Metastatic Amelanotic Malignant Melanoma with Unknown Primary - A Case Report

Moorchung, Nikhil; Mukherjee, Bhramar; Srinivas, V.; Subramanya, H

doi:10.1016/s0377-1237(04)80070-4

Cited by 4 publications

(10 citation statements)

References 5 publications

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“…Melanomas can show both epitheloid as well as spindle cell morphology with alveolar pattern or cells in sheets. The immunoexpression of S-100 and HMB-45 protein is usually confirmatory for melanoma [3,5,7]. The correct diagnosis in our case was also complicated by absence of primary lesion in the patient, markedly anaplastic and dedifferentiated epitheloid cellular morphology with bizarre giant cells, complete absence of melanin pigment and focal rhabdoid morphology.…”

Section: Discussionmentioning

confidence: 56%

“…Lymphoma, melanoma, ovarian tumors, pulmonary malignancies, gastrointestinal and genitourinary tract tumors, and brain tumors are important primary tumors with breast metastasis [5,7]. Although melanoma comprises a major fraction of the metastatic tumors to the breast, it is a rare site for it to metastasize [2].…”

Section: Discussionmentioning

confidence: 99%

“…Although melanoma comprises a major fraction of the metastatic tumors to the breast, it is a rare site for it to metastasize [2]. It is also known to metastasize years after excision of the primary tumor [2] or without any detectable primary [5,6,8]. Amelanotic variant of melanoma is rare and show minimal or complete absence of pigment in tumor cells [4,5].…”

Section: Discussionmentioning

confidence: 99%

“…Such a suspicion is, however, lacking in case of a metastasis in the absence of a known primary, especially metastatic melanomas. The absence of pigment and varying cellular morphology with high-grade anaplastic cellular features, known to occur in melanomas, further complicates the process of correctly diagnosing the lesion [5,7]. Melanomas can show both epitheloid as well as spindle cell morphology with alveolar pattern or cells in sheets.…”

Section: Discussionmentioning

confidence: 99%

“…[2,3] Poorly differentiated forms of melanoma may not be pigmented and difficult to recognize morphologically; such a variant is referred to as amelanotic melanoma. [4] Metastatic melanoma with unknown primary origin is uncommon, constituting 1-10% of all melanomas [5,6].…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Unusual presentation of metastatic amelanotic melanoma of unknown primary origin as a solitary breast lump

Dhingra¹,

Mandal²,

Khurana³

2008

Melanoma Research

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Breast is an uncommon site for metastasis from other malignancies especially melanomas. A 40-year-old lady presented with a rapidly growing, painless, solitary breast lump for 3 months. Past history was unremarkable for skin lesions, biopsy or any surgery. The lump was hard and freely mobile with normal overlying skin, nipple, and areola. Careful examination of the skin did not reveal any lesion. Grossly the tumor was partially circumscribed and gray white. Microscopically, a highly cellular lesion was seen showing nests and sheets of large anaplastic cells with atypical mitotic figures without any evidence of cytoplasmic pigment. Immunoreactivity for S-100 and HMB-45, confirmed the diagnosis of amelanotic melanoma. It is important to be aware of this atypical presentation of amelanotic melanoma in the breast and to utilize immunohistochemistry to differentiate from other commoner high-grade malignant tumors.

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Section: Discussionmentioning

confidence: 56%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Unusual presentation of metastatic amelanotic melanoma of unknown primary origin as a solitary breast lump

Dhingra¹,

Mandal²,

Khurana³

2008

Melanoma Research

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Cytomorphologic features of primary anaplastic large cell lymphoma of the psoas muscle: A case report and literature review

Recavarren

Yang

2009

Diagnostic Cytopathology

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Ki-1 (CD30) positive anaplastic large cell lymphoma (ALCL) is an uncommon malignancy, which may present with nodal as well as extra-nodal disease. Primary skeletal muscle Ki-1 (CD30) positive ALCL is an even rarer event with few cases reported in the literature and only some with published cytomorphologic features. An 83-year-old woman underwent a fine needle aspiration (FNA) of a psoas muscle mass. Smears demonstrated a predominantly discohesive population of large pleomorphic cells. The nuclei were hypechromatic and lobulated, with often multinucleation. Nucleoli were prominent in a subset of cells. Cytoplasmic vacuolization was also present. No lymphoglandular bodies were identified. A cytodiagnosis of malignant cells favoring metastatic melanoma vs. poorly differentiated carcinoma was rendered. Morphologic and immunohistochemical features later revealed a primary psoas muscle Ki-1 (CD30) positive ALCL with negative staining for anaplastic large cell lymphoma kinase (ALK). Cytologic features of ALCL mimic epithelial neoplasms, sarcomas, melanoma and other lymphomas. Although rare, ALCL should be a diagnostic consideration when discohesive pleomorphic malignant cells are encountered on FNA of a muscle neoplasm.

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Metastatic Melanoma of Unknown Primary Presenting with Multiple Cutaneous Nodules

Samanta¹,

Sharma²,

Yathiraj³

et al. 2019

APALM

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Melanoma usually present as well-known primary lesions. Rarely, they present with the lymph node, subcutaneous or visceral involvement without evidence of any primary lesion. In such cases they are called Melanoma of unknown primary site (MUP). Melanoma are fast growing cancers. Many environmental and genetics factors predispose to their development.We report a case of multiple subcutaneous swellings all over the body in a 42 year male, without any primary skin lesions. Histopathology and immunohistochemistry of these lesions confirmed them to be melanoma. Even after extensive search no primary tumour could be found in the patient.

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Metastatic Amelanotic Malignant Melanoma with Unknown Primary - A Case Report

Cited by 4 publications

References 5 publications

Unusual presentation of metastatic amelanotic melanoma of unknown primary origin as a solitary breast lump

Unusual presentation of metastatic amelanotic melanoma of unknown primary origin as a solitary breast lump

Cytomorphologic features of primary anaplastic large cell lymphoma of the psoas muscle: A case report and literature review

Metastatic Melanoma of Unknown Primary Presenting with Multiple Cutaneous Nodules

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