Treatment of Strongyloides Stercoralis Infection with Intravenous Gentian Violet

Browne, Donovan C.; Contacos, Peter G.; Welch, George E.; McHardy, Gordon

doi:10.4269/ajtmh.1957.6.1066

Cited by 7 publications

(2 citation statements)

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“…In the absence of such perfect sanitary conditions, reliance on anti-helminthic drugs is a reasonable option. The treatment of Strongyloides has come a long way since the days when intravenous gentian violet was introduced in 1950 [39] . Currently, three drugs have been approved for the treatment of Strongyloides: Albendazole, Mebendazole and Ivermectin.…”

Section: Treatmentmentioning

confidence: 99%

Strongyloidiasis: A case with acute pancreatitis and a literature review

Makker¹,

Balar²,

Niazi³

et al. 2015

WJG

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Strongyloides stercoralis, a soil transmitted helminth infection, affects millions with varying prevalence worldwide. A large number of affected hosts are asymptomatic. Symptoms pertaining to pulmonary and gastrointestinal involvement may be present. Manifestations of involvement beyond lung and intestine can be seen with dissemination of infection and lethal hyperinfection. Immunosuppression secondary to use of steroids or other immunosuppressants and coexistence of human T-lymphotropic virus type-1 are the known risk factors for dissemination and hyperinfection. Diagnostic modalities comprise stool examination, serology and molecular testing. Stool tests are inexpensive but are limited by low sensitivity, whereas serologic and molecular tests are more precise but at the expense of higher cost. Treatment with Ivermectin or Albendazole as an alternative is safe and efficacious. We present a rare case of acute pancreatitis secondary to Strongyloides. High index of suspicion in patients specifically from endemic countries of origin and lack of other common etiologies of acute pancreatitis may help in early diagnosis and prompt treatment of this potentially fatal infection.

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Section: Treatmentmentioning

confidence: 99%

Strongyloidiasis: A case with acute pancreatitis and a literature review

Makker¹,

Balar²,

Niazi³

et al. 2015

WJG

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“…A recent study found that GV was effective against the protozoa Leishmania , the causative agent of cutaneous leshmaniasis, both in vitro and in vivo in a mouse model . Gentian violet has also been used historically to treat the parasitic nematodes Strongyloides and Enterobium (pinworm) .…”

Section: Additional Antimicrobial Effectsmentioning

confidence: 99%

Gentian Violet: a 19th century drug re‐emerges in the 21st century

Maley

Arbiser

2013

Experimental Dermatology

127

108

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Gentian violet (GV) has a long and varied history as a medicinal agent. Historically used as an anti-bacterial and anti-fungal, recent reports have shown its utility as an anti-typranosomal, anti-viral and anti-angiogenic agent. The objective of this paper is to summarize evidence regarding the efficacy, and safety of GV use in dermatology. Recent discoveries have found novel targets of GV, namely NADPH oxidase in mammalian cells and thioredoxin reductase 2 in bacterial, fungal, and parasitic cells. These discoveries have expanded the use of GV in the 21st century. Given that GV is well tolerated, effective and inexpensive, its use in dermatology is predicted to increase.

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Chemotherapy of Gastrointestinal Nematodiasis in Man

Janssens¹

1985

Chemotherapy of Gastrointestinal Helminths

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Treatment of Strongyloides Stercoralis Infection with Intravenous Gentian Violet

Cited by 7 publications

References 0 publications

Strongyloidiasis: A case with acute pancreatitis and a literature review

Strongyloidiasis: A case with acute pancreatitis and a literature review

Gentian Violet: a 19th century drug re‐emerges in the 21st century

Chemotherapy of Gastrointestinal Nematodiasis in Man

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