Treatment outcome of localizedHelicobacter pylori-negative low-grade gastric MALT lymphoma

Abstract

Our new scoring system is simple, efficient, and can be considered to be applicable in clinical practice and research.

Helicobacter pylori-negative gastric mucosa-associated lymphoid tissue lymphomas: A review

“…This was the highest reported response rate among H. pylori-negative gastric MALT lymphomas. The response rate decreased to 46% in their later study [52] , but this was still relatively high compared with other reports [3,[46][47][48][49][50] . Contrary to these reports, earlier studies reported that H. pylorinegative gastric MALT lymphomas did not respond to antibiotic therapy [14,30,45] .…”

“…The first-line treatment for H. pylori-negative gastric MALT lymphomas is also antibiotic therapy [36] . Even in the absence of H. pylori infection, several studies have reported that certain proportions of patients responded to this antibiotic therapy [3,4,14,30,[45][46][47][48][49][50][51][52] (Table 2). …”

“…Steinbach et al [45] (1999) 0/6 (0) Ruskoné-Fourmestraux et al [30] (2001) 0/10 (0) Ye et al [14] (2003) 0/5 (0) Nakamura et al [3] (2006) 2/7 (29) Raderer et al [4] (2006) 5/6 (83) Akamatsu et al [46] (2006) 1/9 (11) Terai et al [47] (2008) 1/4 (25) Park et al [48] (2010) 3/4 (75) Asano et al [49] (2012) 5/17 (29) Choi et al [50] (2013) 2/5 (40) Raderer et al [52] (2015) 5/13 (46) but there are several possible speculations. One speculation, as mentioned above, is that these patients were infected with bacteria other than H. pylori, and the antibiotic eradication therapy for H. pylori was able to eradicate this non-H. pylori bacteria [24] .…”

EGILS consensus report. Gastric extranodal marginal zone B-cell lymphoma of MALT

“…H pylori -negative lymphomas,54 55 82 t(11;18)-positive lymphomas30 95 and those with lymph node involvement will hardly respond to antibiotics 55. Patients with gastric MALT lymphoma refractory to H pylori eradication and persistent endoscopic lesions as well as those with disseminated or bulky disease will require further local or systemic treatment.…”

Gastric lymphoma

“…Recent studies have demonstrated that anti-H. Pylori therapy can achieve the remission of indolent lymphoma, H. pylori negative MALT lymphoma and DLBCL. 4,20 …”