EGILS consensus report. Gastric extranodal marginal zone B-cell lymphoma of MALT

Ruskoné-Fourmestraux, A; Fischbach, Wolfgang; Aleman, B.M.P.; Boot, H.; Du, Ming‐Qing; Mégraud, Françis; Montalbán, Carlos; Raderer, Markus; Savio, Antonella; Wotherspoon, Andrew

doi:10.1136/gut.2010.224949

Cited by 320 publications

(412 citation statements)

References 138 publications

(95 reference statements)

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“…A recent systematic review evaluating 32 studies involving 1,408 patients with low-grade MALT lymphoma showed the presence of H pylori infection in 88.2% of cases and complete remission of the tumor just by eradicating the bacteria in over 75% of cases (214) . A recent consensus meeting acknowledges H pylori eradication to be a first line treatment for gastric MALT lymphoma (177) .…”

Section: Statement 11mentioning

confidence: 99%

3rd BRAZILIAN CONSENSUS ON Helicobacter pylori

Coelho

Maguinilk

Zaterka³

et al. 2013

Arq. Gastroenterol.

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Significant progress has been obtained since the Second Brazilian Consensus Conference on Helicobacter pylori Infection held in 2004, in São Paulo, SP, Brazil, and justify a third meeting to establish updated guidelines on the current management of H. pylori infection. The Third Brazilian Consensus Conference on H pylori Infection was organized by the Brazilian Nucleus for the Study of Helicobacter, a Department of the Brazilian Federation of Gastroenterology and took place on April 12-15, 2011, in Bento Gonçalves, RS, Brazil. Thirty-one delegates coming from the five Brazilian regions and one international guest, including gastroenterologists, pathologists, epidemiologists, and pediatricians undertook the meeting. The participants were allocated in one of the five main topics of the meeting: H pylori, functional dyspepsia and diagnosis; H pylori and gastric cancer; H pylori and other associated disorders; H pylori treatment and retreatment; and, epidemiology of H pylori infection in Brazil. The results of each subgroup were submitted to a final consensus voting to all participants. Relevant data were presented, and the quality of evidence, strength of recommendation, and level of consensus were graded. Seventy per cent and more votes were considered as acceptance for the final statement. This article presents the main recommendations and conclusions to guide Brazilian doctors involved in the management of H pylori infection.

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Section: Statement 11mentioning

confidence: 99%

3rd BRAZILIAN CONSENSUS ON Helicobacter pylori

Coelho

Maguinilk

Zaterka³

et al. 2013

Arq. Gastroenterol.

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“…Biopsy specimens after H. pylori eradication were also evaluated by pathologists in each the hospital, while relapsed cases and suspicious cases were reviewed by the central pathologist (T.Y.). Histopathological evaluation after treatment was carried out using the Groupe d'Etude des Lymphomes de l'Adulte (GELA) histological grading system, with classification as either complete histological response (ChR), probable minimal residual disease (pMRD), responding residual disease (rRD) or no change (NC)8, 16 or Wotherspoon's histological score (0‐5) 3. Complete remission (CR) of lymphoma was defined as ChR or pMRD in the GELA system, or grades 0 or 1 in Wotherspoon's score, with non‐CR defined as any other category.…”

Section: Methodsmentioning

confidence: 99%

“…Approximately 60%‐80% of H. pylori ‐positive gastric MALT lymphomas achieve complete histological response after H. pylori eradication 3, 4, 56, 7, 8, 9, 10, 11…”

Section: Introductionmentioning

confidence: 99%

Anti‐Helicobacter pylori therapy in localized gastric mucosa‐associated lymphoid tissue lymphoma: A prospective, nationwide, multicenter study in Japan

et al. 2018

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Background Helicobacter pylori eradication therapy was approved in Japan for the first‐line, standard treatment of H. pylori‐positive gastric mucosa‐associated lymphoid tissue (MALT) lymphoma. Although several retrospective studies or small‐scale single‐center studies have been reported, a prospective, large‐scale, nationwide, multicenter study has not been reported from Japan.Materials and MethodsWe conducted a prospective, nationwide, multicenter study to evaluate the clinical efficacy of rabeprazole‐based triple H. pylori eradication therapy for patients with localized gastric MALT lymphoma in practice‐based clinical trial. A total of 108 H. pylori‐positive patients with stage I/II 1 gastric MALT lymphoma underwent H. pylori eradication therapy. The primary endpoints were complete remission (CR) rate and the rate of transfer to secondary treatment. The secondary endpoints were CR maintenance duration and overall survival (OS).Results CR of lymphoma was achieved in 84 of 97 patients (86.6%), during the period 2.0‐44.7 months (median, 5.3 months) after starting H. pylori eradication treatment. CR was maintained in 77 of 81 patients (95.1%) for 0.4‐53.2 months (median, 33.1 months). Secondary treatments (radiotherapy, rituximab, or gastrectomy) for gastric MALT lymphoma were needed in 10 of the 97 patients (10.31%). During follow‐up, OS rate was 96.9% (94/97) and the causes of 3 deaths were not related to lymphoma.ConclusionsRabeprazole‐based H. pylori eradication therapy demonstrated a high CR rate, long CR maintenance, and a good OS for patients with localized gastric MALT lymphoma in this prospective, practice‐based, multicenter study.

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“…36 MALT lymphomas are highly sensitive to radiation, which may be curative in localised stage I E and II1 E disease. Different types of chemotherapy with or without immunotherapy have been suggested but efficacy and comparison data are limited and no standard chemotherapy has been defined so far.…”

Section: Extranodal Marginal Zone Lymphoma Of Mucosa-associated Lymphmentioning

confidence: 99%

Extranodal and splenic small B-cell lymphoma

Wotherspoon

2013

Modern Pathology

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EGILS consensus report. Gastric extranodal marginal zone B-cell lymphoma of MALT

Cited by 320 publications

References 138 publications

3rd BRAZILIAN CONSENSUS ON Helicobacter pylori

3rd BRAZILIAN CONSENSUS ON Helicobacter pylori

Anti‐Helicobacter pylori therapy in localized gastric mucosa‐associated lymphoid tissue lymphoma: A prospective, nationwide, multicenter study in Japan

Extranodal and splenic small B-cell lymphoma

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