Treatment of unknown primary melanoma

Velez, Augustine; Walsh, Debra; Karakousis, Constantine P.

doi:10.1002/1097-0142(19911215)68:12<2579::aid-cncr2820681209>3.0.co;2-g

Cited by 41 publications

(22 citation statements)

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“…This percentage is in agreement with that reported by other studies [3][4][5][6], although the incidence of unknown primary is estimated to be approximately 8-9% by authors that take into account only patients with lymph node involvement [7,16]. In our experience, in agreement with the majority of published series [3,4,17,18], patients with unknown primary were predominantly middle-aged males. In almost half of the cases, the first site of presentation was a lymph nodal mass, but also cutaneous or subcutaneous localizations were frequent; on the contrary, visceral metastases were found at diagnosis in only 18% of patients.…”

Section: Discussionmentioning

confidence: 99%

Melanoma of unknown primary site: a 33-year experience at the Turin Melanoma Centre

et al. 2010

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This is an author version of the contribution published on:Questa è la versione dell'autore dell'opera: AbstractUnknown melanoma occurs as metastasis to skin, nodes or viscera, without a detectable cutaneous primary tumour. We reviewed our database of 4881 melanoma patients, diagnosed and followed up prospectively for a 33-year period. We identified 93 cases of metastatic melanoma without evidence of primary; however, five of these patients had a history of a previous excision of a presumed benign lesion without histological examination and were excluded from analyses. At diagnosis, metastases were cutaneous in 35.3% of cases, nodal in 43.2% and visceral in 17% of cases; in 4.5% of patients, both skin and nodes were involved. In all cases, clinical inspection and staging procedures performed at diagnosis of metastatic disease failed to identify a primary melanoma. In 11 cases (11.8%), extensively regressed pigmented lesions (without evidence of melanoma cells at the histological examination) were documented; moreover, we identified in our series five patients with unknown primary affected by vitiligo. The 5-year and 10-year overall survival rates were 49.6 and 41.4%, respectively, with a median of 4.9 years. The 5-year and 10-year time to progression rates were 39.4 and 32.3%, respectively, with a median of 2.3 years. Survival was longer in females and showed significant differences among patients with skin, lymph node or visceral involvement at diagnosis. In melanoma patients, unknown primary represents a not so rare event, with an uncertain origin. We confirmed the relatively good prognosis of unknown primary melanoma patients, a fact that has to be taken into consideration for their management.

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Section: Discussionmentioning

confidence: 99%

Melanoma of unknown primary site: a 33-year experience at the Turin Melanoma Centre

et al. 2010

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“…Metastatic melanoma with an unknown primary is a rare lesion and the incidence has been variously reported between 2-10% [2,3]. Metastatic deposits to various sites have been reported including sites like the brain and lymph nodes [3][4][5].…”

Section: Discussionmentioning

confidence: 99%

“…Metastatic deposits to various sites have been reported including sites like the brain and lymph nodes [3][4][5]. The prognosis of this condition is still controversial, although studies indicate that there is no difference in prognosis when compared to cases where the primary tumour has been identified [2].…”

Section: Discussionmentioning

confidence: 99%

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Metastatic Amelanotic Malignant Melanoma with Unknown Primary - A Case Report

Moorchung¹,

Mukherjee

Srinivas

et al. 2004

Medical Journal Armed Forces India

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“…Os melanomas primários de órbita são extremamente raros pois a órbita é desprovida de melanócitos (2)(3)(4)(5) . Dessa maneira os melanomas orbitários são, em sua grande maioria, secundários a melanomas uveais ou conjuntivais (2,6) .…”

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Melanoma em cavidade anoftálmica secundária a evisceração: relato de 2 casos e revisão da literatura

Akaishi¹,

Kitagawa²,

Chahud³

et al. 2004

Arq. Bras. Oftalmol.

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Melanoma em cavidade anoftálmica secundária a evisceração -Relato de 2 casos e revisão da literatura Os autores relatam 2 casos de pacientes com melanoma em cavidade anoftálmica secundária a eviscerações ocorridas há 30 e 60 anos. Em ambos os casos a análise histopatológica mostrou que o tumor estava aderido a remanescentes esclerais. A implicação desses casos foi discutida no contexto das indicações de evisceração e enucleação. INTRODUÇÃOMelanomas são tumores malignos derivados de melanócitos da crista neural. Essas células estão presentes na epiderme, derme, tecido conjuntival e uveal (1) .Os melanomas primários de órbita são extremamente raros pois a órbita é desprovida de melanócitos (2)(3)(4)(5) . Dessa maneira os melanomas orbitários são, em sua grande maioria, secundários a melanomas uveais ou conjuntivais (2,6) . Em cavidades anoftálmicas, os melanoma orbitários são, em geral, decorrentes de recidiva de melanomas uveais de olhos previamente enucleados (7) . Sabe-se que a recorrência orbitária após a enucleação ocorre em 3% dos casos dos melanomas restritos ao compartimento intra-ocular e em 18% dos casos nos quais há evidências histológicas de extensão extraescleral (8) . A recidiva orbitária pode ocorrer até 42 anos após a enucleação (9) . Na ausência de história pregressa de melanoma, o diagnóstico da origem do tumor nas cavidades anoftálmicas é, às vezes, bastante difícil e depende dos achados clínicos e histopatológicos.No presente trabalho apresentamos 2 casos de melanoma em cavidades anoftálmicas após eviscerações ocorridas, por causas desconhecidas, há 30 e 60 anos. Discutimos as prováveis origens do melanoma e os dados da literatura sobre o assunto. RELATO DE CASOS Caso 1:Paciente do sexo masculino, 64 anos, apresentou massa em cavidade anoftálmica esquerda há 5 meses, com crescimento progressivo e sangramento da lesão. O olho esquerdo foi eviscerado na infância devido à perda visual associada à inflamação de causa desconhecida. Ao exame apresentava massa endurecida e protrusa em órbita esquerda. A tomografia RELATOS DE CASOS

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Treatment of unknown primary melanoma

Cited by 41 publications

References 13 publications

Melanoma of unknown primary site: a 33-year experience at the Turin Melanoma Centre

Melanoma of unknown primary site: a 33-year experience at the Turin Melanoma Centre

Metastatic Amelanotic Malignant Melanoma with Unknown Primary - A Case Report

Melanoma em cavidade anoftálmica secundária a evisceração: relato de 2 casos e revisão da literatura

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