Treatment of vitiligo by 308‐nm excimer laser: An evaluation of variables affecting treatment response

Abstract

An aesthetically reasonable result is achieved essentially in "UV sensitive" areas, thus appearing to be the appropriate places of choice for this treatment.

Targeted Broadband UVB Phototherapy forthe Treatment of Localized Vitiligo

“…Many authors [9][10][11][12] have consistently reported that response to therapy is highly dependent on lesion location, a finding confirmed by the present study. It is believed that inactive melanocytes in the outer root sheath of the hair follicles are stimulated to proliferate and migrate by the irradiation and cause repigmentation [18][19][20] .…”

“…Although NB-UVB radiation has been shown to be most efficacious and has a low side-effect profile, reported treatment series required six to twelve months of treatment to achieve optimal results. More recently, several authors have found that microphototherapy or targeted phototherapy offers benefits [9][10][11][12][13][14][15][16][17] , which include the rapid onset of repigmentation, good overall response in terms of repigmentation area, and a lower number of treatment sessions than conventional NB-UVB to achieve satisfactory results. It should also be noted that targeted phototherapy can be used to selectively irradiate vitiligo patches without involving neighboring healthy skin.…”

“…Several reports have shown successful results for 308-nm excimer lasers, which are costly and difficult to maintain, or using light with a wavelength that lies close to that of NB-UVB [9][10][11][12][13][14] . Our purpose in this study was to examine the feasibility of a targeted UVB light JE Kim, et al Vol.…”

Vitiligo: A comprehensive overview

“…When used as monotherapy, repigmentation rates of more than 75% are seen in 16.6% to 52.8% of patients; response rates are as high as 95%. [83][84][85][86] On average, it takes 11 to 22 sessions to see repigmentation, more in poorly responsive acral areas. 87,88 The onset of repigmentation negatively correlates with the total number of treatments.…”

Vitiligo in Children and Adolescents: a Lliterature Review / Vitiligo kod dece i omladine - pregled literature

“…Excimer laser phototherapy (308 nm) has proven successful in localized vitiligo in adults (efficacy of 53%), with less adverse effects in regard to PUVA therapy, but further investigations are needed concerning its safety in children (47,48).…”