Treatment of the First COVID-19 Case in Kosovo and Management of the Pandemic

Bojaj, Gazmend; Agahi, Riaz; Hoxha, Ilir

doi:10.52152/spr/2021.118

“…The etiology of RSA is complex and diverse, and in addition to genetic, anatomical abnormalities, endocrine disorders, infections, autoimmunity, sperm quality, lifestyle, psychosomatic, and environmental factors, the etiology of 50%–75% of RSA is still unknown [ 5 ]. The literature [ 6 ] shows that a significant proportion of recurrent spontaneous abortions are associated with immune factors. The HLA gene system is the most complex polymorphic system known in humans, and it has an important influence on the way the human immune system is regulated.…”

Section: Introductionmentioning

confidence: 99%

Study on the Relationship between Unexplained Recurrent Abortion and HLA-DQ Gene Polymorphism

Tang

¹

,

Zhu

²

,

Shu

³

et al. 2022

Computational Intelligence and Neuroscience

View full text Add to dashboard Cite

Objective. The study aimed to investigate the relationship between human leukocyte antigen (HLA-DQB1) gene variants and recurrent miscarriage. Methods. HLA-DQ gene polymorphisms (PCR-SSP) were detected in 50 couples with recurrent miscarriage (URSA group) and 30 couples with normal births (control group) using sequence-specific primer-guided polymerase chain reaction. Results. The frequency of the DQB1 ∗ 0303 allele in the URSA group (21.50%) was substantially higher than that of the control group (11.67%) ( P = 0.0260 0.05, RR = 1.754); however, the frequency of the DQB1 ∗ 0302 allele in the URSA group (4.00%) was substantially lower than that of the control pair (10.00%) ( P = 0.0318 0.05, RR = 0.400); the frequency of sharing one allele was 46.00% (23/50) in the URSA group and 0.00% (0/30) in the normal control group; the frequency of sharing two alleles was 40.00% (2/50) in the URSA group and 43.33% (13/30) in the normal control group, with no significant difference between the two groups. Conclusion. For the Zhejiang population, HLA-DQB1 ∗ 0303 may be a susceptibility gene for recurrent miscarriage, while HLA-DQB1 ∗ 0302 may be protective against recurrent miscarriage, especially for women.

show abstract

“…Given the complex pathogenesis of DN, there is no curative therapy, and most patients require renal replacement therapy [ 7 ]. Diabetic nephropathy is one of the most common microvascular complications, and the lung is a relatively microvascular and collagen-rich organ and therefore vulnerable to diabetic microangiopathy and histone nonglycosylation [ 2 , 8 ]. Alterations in microvascular ultrastructure regulate the thickening of the alveolar capillary endothelial cell matrix, which in turn affects pulmonary ventilation and pulmonary diffusion function [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Impact of Diabetic Nephropathy on Pulmonary Function and Clinical Outcomes

Niu

¹

,

Liu

²

,

Yang

³

et al. 2022

Computational Intelligence and Neuroscience

View full text Add to dashboard Cite

Objective. The main objective is to study the effect of diabetic nephropathy on pulmonary function and clinical outcomes. Methods. The method is to retrospectively analyze patients with diabetic nephropathy (DN) in our hospital from April 2018 to March 2022 as study subjects. The differences in baseline data, serum indicators, renal function indicators, and pulmonary function of patients at different clinical stages were analyzed and then explored. Finally, logistic regression was used to analyze the risk factors affecting patients’ clinical outcomes and to evaluate the diagnostic effects. Results. Baseline information (age, disease duration, BMI, and systolic and diastolic blood pressure), serum indicators (HbA1c, FBG, 2hPG, TG, TC, and LDLC), renal function indicators (CysC, BUN, and Scr), and pulmonary function (TLC, VC, FEV1, FEV1/FVC, MVV, MEF25, MEF50 MEF75, DLCO, and DLCO/VA) were significantly different P < 0.01 ; multiple logistic regression analysis showed that SBP, HbA1c, FBG, 2hPG, BUN, Scr, TLC, VC, FEV1/FVC, MVV, DLCO, and DLCO/VA were all key factors in the development of clinical outcomes in DN P < 0.05 . ROC analysis showed that all of these important factors had an AUC greater than 0.75 for the diagnosis of DN with high sensitivity and specificity. Conclusion. Serum and renal function indices of DN patients gradually increased with stage, accompanied by a decrease in pulmonary ventilation, and diffusion function; SBP, HbA1c, FBG, 2hPG, BUN, Scr, TLC, VC, FEV1/FVC, MVV, DLCO, and DLCO/VA were all key factors affecting the clinical outcome of DN; controlling blood glucose, lipids, improving pulmonary ventilation, and diffusion function can better prevent the occurrence and worsening of DN.

show abstract

“…Relevant studies have shown [7] that drug therapy can repair damaged cornea and maintain structural and functional stability of the eye. Sodium hyaluronate eye drops are used as an external medicine for eye diseases, mainly composed of sodium hyaluronate; when used as a substitute for artificial tears, it can relieve dry eyes and play a lubricant effect; calf blood-deproteinizing extract eye gel mainly consists of 20% calf blood-deproteinizing extract and part of free amino acids, which can improve eye cell function [8,9]. e efficacy of these two drugs is slow, and the clinical efficacy of combined therapy is limited for patients with dry eye disease.…”

Section: Introductionmentioning

confidence: 99%

Effects of Calf Blood-Deproteinized Extract Ophthalmic Gel Combined with Sodium Hyaluronate Eye Drops on Conjunctival Hyperemia Score and Tear Film Stability in Patients with Dry Eye

Wang

¹

,

Zhou

²

,

Sun

³

et al. 2022

Computational Intelligence and Neuroscience

View full text Add to dashboard Cite

Objective. The aim of this paper is to research the impact of calf blood-deproteinized extract ophthalmic gel combined with sodium hyaluronate eye drops on conjunctival hyperemia score and tear film stability in patients having dry eye. Methods. 144 patients having dry eye disease who were hospitalized from July 2018 to July 2021 were chosen as the research targets, which were composed of the control group and research group on the basis of the sequences of hospitalization, and each has 72 cases. The sodium hyaluronate eye drops were gained in the control one. In accordance with the control one, the study ones were given the combined treatment with eye drops of sodium hyaluronate. Treatment of calf blood-deproteinized extract ophthalmic gel, the scores of conjunctival hyperemia, tear film stability, visual function, curative effect, and their adverse reactions were observed and made comparisons among the two groups. Results. After the treatments of 2 weeks and later 1 month, the numerical values of the conjunctival hyperemia were fewer in the categories which had been mentioned above, and in contrast with the control one ( P < 0.05), the numerical values of the conjunctival hyperemia in the study one were distinctly fewer. The data of SIt, BUT, and the heights of the central tear river of the lower eyelid were higher than those before cure. In comparison with the control one, the FL of the study one was distinctly lower, and the heights of SIt, BUT, and the central tear river of the lower eyelid were obviously better than the control one ( P < 0.05). After therapy, the visual contrast sensitivity of the patients in two categories at 6.4 c/d and 12c/d increased in comparison with those before treatment, and the visual contrast sensitivity of the study group at 6.4 c/d and 12c/d was apparently higher than the data of control one ( P < 0.05); the effective rate of treatment in the study one was 97.22%, which had a higher situation than the control one, 88.89% ( P < 0.05); the probability of occurrence of the negative events in the study one after treatment was 4.17%, which was distinctly below the control one, 15.28% ( P < 0.05). Conclusion. In order for the treatments of patients having dry eye disease, the use of calf blood-deproteinized extract ophthalmic gel having the combinations with eye drops of sodium hyaluronate can enhance the extent of visual impairment and conjunctival hyperemia with effect and improve the stability of tear film, with significant safety and high efficiency.

show abstract

Treatment of the First COVID-19 Case in Kosovo and Management of the Pandemic

Cited by 14 publications

References 7 publications

Study on the Relationship between Unexplained Recurrent Abortion and HLA-DQ Gene Polymorphism

Study on the Relationship between Unexplained Recurrent Abortion and HLA-DQ Gene Polymorphism

Impact of Diabetic Nephropathy on Pulmonary Function and Clinical Outcomes

Effects of Calf Blood-Deproteinized Extract Ophthalmic Gel Combined with Sodium Hyaluronate Eye Drops on Conjunctival Hyperemia Score and Tear Film Stability in Patients with Dry Eye

Contact Info

Product

Resources

About