Treatment of severe staphylococcal infections with a rifampicin-minocycline association

Clumeck, Nathan; Marcelis, L.; Amiri-Lamraski, M. H.; Gordts, B.

doi:10.1093/jac/13.suppl_c.17

Cited by 42 publications

(24 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The combination tion at 4 hr, but S. epidermidis became resistant to of rifampin with other antibiotics may prevent the derifampin by 18 and 42 hr, with a significant increase velopment of resistance and enhance the efficacy in the MIC. Rifampin activity in the broth remained against graft-adherent bacteria [17,18]. The results of the same at 4, 18, and 42 hr, as determined by sampling this in vitro study need to be analyzed with other the broth from the tubes at each antibiotic concentra-strains of Staphylococcus species, combinations of antition and determining the zone of inhibition against biotics, as well as confirmed with an in vivo study.…”

Section: Resultsmentioning

confidence: 94%

Antibiotic Efficacy againstStaphylococcus epidermidisAdherent to Vascular Grafts

Bergamini

McCurry

Bernard

et al. 1996

Journal of Surgical Research

View full text Add to dashboard Cite

Section: Resultsmentioning

confidence: 94%

Antibiotic Efficacy againstStaphylococcus epidermidisAdherent to Vascular Grafts

Bergamini

McCurry

Bernard

et al. 1996

Journal of Surgical Research

View full text Add to dashboard Cite

“…The rationale for use of rifampicin is that this antibiotic retains its bactericidal activity against staphylococci that adhere to implants, and also reaches elevated intracellular and tissue concentrations. When combined with other antibiotics such as a quinolone, minocycline, or glycopeptides, emergence of resistance to rifampicin may be prevented (Clumeck et al 1984, Chuard et al 1991, Zimmerli et al 1998. These combinations may also be efficacious against methicillin-resistant staphylococci, and they have been shown to be more effective than monotherapy in in vivo experimental models of foreign-body infections with staphyloccoci (Desplaces andAcar 1988, Tarasi et al 2003).…”

Section: Discussionmentioning

confidence: 99%

Risk factors associated with acute hip prosthetic joint infections and outcome of treatment with a rifampinbased regimen

Choong

Dowsey²,

Carr³

et al. 2007

Acta Orthopaedica

128

View full text Add to dashboard Cite

Background and purpose Acute prosthetic infection is a serious problem. We report factors related to the incidence of acute infection and results of combined joint debridement and prolonged rifampicin-based antibiotic therapy.Patients and methods Between 1998 and 2004, 14 acute infections occurred after 819 primary hip arthroplasties. The association between patient-related and surgical factors and the risk of infection were analyzed. Infections were treated with multiple joint lavage, debridement, 2 weeks of antibiotic therapy, and then oral antibiotics for a minimum of 6 months.Results There was a correlation between having a body mass index (BMI) of ≥ 30, and also more than 2 co-morbidities, and an increased risk of infection. Diabetes was a potential risk factor. Following our regime of treatment, 11 of 14 patients retained their prosthesis. 2 of 3 who required resection arthroplasty underwent successful staged revision, while the third patient had no further surgery because of being deemed unfit.Interpretation Primary joint replacement was salvaged in 11 of 14 patients. When successful re-implantation was included, 13 of 14 patients had a mobile prosthetic joint without further infection.

show abstract

“…Unlike heavily contaminated areas such as the gastrointestinal tract, catheters are rarely heavily colonized or exposed to highgrade bacteremia (27). In vitro (24,30) and in vivo (3,5) studies have demonstrated that minocycline protects against the emergence of staphylococcal strains that are resistant to rifampin. In addition, neither rifampin nor minocycline was found to be associated with cross-resistance to other betalactam or glycopeptide antibiotics (7).…”

Section: Discussionmentioning

confidence: 99%

Antibiotics and prevention of microbial colonization of catheters

Raad

Darouiche

Hachem

et al. 1995

Antimicrob Agents Chemother

211

106

View full text Add to dashboard Cite

Slime-producing staphylococci frequently colonize catheters, and when they are embedded in biofilm, they become resistant to various antibiotics. In the study that is described, the comparative efficacies of vancomycin, clindamycin, novobiocin, and minocycline, alone or in combination with rifampin, were tested in an in vitro model of colonization. The model consisted of the modified Robbins device with antibiotic-impregnated cement filling the lumen of catheter segments. The synergistic combination of minocycline and rifampin was the most efficacious in preventing bacterial colonization of slime-producing strains of Staphylococcus epidermidis and Staphylococcus aureus to catheter surfaces. A similar trend was observed when the inhibitory activities of polyurethane catheters coated with minocycline and rifampin were compared with the inhibitory activities of catheters coated with other antimicrobial agents. The inhibitory activities of catheters coated with minocycline and rifampin against S. epidermidis, S. aureus, and Enterococcus faecalis strains, for example, were significantly better than those of catheters coated with vancomycin (P < 0.05). The inhibitory activities of catheters coated with minocycline and rifampin against gram-negative bacilli and Candida albicans were comparable to those of catheters coated with ceftazidime and amphotericin B, respectively. We found that the combination of minocycline and rifampin is unique and highly effective in preventing the colonization of catheters with slimeproducing staphylococci and that it also displays a broad-spectrum inhibitory activity against gram-negative bacteria and yeast cells.Catheters are one of the leading causes of nosocomial infections and primary septicemia (16). Catheter-related infections are most commonly caused by coagulase-positive and coagulase-negative staphylococci, particularly slime-producing strains (1, 2). Because methicillin resistance is very prevalent among Staphylococcus epidermidis organisms and is increasing in frequency among Staphylococcus aureus strains, vancomycin remains the frontline intravenous antibiotic for the treatment of catheter-related bacteremia (12).In developing anti-infective catheters coated with antibiotics, one must avoid such potential limitations as the inhibition of antimicrobial activity by the slime material, the emergence of drug resistance, and superinfection by Candida species. In an in vitro susceptibility study of 197 catheter-related staphylococcal isolates collected between 1983 and 1993 at The University of Texas M. D. Anderson Cancer Center, minocycline, novobiocin, and rifampin were shown to have antimicrobial activities equivalent to those of vancomycin and other glycopeptide antibiotics (21). In the current study, we compared the efficacies of vancomycin, clindamycin, minocycline, novobiocin, and rifampin when used alone and in combination for preventing the microbial colonization of catheters. In addition, catheters coated with either amphotericin B, vancomycin, ceftazidime, or minocycline ...

show abstract

Treatment of severe staphylococcal infections with a rifampicin-minocycline association

Cited by 42 publications

References 0 publications

Antibiotic Efficacy againstStaphylococcus epidermidisAdherent to Vascular Grafts

Antibiotic Efficacy againstStaphylococcus epidermidisAdherent to Vascular Grafts

Risk factors associated with acute hip prosthetic joint infections and outcome of treatment with a rifampinbased regimen

Antibiotics and prevention of microbial colonization of catheters

Contact Info

Product

Resources

About