Treatment policy of surgery in small cell carcinoma of the lung: retrospective analysis of a series of 874 consecutive patients.

Østerlind, Kell; Hansen, Mogens; Hansen, Heine H.; Dombernowsky, P; Rørth, Mikael

doi:10.1136/thx.40.4.272

Cited by 30 publications

(11 citation statements)

References 12 publications

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“…The introduction of combination chemotherapy in the management of small cell lung cancer (SCLC) led to an increase in median survival and suggests that a significant proportion of patients could be cured [1], Long-term survival, however, is still rare, being only 5-10% at 3 years and 2-3% at 5 years [2][3][4], Although surgery and/or radiotherapy have been used in com bination with chemotherapy to reduce local relapse, thereby improving survival, the benefit of these treat ment modalities on survival is controversial [5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Long-Term Survivors in Resected and Nonresected Small Cell Lung Cancer

Hara

Ichinose²,

Kuda³

et al. 1991

Oncology

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Long-term survival (≥3 years) was evaluated in 164 patients with small cell lung cancer (SCLC). Thirty-seven patients underwent surgical resection, and 127 did not. All but one resected patient received combination chemotherapy. Of the 20 (12%) long-term survivors, 13 (35%) were resected, and 7 (6%) were not. Eleven of these resected patients had pathologically confirmed stage I disease. All of the 7 nonresected patients achieved complete remission by treatment, 6 of these having presented with limited disease. In addition, all patients received thoracic irradiation combined with chemotherapy. Two of the 20 patients who survived beyond 3 years developed a second malignancy 11.3 and 12 years, respectively, after initial treatment for SCLC. In conclusion, surgical resection for stage I, and probably stage II SCLC followed by chemotherapy may be an appropriate therapeutic approach. For advanced limited disease, thoracic irradiation, in addition to chemotherapy, seems to improve long-term survival.

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Section: Introductionmentioning

confidence: 99%

Long-Term Survivors in Resected and Nonresected Small Cell Lung Cancer

Hara

Ichinose²,

Kuda³

et al. 1991

Oncology

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“…There were 11 patients with a nodule 3 cm or less in diameter whereas in four others it was larger than 3 cni ( Table 3). As is often the case in non-small cell lung cancer presenting as SPN, there were four instances of the SPN being present in retrospect for several months before diagnosis (7,12,18, 22 months, respectively).…”

Section: Resultsmentioning

confidence: 73%

Small cell lung cancer presenting as a solitary pulmonary nodule

Quoix

Fraser

Wolkove

et al. 1990

Cancer

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Small cell lung cancer (SCLC) rarely presents radiographically as a solitary pulmonary nodule (SPN). Twenty‐five patients with this feature were identified among 408 individuals with SCLC at McGill University (Montreal, Quebec) from 1979 through 1984. Of these, 15 (60%) were confirmed on pathologic review as SCLC (ten intermediate cell, four oat cell, one indeterminate). Pathologic review of a control group comprising 24 other limited‐disease patients who were long‐term survivors (> 20 months) confirmed 20 (84%) as SCLC (eight intermediate cell, 12 oat cell). Ten of the 15 patients with SPN were resected whereas five had chemotherapy and/or radiotherapy as primary treatment. Postoperative chemotherapy was administered to most of the resected patients. The median survival of the 15 patients with SPN was 24 months, a significantly longer survival than the other patients with SCLC. This improved prognosis in patients with SPN may be due to smaller initial tumor burden or to a fundamental biologic difference between SPN and other forms of SCLC.

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Section: Surgery and Perioperative Chemotherapymentioning

confidence: 96%

“…Reflective of the increased knowledge of the biology of lung carcinoma is a significant observation in a number of studies (Table 11). There is a discrepancy in the his- Maassen and Greschuehna [35] Shepherd et al [33] Osterlind et al [36] Rahbek-Sorensen et al [37] Ohta et al [38] Hayata et al [ Einhorn and Williams [41] Valdivieso et al [42] Williams et al [43] tology of prechemotherapy nonsurgical biopsy and the postchemotherapy surgical biopsy. This has been referred to as "histologic conversion."…”

Section: Surgery and Perioperative Chemotherapymentioning

confidence: 99%

Evolving role of surgical treatment in limited‐disease small cell lung carcinoma

Sridhar

Hussein

Thurer

1989

Journal of Surgical Oncology

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The diagnostic role of surgical procedures in small cell lung carcinoma (SCLC) is well established. The therapeutic role of surgery has changed over the years. At present, curative resection is the treatment of choice in peripheral T1-2 N0M0 SCLC, and adjuvant chemotherapy may be beneficial. Surgery is also indicated in SCLC patients diagnosed by a limited pathologic sample in whom the clinical course suggests nonsmall cell lung carcinoma (NSCLC). The resection may reveal either a mixed tumor or an alternate diagnosis and may be potentially curative. Surgery, at the time of maximal response to chemotherapy in T3N0M0 SCLC, may be curative and reveal the presence of NSCLC elements. The best survival is in patients found to be tumor-free at surgery, and the worst survival is in N2 patients.

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Treatment policy of surgery in small cell carcinoma of the lung: retrospective analysis of a series of 874 consecutive patients.

Abstract: ABsTRAcr A therapeutic policy of surgery in the treatment of small cell carcinoma of the lung was evaluated in a retrospective series of 874

Cited by 30 publications

References 12 publications

Long-Term Survivors in Resected and Nonresected Small Cell Lung Cancer

Long-Term Survivors in Resected and Nonresected Small Cell Lung Cancer

Small cell lung cancer presenting as a solitary pulmonary nodule

Evolving role of surgical treatment in limited‐disease small cell lung carcinoma

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