Treatment outcome and prognostic factors of adult glioblastoma multiforme

Ahmadloo, Niloofar; Kani, Amir Abbas; Mohammadianpanah, Μohammad; Nasrolahi, Hamid; Omidvari, Shapour; Ahmad, Mansoor; Ansari, Mansour

doi:10.1016/j.jnci.2012.11.001

Cited by 51 publications

(42 citation statements)

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“…The median age of our patients was 50 years, which is younger than the median age of 7726 patients, reported as 62 years in the review of literature (Ahmadloo et al, 2013).…”

Section: Discussionmentioning

confidence: 51%

Efficacy of High Dose Radiotherapy in Post-operative Treatment of Glioblastoma Multiform - A Single Institution Report

Pashaki

Hamed²,

Mohamadian³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…The median age of our patients was 50 years, which is younger than the median age of 7726 patients, reported as 62 years in the review of literature (Ahmadloo et al, 2013).…”

Section: Discussionmentioning

confidence: 51%

Efficacy of High Dose Radiotherapy in Post-operative Treatment of Glioblastoma Multiform - A Single Institution Report

Pashaki

Hamed²,

Mohamadian³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…Family history (Kye et al, 2015), therapy at chest area (Ahmadloo et al, 2013;Tinari et al, 2015;Yu et al, 2015), are another significant factors for breast cancer mortality. Cancer of parents has higher priority to develop cancer for next generation than cancer of grandparents not only for breast cancer but also other cancers .…”

Section: Introductionmentioning

confidence: 99%

Association Assessment among Risk Factors and Breast Cancer in a Low Income Country: Bangladesh

Ahmed¹,

Asaduzzaman²,

Bashar³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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Background: In the low incoming country Bangladesh, breast cancer is second most common neoplasm and is increasing at an alarming rate among females. Lack of awareness and illiteracy are contributory factors for late presentation and therefore mortality. Purpose: To examine associations of different factors with breast cancer mortality and to raise awareness among the women of society in Bangladesh. Materials and Methods: This descriptive case-control study was conducted on 160 participants from April 2011 till July 2014. Through a valid questionnaire covering personal and family history, data were collected by face to face interview. For analyzing correlations among factors with breast cancer data, binary logistic regression, Pearson's χ2-value, odd ratios and p-value tests were conducted with SPSS version 20. Results: The mean age of the patients was 43.0 (SD=±11.12). In ascending order the leading significant factors were hormone therapy (p<0.0000, OR=4.897), abortion (p<0.0001, OR=3.452), early start menarche (p<0.0002, OR=3.500), family history (p<0.0022, OR=3.235), and late menopause (p<0.0093, OR=3.674) with both χ2 test and logistic regression analyses. Non-significant factors were cancer experience, fatty food habits, marital status and taking alcohol. Conclusions: Regarding the investigation of this study, significant and insignificant factor's correlation visualization with breast cancer will be helpful to increase awareness among Bangladeshi women as well as all over the world.

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“…According to the 2007 World Health Organization classification of central nervous system tumors, gliomas are divided pathologically into four grades, which are relevant for prognosis. Surgery, with or without radiotherapy and chemotherapy, can relieve many symptoms in glioma patients, but clinically, tumor recurrence often occurs (1). For many patients, complete elimination of gliomas remains a challenge.…”

Section: Introductionmentioning

confidence: 99%

Mammalian target of rapamycin signaling is involved in the vasculogenic mimicry of glioma via hypoxia-inducible factor-1α

Min

Sun

et al. 2014

Oncology Reports

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Abstract. The mammalian target of rapamycin (mTOR) is a crucial regulator in malignant gliomas. Vasculogenic mimicry (VM) describes functional channels established by highly malignant tumor cells that is different from endothelium-lined blood vessels. Our previous studies confirmed the existence and clinical significance of VM in medulloblastoma and glioblastoma. In the present study, by immunohistochemical and CD34/PAS histochemical double-staining, 34 cases (26.8%) with VM structures were identified among a total of 127 glioma cases, and these VM structures were associated with mTOR expression in the glioma specimens. In vitro, U87 malignant glioblastoma cells formed tube structures similar to HUVECs on Matrigel in 3D culture, and mTOR-specific inhibitor rapamycin inhibited VM formation in the U87 malignant glioblastoma cells under both normoxia and hypoxia. In addition, rapamycin and mTOR siRNA inhibited molecules in the signaling cascade of VM formation, particularly HIF-1α. Taken together, our results demonstrated that mTOR signaling is involved in VM formation, and may be a potential therapeutic target for gliomas.

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Treatment outcome and prognostic factors of adult glioblastoma multiforme

Abstract: The prognosis of adult patients with GBM remains poor; however, complete surgical resection and adjuvant treatments improve progression-free and overall survival.

Cited by 51 publications

References 50 publications

Efficacy of High Dose Radiotherapy in Post-operative Treatment of Glioblastoma Multiform - A Single Institution Report

Efficacy of High Dose Radiotherapy in Post-operative Treatment of Glioblastoma Multiform - A Single Institution Report

Association Assessment among Risk Factors and Breast Cancer in a Low Income Country: Bangladesh

Mammalian target of rapamycin signaling is involved in the vasculogenic mimicry of glioma via hypoxia-inducible factor-1α

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