Treatment of Tuberculosis With Streptomycin

Hinshaw, Corwin H.; Feldman, William H.; Pfuetze, Karl H.

doi:10.1001/jama.1946.02870480024007

Cited by 131 publications

(17 citation statements)

References 5 publications

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“…While damage inflicted by AG on the kidney is usually reversible [8, 9], damage to the inner ear is permanent [10]. This nephro- and ototoxicity was initially discovered in the first clinical trials of streptomycin [11, 12]. Within the inner ear, streptomycin preferably damages the vestibular organ [12].…”

Section: Introductionmentioning

confidence: 99%

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Mechanisms of Aminoglycoside Ototoxicity and Targets of Hair Cell Protection

Huth

Ricci

Cheng

2011

International Journal of Otolaryngology

325

302

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Aminoglycosides are commonly prescribed antibiotics with deleterious side effects to the inner ear. Due to their popular application as a result of their potent antimicrobial activities, many efforts have been undertaken to prevent aminoglycoside ototoxicity. Over the years, understanding of the antimicrobial as well as ototoxic mechanisms of aminoglycosides has increased. These mechanisms are reviewed in regard to established and potential future targets of hair cell protection.

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Section: Introductionmentioning

confidence: 99%

“…This nephro- and ototoxicity was initially discovered in the first clinical trials of streptomycin [11, 12]. Within the inner ear, streptomycin preferably damages the vestibular organ [12]. Modification of streptomycin to dihydrostreptomycin, however, resulted in a shift of ototoxic damage from the vestibular organ to the cochlea [13].…”

Section: Introductionmentioning

confidence: 99%

Mechanisms of Aminoglycoside Ototoxicity and Targets of Hair Cell Protection

Huth

Ricci

Cheng

2011

International Journal of Otolaryngology

325

302

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“…In guinea pigs, it took six months of therapy to bring “the disease to a state of apparent arrest,” and evidence suggested eradication of bacilli in just 30% of the animals. 9 The two researchers responsible for these initial findings, Corwin Hinshaw and William Feldman, established the general understanding of streptomycin’s therapeutic capacity. When writing about their discovery of streptomycin’s clinical effects on TB, they noted that the drug “did not appear to possess any rapidly curative action in tuberculosis, such as might resemble the therapeutic marvels achieved by several antibacterial drugs against some acute infectious diseases.” 10 …”

Section: The Emerging Antibiotic Eramentioning

confidence: 99%

“…11 Although it was not the “ideal remedy for treatment of tuberculosis,” researchers still deemed the drug “remarkable” given that it was the only way to slow the progression of the lethal disease. 9 …”

Section: The Emerging Antibiotic Eramentioning

confidence: 99%

Walsh McDermott and Changing Conceptions of Tuberculosis Antibiotic Therapy

Pohl

Fins

2014

Academic Medicine

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Although health care reform efforts are laudably directed at promoting quality and efficiency, added bureaucracy may have the unintended consequence of constraining physicians’ creativity. This has the potential to undermine clinicians’ freedom to reframe their thinking in response to unfolding biological knowledge, a defining feature of academic medicine. In this Perspective, the authors illustrate the confluence of creativity, context, and discovery through a historical example: the evolution of tuberculosis (TB) multidrug chemotherapy as espoused by Walsh McDermott and his colleagues during the 1940s and 1950s.Before the discovery of streptomycin in 1943, clinician–researchers aimed to identify a “magic bullet” that would rapidly eradicate tubercle bacilli from the body. In the years following the discovery of streptomycin, it became clear that the biology of TB did not conform to researchers’ expectations. The recognition that treatment would neither be simple nor quick prompted further attempts to devise an optimal streptomycin regimen, which would enable the host’s immune system to suppress infection and prevent the emergence of streptomycin-resistant strains. By the late 1950s, investigators clarified the limits of streptomycin’s effectiveness, which led to combined chemotherapy. In so doing, they gained a better understanding of drug–bacilli–host interactions and shifted attention from the host to the drug-resistant microbe.The authors argue that this tale of discovery offers a latent lesson for academic medicine: As the health care system undergoes systemic restructuring, it is essential to preserve the freedom to reframe thinking and creatively solve translational problems in research and practice.

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“…2 The rate of spontaneous mutation resulting in resistance to streptomycin (and other drugs) is high enough so that a single drug cannot eradicate all M. tuberculosis organisms in persons with the disease, and over time, resistant organisms will predominate.…”

Section: Introductionmentioning

confidence: 99%

Multi-drug Resistant Tuberculosis in Rajshahi District

Hussain

Haque

Ekram

et al. 1970

TAJ: J of Teachers Assoc

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Multidrug-resistant tuberculosis (MDR TB) is a form of tuberculosis that is resistant to at least INH and rifampicin. Total 4390 new patients with sputum smear positive pulmonary tuberculosis were enrolled in this study and treated with 2HRZE /6HT or HE. 3908 patients were cured and 482 patients had to undergo retreatment because of relapse or treatment failure. Retreatment was done with 2HRZES/1HRZE/5H 3 R 3 E 3. Directly observed therapy was employed to treat all the cases. 18 patients remained sputum smear positive after eight months of treatment. So, the percentage of MDR TB in total study population was observed to be 0.4%.And the percentage of MDR TB among retreatment cases were 3.7%. TAJ 2005; 18(2): 113-117

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Treatment of Tuberculosis With Streptomycin

Cited by 131 publications

References 5 publications

Mechanisms of Aminoglycoside Ototoxicity and Targets of Hair Cell Protection

Mechanisms of Aminoglycoside Ototoxicity and Targets of Hair Cell Protection

Walsh McDermott and Changing Conceptions of Tuberculosis Antibiotic Therapy

Multi-drug Resistant Tuberculosis in Rajshahi District

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