Treatment outcome and patterns of failure in patients of pinealoblastoma: review of literature and clinical experience from a regional cancer centre in north India

Biswas, Ahitagni; Mallick, Supriya; Purkait, Suvendu; Gandhi, Ajeet Kumar; Sarkar, Chitra; Singh, Manmohan; Julka, Pramod Kumar; Rath, Goura Kishor

doi:10.1007/s00381-015-2751-1

Cited by 13 publications

(10 citation statements)

References 38 publications

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“…[63] For 17 patients with pinealoblastoma, the 2 years actuarial overall survival have been reported to be 85.6%. [64] Leptomeningeal spread at diagnosis was seen in 4 patients during presentation and age more than 8 years, and no metastasis were significant predictors for better relapse-free survival. For 44 patients with primary CNS lymphoma treated at TMH, overall survival was found to be 83% (ASNO 2013) treated with high-dose methotrexate and RT.…”

Section: Other Brain Tumorsmentioning

confidence: 96%

Indian data on central nervous tumors: A summary of published work

Dasgupta

Gupta

Jalali

2016

South Asian J Cancer

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Tumors of the central nervous system (CNS) constitute approximately 2% of all malignancies. Although relatively rare, the associated morbidity and mortality and the significant proportion of affected young and middle-aged individuals has a major bearing on the death-adjusted life years compared to other malignancies. CNS tumors encompass a very broad spectrum with regards to age, location, histology, and clinical outcomes. Advances in diagnostic imaging, surgical techniques, radiotherapy equipment, and generation of newer chemotherapeutic and targeted agents over the past few years have helped improving treatment outcome. Further insights into the molecular pathways leading to the development of tumors made in the past decade are being incorporated into routine clinical practice. Several focused groups within India have been working on a range of topics related to CNS tumors, and a significant body of work from India, in the recent years, is being increasingly recognized throughout the world. The present article summarizes key published work with particular emphasis on gliomas and medulloblastoma, the two commonly encountered tumors.

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Section: Other Brain Tumorsmentioning

confidence: 96%

Indian data on central nervous tumors: A summary of published work

Dasgupta

Gupta

Jalali

2016

South Asian J Cancer

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“…Lee et al did not find any impact of CT on survival, but the analysis was limited by the small number of patients and the many different regimens used [10]. In a series of 17 PBs by Biswas et al, the most common regimen was a combination of Carboplatin and Etoposide [17]. Brandes et al suggest that patients should be stratified according to recurrence risk when planning adjuvant treatment [18].…”

Section: Discussionmentioning

confidence: 99%

Pineoblastoma in Adults: A Rare Case Successfully Treated with Multimodal Approach Including Craniospinal Irradiation Using Helical Tomotherapy

Gaito¹,

Malagoli²,

Depenni³

et al. 2019

Cureus

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Pineoblastomas (PBs) are rare and aggressive malignancies of the pineal gland. They are more commonly diagnosed in children between 1-12 years old, and are very rarely diagnosed in adults. For this reason, evidence in literature for adults is scarce and mainly derives from the paediatric practice. For their clinical behaviour and embryonal histology, PBs are often grouped together with medulloblastomas in clinical trials. In this report, we describe an adult PB case who was treated at our institution. We reference the literature to explain the clinical reasoning behind our decision-making process.A 46-year-old male patient was referred to our institution in November 2015 with three months history of headache. Imaging confirmed localised disease of the pineal gland. He underwent surgery which was radical and clinically uncomplicated. Histology showed PB. He then received adjuvant craniospinal radiotherapy with a boost to the tumour bed followed by consolidation chemotherapy. After 36 months follow-up, he remains disease-free without significant toxicities.Surgery followed by craniospinal irradiation and consolidation chemotherapy can be a safe and effective treatment option in adult PBs.

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“…3 – 5 As a result of such an exceedingly low incidence of PBs in the general population, considerable dispute over factors affecting the prognosis and treatment strategies was present. 6 , 7 In addition, the relationship of clinical behaviors between age-related subgroups was not identified. Therefore, this study aimed to explore adverse factors of overall survival (OS), multimodal treatment outcomes, and different clinical distributions between pediatric and adult patients based on our experience with surgical treatment in an institution.…”

Section: Introductionmentioning

confidence: 99%

<p>Adverse Factors of Treatment Response and Overall Survival in Pediatric and Adult Patients with Pineoblastoma</p>

Huo

Wang

Zhang

et al. 2020

CMAR

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Intracranial pineoblastomas are rare neoplasms with poor prognosis. The aim of this study was to describe the independent prognostic factors and treatment strategies for overall survival in pediatric and adult patients. Methods: Sixty-four patients were surgically treated between January 2012 and December 2018. Results: The series included 37 (57.8%) males and 27 (42.2%) females. Gross total resection was achieved in 41 (64.1%) cases, and the 1-, 3-, and 5-year rates of overall survival were 86.3, 52.3, and 36.6%, respectively. In the pediatric group (n=42), 28 patients (66.7%) were male, with the median, and the mean age was 4 and 6.2±4.7 years, respectively. After a median follow-up of 25.0 months, twenty-six patients (61.9%) died, and the 1-, 3-, and 5-year rates of overall survival were 84.9, 46.4, and 26.7%, respectively. Postoperative radiotherapy (p=0.058) and postoperative chemotherapy (p=0.183) had a positive influence on the increased overall survival. Meanwhile, postoperative radiotherapy combined with chemotherapy following surgery had a positive impact on overall survival (p=0.174, Log rank). In the adult group, the mean overall survival was 67.3±9.3 months (range, 0.8-95.3 months), and the 1-, 3-, and 5-year rates of overall survival were 89.5, 64.4, and 64.4%, respectively. In this group, no statistical association was observed between clinical factors and outcomes. However, patients who received postoperative radiotherapy (60.7 vs 57.6 month, mean survival; p=0.510, Log rank) or chemotherapy (63.0 vs 59.9 month, mean survival; p=0.404, Log rank) had better survival rates compared with those who declined. Conclusion: In the pediatric group, surgery with postoperative radiotherapy and chemotherapy was a favorable factor for overall survival. In the adult group, a positive trend in overall survival was found when patients received radiation and/or chemotherapy following surgery.

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Treatment outcome and patterns of failure in patients of pinealoblastoma: review of literature and clinical experience from a regional cancer centre in north India

Cited by 13 publications

References 38 publications

Indian data on central nervous tumors: A summary of published work

Indian data on central nervous tumors: A summary of published work

Pineoblastoma in Adults: A Rare Case Successfully Treated with Multimodal Approach Including Craniospinal Irradiation Using Helical Tomotherapy

<p>Adverse Factors of Treatment Response and Overall Survival in Pediatric and Adult Patients with Pineoblastoma</p>

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