Targeted Broadband UVB Phototherapy forthe Treatment of Localized Vitiligo

Abstract

Background: Several new treatments appear to have higher success rates than previous therapies for the treatment of vitiligo, and targeted phototherapy is an alternative that may prove to be time-efficient and an effective therapeutic option for the management of this condition.Objective: The aim of this study was to evaluate the efficacy of targeted broadband UVB phototherapy for the treatment of localized vitiligo.Methods: Fifty-three vitiliginous patches on thirty-five patients (16 males, 19 females) were treated using a targeted broadband UVB phototherapy device. Treatment was started at 70% of the minimal erythema dose, and then gradually increased. Lesions were treated twice a week for a maximum of 60 treatment sessions.Results: Subjects tolerated treatment well. Forty-one of the fifty-three patches (77.4%) achieved repigmentation on ≥75% of the treated areas. Best results were obtained on the face and neck; 20 of the 24 patches (83.3%) concerned achieved ≥75% repigmentation. The least response was on the hands and feet; 3 of 6 patches (50%) showed ≥75% repigmentation. The results were better for focal type than segmental type vitiligo.Conclusion: Targeted broadband UVB phototherapy appears to be highly effective at restoring pigmentation in patients with localized vitiligo. (Ann Dermatol (Seoul) 20(3) 107∼112, 2008)

Development of UVB LED Lighting System Based on UV Dose Calculation Algorithm to Meet Individual Daily UV Dose

“…However, such methods only either suggest to the user a duration for outdoor activity or provide passive information about estimated amounts of UV and vitamin D synthesis. On the other hand, Chandra verified the vitamin D synthesis effect on vitamin D deficient patients by using a commercial tanning device with an artificial UV light source, and a UV special lighting device was developed that provides a UVB dose to parts of the body for skin treatment [17,18]. Research has also been carried out on the development of UVB Light Emitting Diode (LED) indoors lighting, which provides harmless levels of UVB light [19].…”