Treatment strategies for persistent methicillin‐resistantStaphylococcus aureusbacteraemia

Abstract

Given the heterogeneity of the data, a preferred regimen has not emerged. Prescribers must take into consideration recent exposure, source control, and available synergy and clinical data. Further comparative trials are needed to establish a preferred regimen and the creation of a universal treatment algorithm.

Incidence and antimicrobial susceptibility of Staphylococcus aureus isolated from ready-to-eat foods of animal origin from tourist destinations of North-western Himalayas, Himachal Pradesh, India

“…It is an important observation since vancomycin remains the cornerstone for management of MRSA infection (Lewis et al 2018). Its efficacy is now being questioned with the emergence of strains of S. aureus that display intermediate resistance or complete vancomycin resistance and occasionally treatment failures (Holmes and Howden 2014;Lewis et al 2018). High levels of resistance were observed to clindamycin (68.8%, 11/16) and erythromycin (75.0%, 12/16).…”

“…Clindamycin is a bacteriostatic antimicrobial and inhibits bacterial toxin production. Clindamycin can be indicated for management of S. aureus infections including those caused by MRSA (Lewis et al 2018). It is important to note that high levels of erythromycin resistance in S. aureus/MRSA isolates induce clindamycin resistance.…”

“…These observations demand a prudent use of antibiotics for treating patients suffering from staphylococcal food illness. Combination therapy involving two or more antibiotic with different mechanisms of action will provide effective therapy to treat MRSA infection and will also delay the development of antimicrobial resistant strains (Lewis et al 2018). Due to limited resources, we could not perform agar dilution or E test assays on S. aureus recovered in this study for determining antimicrobial susceptibility.…”

“…Vancomycin remains an acceptable treatment option for MRSA caused infections (Holmes and Howden 2014). Vancomycin treatment failures and rising or high vancomycin minimum inhibitory concentrations (MICs) had been associated with higher mortality rates in MRSA infected patients (Holmes and Howden 2014;Lewis et al 2018). In the present study, we determined the prevalence of S. aureus and strains producing A, B, D and E enterotoxins, most commonly associated with food poisoning outbreaks, in ready-to-eat (RTE) milk and meat products from various tourist places of North-western Himalayas located in Himachal Pradesh, India (Mehrotra et al 2000).…”

Exploring the Role of Piperacillin and Tazobactam in Combination with Vancomycin against Methicillin-Resistant <b><i>Staphylococcus aureus</i></b>

“…Additionally, a recent article by Zheng et al [4] found that the combinations of TZP with VAN and cefazolin with VAN prevented VAN intermediate resistance development in vitro [4]. Clinical investigations of adjuvant β-lactam therapy in combination with VAN demonstrated that combination therapy accelerates the time to bacterial clearance [5].…”