today, we use an industrial mouthwash containing several chemical compounds that are toxic to our oral cavities such as thymol, methyl salicylate, and hydrogen peroxide [5][6][7][8][9]. The majority of industrial mouth rinses use alcohol to destroy bacteria, and anyone who has used an alcohol-based mouthwash knows how irritating it could be.…”