Treatment results of oral verrucous carcinoma and its biological behavior

Ogawa, Atsushi; Fukuta, Yoshiyasu; Nakajima, T.; Kanno, Senji; Obara, Akiho; Nakamura, Keiko; Mizuki, Harumi; Takeda, Yasunori; Satoh, Masanobu

doi:10.1016/j.oraloncology.2004.01.008

Cited by 33 publications

(42 citation statements)

References 9 publications

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“…2,4 The present DNA Index data obtained by hr DNA-FCM complement our recent data on the expression of basement membrane proteins in OVCs as obtained by immunohistochemistry. 2 The staining pattern of basement membrane (laminin-5 and collagen IV) of OVC was more often continuous than in the preneoplastic lesion, and was always well expressed, which may explain the low malignant potential and poor ability to invade surrounding tissues.…”

Section: Discussionsupporting

confidence: 84%

“…Several authors have previously addressed clinical features and treatment outcomes of OVC with case series larger than the present one. 4,[14][15][16][17] This study did not aim to address these issues but provided and discussed new data on CIN and DNA aneuploidy in OVC. This issue is particularly interesting when considering the characteristic biological behavior of OVC, which distinctly differs from that of conventional carcinomas.…”

Section: Discussionmentioning

confidence: 99%

“…This issue is particularly interesting when considering the characteristic biological behavior of OVC, which distinctly differs from that of conventional carcinomas. 3,4 Generally, OVC is locally aggressive and has a low propensity for regional as well as distant metastases. 17,18 To our knowledge, DNA ploidy data have been previously reported in just 4 OVC lesions.…”

Section: Discussionmentioning

confidence: 99%

“…Oral verrucous carcinoma (OVC), first described in 1948 by Ackermann, 1 is a rare variant (2%-10%) [2][3][4] of oral squamous cell carcinoma (OSCC). Although many experts consider this tumor a distinct neoplastic entity unto itself, the current World Health Organization classification describes OVC as a slowly growing variant of OSCC with pushing margins.…”

mentioning

confidence: 99%

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Distinctive chromosomal instability patterns in oral verrucous and squamous cell carcinomas detected by high‐resolution DNA flow cytometry

Pentenero¹,

Donadini²,

Nallo³

et al. 2011

Cancer

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BACKGROUND: Oral verrucous carcinomas (OVCs) are characterized by better prognosis than oral squamous cell carcinomas (OSCCs). Because chromosomal instability (CIN) in solid tumors is indicative of prognosis, this study investigated whether OVCs and OSCCs were characterized by differences in CIN biomarkers. METHODS: Fresh or frozen multiple tissue samples were submitted to high-resolution DNA flow cytometry (hr DNA-FCM). RESULTS: DNA aneuploid sublines were detected in 6 of 9 OVCs (66.7%) and in 20 of 25 OSCCs (80.0%). Multiple DNA aneuploid sublines were observed, respectively, in 2 of 6 (33.3%) DNA aneuploid OVCs and in 14 of 20 (70%) DNA aneuploid OSCCs (P ¼ .163). OVCs were mainly characterized by DNA Index (DI) values in the near-diploid region (DI=1 and DI < 1.4), whereas aneuploid OSCCs carried most frequently multiple aneuploid sublines with high DI values (DI ! 1.4). DNA near-diploid and high aneuploid sublines were, respectively, 87.5% and 12.5% for the OVCs versus 30% and 70% for the OSCCs (P ¼ .004). CONCLUSIONS: Present data suggest that OVCs are characterized by a lower degree of CIN and tumor heterogeneity than OSCCs, such that they appear as ''frozen'' in an early stage of DNA near-diploid aneuploidy, as previously observed for oral preneoplastic lesions. These DI characteristics, which can easily be obtained by hr DNA-FCM, appear to reflect the well-known differences in aggressiveness and prognosis of OVCs and OSCCs. Cancer 2011;117:5052-

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Section: Discussionsupporting

confidence: 84%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Distinctive chromosomal instability patterns in oral verrucous and squamous cell carcinomas detected by high‐resolution DNA flow cytometry

Pentenero¹,

Donadini²,

Nallo³

et al. 2011

Cancer

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“…CD44v9 was detected in VC more frequently than conventional SCC which possibly explains the low incidence of metastasis to lymphatics [22]. The immunohistochemical expression of p16 was low in dysplasia and squamous cell carcinoma, whereas it was high in VC.…”

Section: Demographic Data Of the Analysed Samplementioning

confidence: 90%

Reliability of Incision Biopsy for Diagnosis of Oral Verrucous Carcinoma: A Multivariate Clinicopathological Study

Gokavarapu

Rao

Patnaik

et al. 2014

J. Maxillofac. Oral Surg.

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Introduction Studies have reported 20 % of conventional squamous cell carcinoma in patients with verrucous carcinoma (VC), later these cancers were termed as hybrid VC. It is important to distinguish both while planning treatment since hybrid VC requires addressing regional lymphatics in addition to respective surgery. Information on odds of missing the foci of invasion on routine incision biopsy might be useful in this regard. Patients and MethodsRecords of all the patients surgically treated for oral cancer from Jan 2010 to Oct 2013 in a Tertiary Cancer Centre was analyzed. Patients diagnosed with primary VC or Verrucous Hyperplasia on incision biopsy were included in the study. Proportion of patients undiagnosed for invasive component on incision biopsy was calculated, multivariate analysis of the sample was performed to find associated cofounders. Results Fifty-five patients who reported with the diagnosis of VC (n = 53) or Verrucous Hyperplasia (n = 2) on incision biopsy were included in the study. Twenty-seven were diagnosed as VC and 28 as hybrid VC after excision. This corresponded to 51 % (n = 28) of cases missing invasive component on incision biopsy. VC was significantly more commonly seen in lip and in buccal mucosa, hybrid VC was more commonly seen in tongue and gingiva and this association was statistically significant (p = 0.031) in our study. Conclusion Incision biopsy is extremely unreliable to diagnose and differentiate oral Hybrid VC from VC or Verrucous Hyperplasia. Caution is required while planning treatment of these patients regarding possibility of presence of conventional squamous cell carcinoma within these tumors.

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