Multi-drug Resistant Tuberculosis in Rajshahi District

Hussain, M Wasim; Haque, Md. Azizul; Ekram, Arm Saifuddin; Hossain, Maruf; Rahman, M Fazlur

doi:10.3329/taj.v18i2.3190

Cited by 3 publications

(2 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In a study by Hussain et al 31 in Rajshahi, Bangladesh showed that the percentage of MDR TB in total study population was 0.4%, the percentage of MDR TB among retreatment cases were 3.7% and some patients remained smear positive even after eight months of treatment. In a study conducted in Bogra district, Bangladesh registered a large number of PTB patients and 13% of them remain smear positive even after 2 years of treatment indicating rapid emergence of drug resistance in TB isolates 29 .…”

Section: Discussionmentioning

confidence: 94%

Prevalence and treatment follow-up of drug-resistant extra-pulmonary tuberculosis in rural communities in Narshingdi, Bangladesh

et al. 2014

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 94%

Prevalence and treatment follow-up of drug-resistant extra-pulmonary tuberculosis in rural communities in Narshingdi, Bangladesh

et al. 2014

View full text Add to dashboard Cite

“…In a study by Hussain et al 32 in Rajshahi, Bangladesh showed that the percentage of MDR TB in total study population was 0.4%, the percentage of MDR TB among retreatment cases were 3.7% and some patients remained smear positive even after eight months of treatment. In a study conducted in Bogra district, Bangladesh registered a large number of PTB patients and 13% of them remain smear positive even after 2 years of treatment indicating rapid emergence of drug resistance in TB isolates 33 .…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Multi-Drug Resistant (MDR) pulmonary tuberculosis in a tertiary care hospital of Narshingdi, Bangladesh

Afroz

Ali²,

Fakruddin

et al. 2013

Int J of Biomed & Adv Res

View full text Add to dashboard Cite

Tuberculosis is a chronic, communicable, granulomatous disease. Most infections in humans result in an asymptomatic, latent infection and about one in ten latent infections eventually progresses to active disease, which, if left untreated, kills more than 50% of those infected. In 2011, an anti-tuberculosis (TB) drug resistance survey in Narshingdi, Bangladesh, enrolled new and retreatment patients. In the study, a number of villages were randomly selected and 264 pulmonary tuberculosis (PTB) patients were identified. All the patients received treatment with standardized first-line drug (FLD) regimens and were investigated to document treatment efficiency. Among the patients, 130 were reported in lower income, 117 in medium income and only 17 in higher income group. Farmers (95%) in low income group, and female housewives (68%) in medium income group were mostly infected. Silicosis and malnutrition were assumed responsible for high PTB cases in farmers and housewives respectively. Males were more prone to PTB and the ratios of male to female patients were found to increase with increasing age. The working youth group (25-34) and older people (above 64) were found most vulnerable. Multi-drug resistant (MDR) TB was detected in both new and retreatment patients. Patients with MDR-TB who had been declared cured with first-line anti-TB treatment had a high rate of TB recurrence and death. The rate of TB recurrence and death was high four years after MDR-TB patients were judged to have been cured. PTB patients in Bangladesh had high recurrence and death rates even after treatment with standardized FLD regimens, reinforcing the need for early survey, diagnosis and treatment, including assessment of treatment outcomes.

show abstract

Prevalence of Antibiotic-Resistant Pulmonary Tuberculosis in Bangladesh: A Systematic Review and Meta-Analysis

et al. 2020

View full text Add to dashboard Cite

Resistance to anti-tuberculosis (anti-TB) antibiotics is a major public health concern for many high-TB burden countries in Asia, including Bangladesh. Therefore, to represent the overall drug-resistance pattern against TB in Bangladesh, a systematic review and meta-analysis was conducted. Databases such as PubMed, Scopus, and Google Scholar were searched to identify studies related to antibiotic-resistant TB. A total of 24 studies covering 13,336 patients with TB were secured and included. The random-effects model was used to calculate the summary estimates. The pooled prevalence of any, mono, multi, poly, and extensive anti-TB antibiotic-resistances were 45.3% [95% CI: 33.5–57.1], 14.3% [95% CI: 11.4–17.2], 22.2% [95% CI: 18.8–25.7], 7.7% [95% CI: 5.6–9.7], and 0.3% [95% CI: 0.0–1.0], respectively. Among any first and second-line anti-TB drugs, isoniazid (35.0%) and cycloserine (44.6%) resistances were the highest, followed by ethambutol (16.2%) and gatifloxacin (0.2%). Any, multi, and poly drug-resistances were higher in retreatment cases compared to the newly diagnosed cases, although mono drug-resistance tended to be higher in newly diagnosed cases (15.7%) than that in retreatment cases (12.5%). The majority (82.6%) of the included studies were of high quality, with most not exhibiting publication bias. Sensitivity analyses confirmed that all outcomes are robust and reliable. It is concluded that resistance to anti-TB drugs in Bangladesh is rampant and fast growing. Therefore, the implementation of a nationwide surveillance system to detect suspected and drug-resistant TB cases, as well as to ensure a more encompassing treatment management by national TB control program, is highly recommended.

show abstract

Multi-drug Resistant Tuberculosis in Rajshahi District

Cited by 3 publications

References 6 publications

Prevalence and treatment follow-up of drug-resistant extra-pulmonary tuberculosis in rural communities in Narshingdi, Bangladesh

Prevalence and treatment follow-up of drug-resistant extra-pulmonary tuberculosis in rural communities in Narshingdi, Bangladesh

Prevalence of Multi-Drug Resistant (MDR) pulmonary tuberculosis in a tertiary care hospital of Narshingdi, Bangladesh

Prevalence of Antibiotic-Resistant Pulmonary Tuberculosis in Bangladesh: A Systematic Review and Meta-Analysis

Contact Info

Product

Resources

About