Treatment Outcomes of Chemoradiotherapy for Anal Canal Squamous Cell Carcinoma in Japan

Abstract

Chemoradiation therapy (CRT) is becoming the standard treatment for anal canal squamous cell carcinoma (AC-SCC). In this study, we examined the treatment results of 7 cases of ACSCC treated at our hospital. TNM classification was 1 case, 1 case, 5 cases and 0 case of Stage Ⅰ, Ⅱ, Ⅲ and Ⅳ, respectively. CRT was performed in all cases. Two courses of chemotherapy with 5-FU and mitomycin C (cisplatin for one patient) were performed. Radiation therapy was performed in the pelvis and both inguinal lymph node areas. As a result, CR was obtained in all cases and all cases survived without recurrence. As Grade 3 or higher adverse events, diarrhea, hematologic adverse events and radiation dermatitis occurred.Grade 2 radiation rectalitis and radiation cystitis were observed as late adverse effects. We also searched case reports of ACSCC treated with CRT in Japan and obtained relatively good outcomes. CRT is considered to be a curative treatment method in Japan.