Treatment of the postoperative recurrence of lung cancer in octogenarians

Yasuda, Manabu; Nagashima, Akira; Haro, Akira; Saitoh, Genkichi

doi:10.1007/s00595-013-0719-x

Cited by 4 publications

(5 citation statements)

References 26 publications

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“…Recently, Yasuda et al reported the treatment outcomes of postoperative recurrence of lung cancer in octogenarians [24]. In that study, the median survival time after recurrence was 538 days in the intensive treatment groups (n = 6), 305 days in the palliative treatment group (n = 14) and 155 days in the supportive care only group (n = 17) [24]. The present results for aggressive treatment are considered to be favorable in comparison with these findings.…”

Section: Discussionsupporting

confidence: 47%

“…The frequency of treatmentrelated death was also not significant between the two groups. Recently, Yasuda et al reported the treatment outcomes of postoperative recurrence of lung cancer in octogenarians [24]. In that study, the median survival time after recurrence was 538 days in the intensive treatment groups (n = 6), 305 days in the palliative treatment group (n = 14) and 155 days in the supportive care only group (n = 17) [24].…”

Section: Discussionmentioning

confidence: 97%

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Post-recurrence survival of elderly patients 75 years of age or older with surgically resected non-small cell lung cancer

et al. 2015

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Section: Discussionsupporting

confidence: 47%

Section: Discussionmentioning

confidence: 97%

Post-recurrence survival of elderly patients 75 years of age or older with surgically resected non-small cell lung cancer

et al. 2015

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“…This critical knowledge gap is largely because cancer registries do not report recurrence or subsequent treatment [19, 20]. This leaves researchers to investigate treatment for recurrent disease in small, single institution studies [3, 21, 22]. For example, active cancer-directed treatment for postoperative NSCLC recurrence ranged from 54% among octogenarians in one Japanese institution [21] to 69% of adult patients in one U.S. institution [3].…”

Section: Introductionmentioning

confidence: 99%

“…This leaves researchers to investigate treatment for recurrent disease in small, single institution studies [3, 21, 22]. For example, active cancer-directed treatment for postoperative NSCLC recurrence ranged from 54% among octogenarians in one Japanese institution [21] to 69% of adult patients in one U.S. institution [3]. Neither study examined factors associated with receipt of treatment for postoperative recurrence.…”

Section: Introductionmentioning

confidence: 99%

Impact of age and comorbidity on treatment of non-small cell lung cancer recurrence following complete resection: A nationally representative cohort study

et al. 2016

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Objective-Older patients with non-small cell lung cancer (NSCLC) are less likely to receive guideline-recommended treatment at diagnosis, independent of comorbidity. However, national data on treatment of postoperative recurrence are limited. We evaluated the associations between age, comorbidity, and other patient factors and treatment of postoperative NSCLC recurrence in a national cohort.Materials and Methods-We randomly selected 9,001 patients with surgically resected stage I-III NSCLC in 2006-2007 from the National Cancer Data Base. Patients were followed for 5 years or until first NSCLC recurrence, new primary cancer, or death, whichever came first. Perioperative comorbidities, first recurrence, treatment of recurrence, and survival were abstracted from medical records and merged with existing registry data. Factors associated with active treatment (chemotherapy, radiation, and/or surgery) versus supportive care only were analyzed using multivariable logistic regression.Results-Median age at initial diagnosis was 67; 69.7% had ≥1 comorbidity. At 5-year followup, 12.3% developed locoregional and 21.5% developed distant recurrence. Among patients with locoregional recurrence, 79.5% received active treatment. Older patients (OR 0.49 for age ≥75 compared with <55; 95% CI 0.27-0.88) and those with substance abuse (OR 0.43; 95% CI 0.23-0.81) were less likely to receive active treatment. Women (OR 0.62; 95% CI 0.43-0.89) and patients with symptomatic recurrence (OR 0.69; 95% CI 0.47-0.99) were also less likely to receive active treatment. Among those with distant recurrence, 77.3% received active treatment. Older patients (OR 0.42 for age ≥75 compared with <55; 95% CI 0.26-0.68) and those with any documented comorbidities (OR 0.59; 95% CI 0.38-0.89) were less likely to receive active treatment.Conclusion-Older patients independent of comorbidity, patients with substance abuse, and women were less likely to receive active treatment for postoperative NSCLC recurrence. Studies to further characterize these disparities in treatment of NSCLC recurrence are needed to identify barriers to treatment.

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“…EGFR-TKI is thought to be useful anti-cancer drug with little burden especially in elderly patient. 20) The role of chemotherapy and radiotherapy in the treatment of lung cancer in octogenarians should be elucidated in the future. Five-year OS was 57.5% in this study which was almost the same survival rate compared to previous reviews.…”

Section: Discussionmentioning

confidence: 99%

Results of Lung Cancer Surgery for Octogenarians

Hino

Murakawa

Ichinose

et al. 2015

ATCS

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Purpose: Growing number of elderly lung cancer patients reflecting a lengthening life span has become a serious problem. Purpose of this study was to elucidate the short and long-term outcome of the surgery for octogenarians, and to evaluate the role of lung cancer surgery for this high age group. Methods: The patients with lung cancer aged 80 years or more who underwent the surgery at our institute from January 1998 through December 2012 were retrospectively analyzed by chart review, and the operative mortality, morbidity and the long-term survival were assessed. Results: Out of a total of 1107 patients with primary lung cancer who received surgery during the study period, 94 were octogenarians (8.5%). Sixty-nine patients (73.4%) had preoperative co-morbidity including hypertension in 50 (53.2%), coincidence of other malignancy in 35 (37.2%), anti-coagulant therapy in 29 (30.9%). Twenty-six patients (27.7%) had major or minor postoperative morbidity, and one (1.1%) died due to bronchopleural fistula. Overall-5-year survival rate was 57.5%. Univariative and multivariative analysis using Cox proportional hazard model revealed that male gender and non-adenocarcinoma histology were significant risk factors for poor prognosis. Conclusion: Gender and histology should be taken into account in preoperative evaluation of indication for lung cancer in octogenarians.

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Treatment of the postoperative recurrence of lung cancer in octogenarians

Cited by 4 publications

References 26 publications

Post-recurrence survival of elderly patients 75 years of age or older with surgically resected non-small cell lung cancer

Post-recurrence survival of elderly patients 75 years of age or older with surgically resected non-small cell lung cancer

Impact of age and comorbidity on treatment of non-small cell lung cancer recurrence following complete resection: A nationally representative cohort study

Results of Lung Cancer Surgery for Octogenarians

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