Distinctive chromosomal instability patterns in oral verrucous and squamous cell carcinomas detected by high‐resolution DNA flow cytometry

Pentenero, Monica; Donadini, Alessandra; Nallo, Emanuela Di; Maffei, Massimo; Marino, Roberto Luiz; Familiari, Ubaldo; Broccoletti, Roberto; Castagnola, Patrizio; Gandolfo, S; Giaretti, Walter

doi:10.1002/cncr.26126

Cited by 14 publications

(9 citation statements)

References 20 publications

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“…High DNA aneuploid sublines were predominant (67%) for the OSCCs, which were in addition characterized by the presence of multiple DNA aneuploid sublines in 52% of the DNA aneuploid cases. In contrast, OVCs were characterized by DNA near-diploid aneuploid sublines in 67% of the cases in agreement with previously published data (Pentenero et al, 2011). Overall, the present data support a previous model of aneuploidy genesis and evolution (Giaretti, 1994).…”

Section: Discussionsupporting

confidence: 93%

Model of Chromosomal Instability in Oral Carcinogenesis and Progression

Giaretti¹

2012

Oral Cancer

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Section: Discussionsupporting

confidence: 93%

Model of Chromosomal Instability in Oral Carcinogenesis and Progression

Giaretti¹

2012

Oral Cancer

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“…Another interesting aspect is the development of VC in PVL. VC is a rare histological type, involving only 2–10% of oral carcinomas, which, conversely, are more often observed in patients with PVL …”

Section: Discussionmentioning

confidence: 99%

Oral proliferative verrucous leucoplakia: are there particular features for such an ambiguous entity? A systematic review

et al. 2014

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Proliferative verrucous leucoplakia (PVL) is a distinct, particularly aggressive form of oral leucoplakia. Given the low prevalence of PVL, data are sparse and are mostly from case reports, case series and only a few case-control studies, meaning that the literature is able to provide only weak evidence. The present systematic literature review aims to collate the available evidence on the following issues: patient demographics, aetiology, lesion location(s), malignant potential, location and histopathological features of transformed lesions, disease-specific survival rates and treatment response. Electronic databases were searched for studies in the English language reporting original data from at least 10 patients with PVL on the target issues of the present review. The retrieved data were merged and a descriptive analysis performed. The 20 studies selected indicated that PVL does not seem to be correlated with the major risk factors for oral carcinoma (tobacco, alcohol and/or areca nut/betel leaf chewing). The disorder affects mainly adult/elderly women and has a very high malignant transformation rate, particular site distribution and particular location and histopathological features of transformed lesions. The present results may be limited by some articles being unintentionally excluded as they were not found during the electronic search, a lack of worldwide accepted diagnostic criteria for PVL, and overlapping data from multiple studies performed in a limited number of centres. Despite these potential drawbacks, the present results demonstrate that PVL does have particular features.

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“…OVC has some pathological similarities to OSCC, especially for well-differentiated OSCC and OVC. Aiming at assessing and validating biomarkers for better understanding of the genesis and molecular mechanisms of OVC and OSCC, Pentenero et al (84) found OVC and OSCC could be differently characterized using chromosomal instability biomarkers. The difference in aggressiveness and prognosis of OVC and OSCC was reflected by DNA index characteristics.…”

Section: Ovc and Oral Squamous Papilloma (Osp)mentioning

confidence: 99%

Oral verrucous carcinoma: From multifactorial etiology to diverse treatment regimens (Review)

Peng

Wang

Quan

et al. 2016

International Journal of Oncology

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Abstract. Oral verrucous carcinoma (OVC) is a verrucous variant of oral squamous cell carcinoma (OSCC), which accounts for 2-12% of all oral carcinomas with a 5-year survival rate of only approximately 50%. Enormous effort has been dedicated to this cancer, and the past decades have witnessed significant advances in relevant diagnostic and therapeutic approaches. Currently, there exist three challenges from primary sub-fields of research and clinical practice of the cancer, namely multifactorial etiology, complex molecular mechanism, and deficient treatment. This study reviews the existing literature on the cancer, encompassing its etiology, clinical manifestations and pathology, molecular mechanism, diagnosis and differential diagnosis, and treatment. For improved treatment of OVC, multifactorial etiology analysis, incorporation of effective biomarkers for mechanism illustration, and integration of multidisciplinary modalities are expounded, in an attempt to resolve the challenges and to provide a useful guide for future research in the field.

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Distinctive chromosomal instability patterns in oral verrucous and squamous cell carcinomas detected by high‐resolution DNA flow cytometry

Cited by 14 publications

References 20 publications

Model of Chromosomal Instability in Oral Carcinogenesis and Progression

Model of Chromosomal Instability in Oral Carcinogenesis and Progression

Oral proliferative verrucous leucoplakia: are there particular features for such an ambiguous entity? A systematic review

Oral verrucous carcinoma: From multifactorial etiology to diverse treatment regimens (Review)

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