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FIGURE 1. Computed tomography scans showed metastatic liver metastases (A) before and (B) approximately 5 months after the administration of ceritinib. C and D, Computed tomography and positron emission tomography/computed tomography indicated exacerbation of the hepatic metastases. Scale bar: 1 cm.

It is essential for recurrent NSCLC patients to be examined for the EGFR mutation status. Patients with a positive EGFR mutation status receive significant benefits from EGFR-TKI therapy.

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Combination chemotherapy using gemcitabine with vinorelbine was shown to have moderate activity in Japanese MPM patients pretreated with platinum plus pemetrexed chemotherapy. A further multicenter phase II trial is warranted to confirm the efficacy and safety of this combination treatment.