Treatment Options for Sexual Dysfunction in Patients with Chronic Kidney Disease

Vecchio, Mariacristina; Navaneethan, Sankar D.; Johnson, David W.; Lucisano, Giuseppe; Graziano, Giusi; Querques, Marialuisa; Saglimbene, Valeria; Ruospo, Marinella; Bonifati, Carmen; Jannini, Emmanuele A.; Strippoli, Giovanni F.M.

doi:10.2215/cjn.09081209

Cited by 56 publications

(40 citation statements)

References 49 publications

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“…Overall, three quarters of men on hemodialysis experience erectile dysfunction (8). Although phosphodiesterase-5 inhibitors improve erectile function in men with CKD, only a few small trials have evaluated such interventions (9).…”

Section: Introductionmentioning

confidence: 99%

Sexual Dysfunction in Women with ESRD Requiring Hemodialysis

Strippoli

Depression

2012

Clinical Journal of the American Society of Nephrology

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SummaryBackground and objectives The few existing studies of sexual dysfunction in women on hemodialysis are limited by small sample size. This large, cross-sectional study evaluated the prevalence and correlates of female sexual dysfunction in advanced kidney disease.Design, setting, participants, & methods A total of 1472 women with ESRD undergoing hemodialysis were recruited to a multinational, cross-sectional study conducted within a collaborative dialysis network in Europe and South America. Sexual dysfunction was identified by the Female Sexual Function Index. Correlates of selfreported sexual dysfunction were identified by regression analyses.Results Of the 1472 women, 659 completed questionnaires (45% Conclusions This descriptive study suggests most women on hemodialysis experience sexual problems. Additional research on the relevance of sexual dysfunction to symptom burden and quality of life in these women is needed.

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Section: Introductionmentioning

confidence: 99%

Sexual Dysfunction in Women with ESRD Requiring Hemodialysis

Strippoli

Depression

2012

Clinical Journal of the American Society of Nephrology

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“…Moreover, the nicotine in cigarettes causes a decrease in ovarian follicles, reduces the movements of cilia of uterus, reduces testosterone and causes premature menopause (18).…”

Section: Discussionmentioning

confidence: 99%

“…The highest score for each dimention was 6 and the scores for all the scales are 36. International Index of Erectile Function Inventory scoring for men was mild impotence (21-25), average impotence (16)(17)(18)(19)(20), advanced impotence (10-15) and severe impotence (5)(6)(7)(8)(9)(10).…”

Section: Methodsmentioning

confidence: 99%

Investigating the Effects of Lifestyle Changes on Sexual Function of Patients Undergoing Hemodialysis Procedures

Kazemi

Ziaeirad

Zarea

et al. 2016

Jundishapur J Chronic Dis Care

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Background: Hemodialysis patients with chronic renal failure experience a variety of sexual disorders that result in self-dissatisfaction, undermining self-care, and decrease in quality of life. Objectives: The present study aimed at investigating the effects of lifestyle changes on the sexual function of patients undergoing hemodialysis. Patients and Methods:In a mono group quasi-experimental study, 37 subjects (21 males and 16 females) were selected among available patients using convenience sampling. The population included all the patients undergoing hemodialysis treatment in the year 2015. The tools of research included a demographic questionnaire, questionnaires assessing female sexual function and standard questionnaires for male patients. All the questionnaires were completed by the researcher. The subjects were individually instructed to introduce changes to their lifestyles for three days including their eating habits, exercising, and quitting smoking. The participants were asked to implement these changes for a period of 8 weeks at the end of which they would have to complete sexual function questionnaires again. The data obtained were analyzed by paired-t test, frequency percentage, and mean using SPSS (ver.21). Results:The results indicate that average sexual function of women before and after intervention were 46.12 and 58.62, respectively. The same variable for men was 45.88 and 65.11 for before and after the intervention, respectively. Paired t-test was performed for comparison of pre-and postintervention sexual function in women with significance levels of P < 0.001 and P < 0.005, respectively. Conclusions: Improvements in certain aspects of lifestyle may significantly improve sexual function in patients undergoing hemodialysis treatment without excessive usage of resources. Therefore, introducing specific improvements in the lifestyles of patients undergoing hemodialysis is of considerable importance.

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“…In several RCTs for treatment of sexual dysfunction in patients with CKD, treatment with sildenafil and vardenafil is associated with improvement in the overall score of IIEF-5, an increase of the score of all individual IIEF-5 tool domains (erection frequency, erection quality, penetration ability, maintenance frequency of penetration, maintenance of erection after penetration and erection confidence) compared to placebo and an increase of the overall satisfaction score of the IIEF-15 sexual assessment tool. For the use of other agents such as tadalafil or mirodenafil in CKD patients data is limited [61] . Sildenafil citrate is also considered an important first-line therapeutic option among kidney transplant recipients with sexual dysfunction as it has no effect on renal function or immunosuppressive drug levels [62] .…”

Section: First Line Therapy-oral Pharmacotherapymentioning

confidence: 99%

Erectile dysfunction in chronic kidney disease: From pathophysiology to management

Papadopoulou

Varouktsi

Lazaridis

et al. 2015

WJN

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Chronic kidney disease (CKD) is encountered in millions of people worldwide, with continuously rising incidence during the past decades, affecting their quality of life despite the increase of life expectancy in these patients. Disturbance of sexual function is common among men with CKD, as both conditions share common pathophysiological causes, such as vascular or hormonal abnormalities and are both affected by similar coexisting comorbid conditions such as cardiovascular disease, hypertension and diabetes mellitus. The estimated prevalence of erectile dysfunction reaches 70% in end stage renal disease patients. Nevertheless, sexual dysfunction remains under-recognized and under-treated in a high proportion of these patients, a fact which should raise awareness among clinicians. A multifactorial approach in management and treatment is undoubtedly required in order to improve patients' quality of life and cardiovascular outcomes.

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Treatment Options for Sexual Dysfunction in Patients with Chronic Kidney Disease

Abstract: Background and objectives: Sexual dysfunction is very common in patients with chronic kidney disease (CKD),

Cited by 56 publications

References 49 publications

Sexual Dysfunction in Women with ESRD Requiring Hemodialysis

Sexual Dysfunction in Women with ESRD Requiring Hemodialysis

Investigating the Effects of Lifestyle Changes on Sexual Function of Patients Undergoing Hemodialysis Procedures

Erectile dysfunction in chronic kidney disease: From pathophysiology to management

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