Treatment Trends in Dry Eye Disease and Factors Associated with Ophthalmic Follow-up Discontinuation in Japan

Uchino, Makoto; Yokoi, Norihiko; Kawashima, Motoko; Yamanishi, Ryutaro; Uchino, Yuichi; Ohta, Michio

doi:10.3390/jcm8081120

Cited by 8 publications

(7 citation statements)

References 14 publications

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“…This issue appears to be even more important considering that tear substitutes are an over-the-counter preparation and a plethora of different types are available on the market. A recent study showed that more than two-thirds of the patients with persistent DED reported having discontinued their treatment, and that only one tenth of them was using the same type of tear substitute prescribed by the physician during the visit [43].…”

Section: False Myth #7: "Dry Eye Disease Does Not Influence Surgical Outcomes"mentioning

confidence: 99%

“…Medical Fact #9: "Tear Substitutes Should Be Prescribed and Used with Regular Dosing" a plethora of different types are available on the market. A recent study showed that more than twothirds of the patients with persistent DED reported having discontinued their treatment, and that only one tenth of them was using the same type of tear substitute prescribed by the physician during the visit [43]. An old conception of DED therapy was that the addition of a tear volume to the dry ocular surface alone should be able to solve the disease.…”

Section: False Myth #7: "Dry Eye Disease Does Not Influence Surgical Outcomes"mentioning

confidence: 99%

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False Myths versus Medical Facts: Ten Common Misconceptions Related to Dry Eye Disease

Giannaccare¹,

Scorcia²

2020

Biomedicines

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Since the first definition of dry eye, rapid progress has been made in this field over the past decades that has guided profound changes in the definition, classification, diagnosis and management of the disease. Although dry eye is one of the most frequently encountered ocular conditions, various “old” misconceptions persist, in particular among comprehensive ophthalmologists not specialized in ocular surface diseases. These misconceptions hamper the correct diagnosis and the proper management of dry eye in the routine clinical practice. In the present review, we described the 10 most common misconceptions related to dry eye and provided an evidence-based guide for reconsidering them using the format “false myth versus medical fact”. These misconceptions concern the dry eye definition and classification (#1, #2, #3), disease physiopathology (#4), diagnosis (#5), symptoms (#6, #7) and treatment (#8, #9, #10). Nowadays, dry eye is still an under-recognized and evolving disease that poses significant clinical challenges to ophthalmologists. The two major reasons behind these challenges include the heterogeneity of the conditions that fall under the umbrella term of dry eye and the common discrepancy between signs and symptoms.

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Section: False Myth #7: "Dry Eye Disease Does Not Influence Surgical Outcomes"mentioning

confidence: 99%

Section: False Myth #7: "Dry Eye Disease Does Not Influence Surgical Outcomes"mentioning

confidence: 99%

False Myths versus Medical Facts: Ten Common Misconceptions Related to Dry Eye Disease

Giannaccare¹,

Scorcia²

2020

Biomedicines

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“…Although DED is not curable, timely and efficient treatment can relieve the symptoms. However, one study found that patients tended to discontinue follow-ups as DED prolonged after diagnosis ( 35 ). Thus, timely and comprehensive education on patient is essential to prevent their discouragement on following treatment.…”

Section: Discussionmentioning

confidence: 99%

Estimated Annual Economic Burden of Dry Eye Disease Based on a Multi-Center Analysis in China: A Retrospective Study

Yang

Niu³

et al. 2021

Front. Med.

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Purpose: To conduct a multi-center analysis and assess the economic burden due to dry eye disease (DED) in China.Design: A retrospective and cross-sectional study.Methods: Patients (n = 598) with diagnosed DED were recruited from 3 eye centers (in central, southeast, and northeast China) from 1 January 2018 to 31 December 2018. Data were collected regarding the examination, pharmacological therapy, and non-pharmacological therapy fees. Sub-group analyses were stratified by eye center, DED severity, types of DED, number of visits to physicians, and residential area. A logistic regression analysis was conducted to investigate the variables influencing total costs.Results: The per capita costs devoted to DED at the 3 centers were 422.6, 391.3, and 265.4 USD, respectively. The costs of non-pharmacological therapy accounted the largest part in three centers (75.6, 76.4, 76.5%, respectively). Patients with severe DED sustained the largest economic burden. Patients with mixed type of DED spent the most comparing to patients with either evaporative or aqueous-deficient types of DED. Patients spent more during the first visit compared with subsequent visits. Patients living in urban areas spent significantly more than did those living in rural areas (P = 0.001). The logistics regression analysis showed that total costs were significantly influenced by DED severity, number of visits to physicians, and area of residence (beta = 2.83, 0.83, 1.48; P < 0.0001).Conclusions: DED is a chronic ocular disease that timely non-cost counseling, early diagnosis, and efficacious treatment can reduce its economic burden on patients and the society.

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“…EDE or ADDE with consideration of the presence of symptoms and clinical signs [331,339]. A recent concept in CLIDE management suggested by the Japanese Dry Eye Society in their report on Tear Film Oriented Therapy [347,348] focused on targeting either the tear film or the contact lens or both [296].…”

Section: Managementmentioning

confidence: 99%

BCLA CLEAR - Contact lens complications

Stapleton

Bakkar

Carnt

et al. 2021

Contact Lens and Anterior Eye

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Contact lens-related complications are common, affecting around one third of wearers, although most are mild and easily managed. Contact lenses have well-defined anatomical and physiological effects on the ocular surface and can result in other consequences due to the presence of a biologically active material. A contact lens interacts with the tear film, ocular surface, skin, endogenous and environmental microorganisms, components of care solutions and other antigens which may result in disease specific to contact lens wear, such as metabolic or hypersensitivity disorders. Contact lens wear may also modify the epidemiology or pathophysiology of recognised conditions, such as papillary conjunctivitis or microbial keratitis. Wearers may also present with intercurrent disease, meaning concomitant or pre-existing conditions unrelated to contact lens wear, such as allergic eye disease or blepharitis, which may complicate the diagnosis and management of contact lens-related disease.Complications can be grouped into corneal infection (microbial keratitis), corneal inflammation (sterile keratitis), metabolic conditions (epithelial: microcysts, vacuoles, bullae, tight lens syndrome, epithelial oedema; stromal: superficial and deep neovascularisation, stromal oedema [striae/folds], endothelial: blebs, polymegethism/ pleomorphism), mechanical (corneal abrasion, corneal erosion, lens binding, warpage/refractive error changes; superior epithelial arcuate lesion, mucin balls, conjunctival epithelial flaps, ptosis, discomfort), toxic and allergic disorders (papillary conjunctivitis, solution-induced corneal staining, incomplete neutralisation of peroxide, Limbal Stem Cell Deficiency), tear resurfacing disorders/dry eye (contact lens-induced dry eye, Meibomian gland dysfunction, lid wiper epitheliopathy, lid parallel conjunctival folds, inferior closure stain, 3 and 9 o'clock stain, dellen, dimple veil) or contact lens discomfort. This report summarises the best available evidence for the classification, epidemiology, pathophysiology, management and prevention of contact lensrelated complications in addition to presenting strategies for optimising contact lens wear.

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Treatment Trends in Dry Eye Disease and Factors Associated with Ophthalmic Follow-up Discontinuation in Japan

Cited by 8 publications

References 14 publications

False Myths versus Medical Facts: Ten Common Misconceptions Related to Dry Eye Disease

False Myths versus Medical Facts: Ten Common Misconceptions Related to Dry Eye Disease

Estimated Annual Economic Burden of Dry Eye Disease Based on a Multi-Center Analysis in China: A Retrospective Study

BCLA CLEAR - Contact lens complications

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