Treatment outcomes of human bartonellosis: a systematic review and meta-analysis

Abstract

Current clinical practice for the treatment of bartonellosis relies mostly on expert opinion and antimicrobial susceptibility data. Randomized controlled trials are needed in the field to compare different treatment options.

Halk Sağlığı Açısından Pet ve Başıboş Kedilerde Bartonella henselae Prevelansı: Tek Tıp - Tek Sağlık Konseptinde Örnek Bir Çalışma

“…In immune-competent patients, while Bartonella henselae leads to the acute infection known as CSD, it may cause widespread clinical diseases, such as bacillary angiomatosis, encephalopathy, peliosis hepatitis, splenitis, osteomyelitis and bacteriaemia in immune-compromised patients [2][3][4]11,30,31] . Treatment of Bartonellosis is carried out in the light of personnel experience, expert opinion and microbiological sensitivity data depending on the infection agent, clinical disease duration and immunological status of the patient [4,30,32] . Efforts to standardize antibiotic dose and duration treatment regimens, based upon both in vitro antibiotic susceptibility testing and patient outcome assessments are critically needed to effectively manage patients with neurobartonellosis and to elucidate the mechanisms by which chronic interplay between the host and bacteria ultimately leads to neurological manifestations [31] .…”

“…Efforts to standardize antibiotic dose and duration treatment regimens, based upon both in vitro antibiotic susceptibility testing and patient outcome assessments are critically needed to effectively manage patients with neurobartonellosis and to elucidate the mechanisms by which chronic interplay between the host and bacteria ultimately leads to neurological manifestations [31] . In addition, antibiotics used in these treatments have been reported to be ineffective in the rate of recovery or success at any significant level [32] . In China, Bartonella sp.…”

Bartonella Neuroretinitis: A Case Report with New Insights from Fundus Autofluorescence Imaging

“…Although management with systemic steroid and antibiotics has been described [12], such treatment is not universally advocated [13]. The decision to treat our patient with systemic oral antibiotics was influenced by his initial severe vision loss in the right eye.…”

Infección por Bartonella henselae con compromiso de sistema nervioso central, asociado a un papiloma del plexo coroídeo

“…Las bacterias del género Bartonella son susceptibles in vitro a varios antimicrobianos incluidos penicilinas, cefalosporinas, aminoglucósidos, cloranfenicol, tetraciclinas, macrólidos, rifampicina, fluoroquinolonas y cotrimoxazol. Existe discordancia entre la sensibilidad in vitro y la utilidad clínica de los diferentes antimicrobianos, posiblemente explicada por la ubicación intracelular de la bacteria 1,3,7,23,30 . Frente a las infecciones graves se recomienda utilizar dos antimicrobianos con diferentes mecanismos de acción para lograr una mejor erradicación 7 , fue por esto que nuestra paciente se trató con ceftriaxona y rifampicina 31 .…”