Treatment options for androgenetic alopecia: Efficacy, side effects, compliance, financial considerations, and ethics

Nestor, Mark S.; Ablon, Glynis; Gade, Anita; Han, Haowei; Fischer, Daniel L.

doi:10.1111/jocd.14537

Cited by 111 publications

(111 citation statements)

References 171 publications

(341 reference statements)

Supporting

Mentioning

105

Contrasting

Unclassified

Order By: Relevance

“…The slight physical trauma caused by the microneedles can induce collagen formation and form pore channels to enhance local drug penetration. 23 In percutaneous collagen induction, the tissue response is highly dependent on the depth and density of the perforations, and different approaches of micro-acupuncture insertion will also trigger different skin physiological responses. Furthermore, the microneedles promote continuous epidermal thickening, normalize the polarity of the nuclei at the basal layer, reduce the degeneration of solar elastic tissue, and increase the collagen types I, III, and IV (a component of the basement membrane).…”

Section: Discussionmentioning

confidence: 99%

Observation on the Efficacy of a Combined Treatment for Moderate and Severe Androgenetic Alopecia Incorporating Electric Microneedles

Zhang¹,

Yang²,

Feng³

et al. 2022

CCID

View full text Add to dashboard Cite

Objective To evaluate the effectiveness and safety of a combined treatment for moderate and severe androgenetic alopecia (AGA) involving the use of electric microneedles. Methods A total of 83 patients with moderate to severe AGA in the Department of Dermatology at Beijing Jishuitan Hospital were included in this study. The male patients were administered finasteride orally and 5% minoxidil for external use, while the female patients were given spironolactone orally or Diane-35 and 2% minoxidil for external use. All the patients were then treated via electric microneedle therapy alongside the YUFA ® medical care package (Foshan, China) once a week for 1–28 weeks. The seven-point method and root hair measurement using a hair mirror were adopted to evaluate the efficacy and any adverse reactions of the combined treatment. Results Eleven patients were treated for 1–3 weeks, 60 for 4–12 weeks, and 12 for more than 12 weeks. The efficacy evaluation using the seven-point method for 12 weeks of treatment indicated a 100% response rate, specifically, a 42.1% mild improvement rate, a 38.6% moderate improvement rate, and a 19.3% marked improvement rate. Besides, the efficacy assessment was also completed with root hair count method and the number of hair roots measured at fixed points were 148.67±11.15, 158.13±5.11 and 169.75±2.06 after treatment time at 16, 20 and 24 weeks, respectively. Of note, a statistical difference in the number of hair roots could be observed during the period of week 20–week 24 ( P < 0.01). Conclusion The combined treatment of moderate to severe AGA using the electric microneedle technique has a clear effect and can effectively increase the hair density. With a simple operation and mild side effects, the technique has wide application prospects.

show abstract

Section: Discussionmentioning

confidence: 99%

Observation on the Efficacy of a Combined Treatment for Moderate and Severe Androgenetic Alopecia Incorporating Electric Microneedles

Zhang¹,

Yang²,

Feng³

et al. 2022

CCID

View full text Add to dashboard Cite

show abstract

“…Transient increased hair loss is the other side effect of this medication 8 . Due to its limited effect on AGA, many patients discontinue minoxidil after a few months of treatment 9,10 …”

Section: Discussionmentioning

confidence: 99%

“…8 Due to its limited effect on AGA, many patients discontinue minoxidil after a few months of treatment. 9,10 Finasteride is a 5-alpha-reductase inhibitor that prevents conversion of the testosterone to dihydrotestosterone. Finasteride is teratogen and its temporary, negative effect on sexual function is well-known.…”

Section: Discussionmentioning

confidence: 99%

Comparison between “5% minoxidil plus 2% flutamide” solution vs. “5% minoxidil” solution in the treatment of androgenetic alopecia

Faghihi

Iraji

Siadat

et al. 2022

J of Cosmetic Dermatology

View full text Add to dashboard Cite

Background Androgenetic alopecia is defined as a patterned hair loss resulting from the effect of androgen on hair follicles and characterized by non‐scarring, progressive miniaturization of the hair follicles. Minoxidil and finasteride are regarded as the first‐line treatments with antiandrogens and flutamide are considered as the alternative choices. In the current study, we evaluated the efficacy of combination therapy with topical 2%flutamide plus 5% minoxidil vs. %5 minoxidil alone in the treatment of the androgenetic alopecia. Material and Methods This was a randomized, double‐blinded clinical trial in 40 patients with androgenetic alopecia. Patients were randomized to receive either topical minoxidil vs. topical flutamide plus minoxidil for 6 months. At the end of study, patients were compared regarding mean hair density and mean hair thickness and patient's satisfaction. Collected data were analyzed using t‐test, Ki square, and Kolmogorov–Smirnov tests. Results Topical flutamide plus minoxidil solution was significantly more effective than minoxidil in terms of hair density, hair thickness, and patient's satisfaction (p < 0.05). Conclusion Topical hydroalcoholic solution of flutamide plus minoxidil may be promising treatment for the androgenetic alopecia. To better evaluate the efficacy of topical flutamide, more prolonged studies with higher number of patients and use of different vehicles and different ingredients are recommended.

show abstract

“…Finasteryd jest powszechnie stosowany w leczeniu łysienia androgenowego od 1997 roku. Lek ten występuje w dawce 1 mg i 5 mg, przy czym niższa dawka jest zalecana w leczeniu łysienia typu męskiego [25]. Finasteryd jest kompetycyjnym odwracalnym inhibitorem 5-alfa reduktazy typu I i typu II, który znajduje się między innymi w mieszkach włosowych, prostacie, pęcherzykach nasiennych, najądrzach, nasieniowodzie [26,27,28].…”

Section: Opis Stanu Wiedzyunclassified

Pharmacotherapy of androgenetic alopecia – a literature review

Marcin

Pożarowska²,

Rosińska³

et al. 2022

J Educ Health Sport

View full text Add to dashboard Cite

INTRODUCTION: Androgenetic alopecia, also known as male pattern baldness, is a common dermatological problem. It manifests as hair thinning and miniaturization of hair follicles. In recent years, knowledge of the risk factors and pathomechanisms of this disease has increased, making treatment more effective. Serious consequences of this condition include reduced quality of life and patient self-esteem. PURPOSE OF THE WORK: The purpose of this paper is to review and discuss selected studies involving agents used in the pharmacotherapy of androgenetic alopecia and to evaluate their safety and efficacy. DESCRIPTION OF THE STATE OF KNOWLEDGE: There are two drugs approved by the Food and Drug Administration (FDA) for the treatment of androgenetic alopecia - oral finasteride 1 mg and 2% or 5% minoxidil solution for topical use. There are also other preparations for external use, such as 0.1% finasteride solution or ketoconaloze shampoo, and for oral use, dutasteride. They seem to be a promising alternative for the treatment of androgenetic alopecia, but require further research. It is possible to use one drug of choice or to use combination therapy to achieve better therapeutic effects. SUMMARY: In order to achieve the best and fastest treatment results, patients should be treated with combination therapy consisting of two or more preparations. To reduce systemic side effects, consider using several topical preparations.

show abstract

Treatment options for androgenetic alopecia: Efficacy, side effects, compliance, financial considerations, and ethics

Abstract: This is an open access article under the terms of the Creat ive Commo ns Attri bution-NonCo mmercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

Cited by 111 publications

References 171 publications

Observation on the Efficacy of a Combined Treatment for Moderate and Severe Androgenetic Alopecia Incorporating Electric Microneedles

Observation on the Efficacy of a Combined Treatment for Moderate and Severe Androgenetic Alopecia Incorporating Electric Microneedles

Comparison between “5% minoxidil plus 2% flutamide” solution vs. “5% minoxidil” solution in the treatment of androgenetic alopecia

Pharmacotherapy of androgenetic alopecia – a literature review

Contact Info

Product

Resources

About