Treatment of repeated unexplained in vitro fertilization failure with intravenous immunoglobulin: a randomized, placebo-controlled Canadian trial

Stephenson, Mary D.; Fluker, Margo R.

doi:10.1016/s0015-0282(00)01622-8

Cited by 90 publications

(45 citation statements)

References 35 publications

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“…This has been documented in vivo as well as in vitro. The IVIG used in the Stephenson and Fluker trial was provided by Bayer Canada Inc. (4). Figure 2 shows that IVIG preparations cannot be considered equal, and the Bayer Canada preparation was significantly less active than Gammagard that was used for the study in Table II.…”

Section: Discussionmentioning

confidence: 99%

Is intravenous immunoglobulins (IVIG) efficacious in early pregnancy failure? A critical review and meta-analysis for patients who fail in vitro fertilization and embryo transfer (IVF)

Clark

Coulam

Stricker

2006

J Assist Reprod Genet

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Meta-analysis of three published randomized controlled trials (RCTs) of IVIG in IVF failure patients shows a significant increase in the live birth rate per woman (p = 0.012; Number Needed to Treat for 1 additional live birth, NNT = 6.0 women). Using live birth rate per embryo transferred, and adding data from two cohort-controlled trials to the meta-analysis further supports this conclusion (overall p = 0.000015, NNT = 3.7 women). Relevant variables appear to include properties and scheduling of the IVIG, and selection of patients with abnormal immune test results. Different IVIG preparations vary significantly in their ability to suppress NK activity in vitro. A rationale for use of IVIG is provided by a review of mechanisms of IVIG action and mechanisms underlying failure of chromosomally normal embryos.

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Section: Discussionmentioning

confidence: 99%

Is intravenous immunoglobulins (IVIG) efficacious in early pregnancy failure? A critical review and meta-analysis for patients who fail in vitro fertilization and embryo transfer (IVF)

Clark

Coulam

Stricker

2006

J Assist Reprod Genet

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“…A third meta-analysis most recently confirmed the Cochrane conclusion [86], although the exclusion of the two large trials that did not exclude patients with autoimmune diseases [87,88] may have had obvious implications on the data. IVIg appear useful in the management of women with unexplained recurrent failure to conceive following IVF/embryo transfer [89] with pregnancy rates of 56% and 9% in the groups with and without IVIg but a randomized placebo-controlled clinical trial showed no effect, while including two thirds of miscarriages in the presence of karyotype abnormalities [90]. Finally, a meta-analysis [91] of three randomized controlled trials including IVF-failure patients suggested that IVIg significantly increased the live birth rate per woman with the properties and scheduling of IVIg and the selection of patients with abnormal immune tests were relevant variables.…”

Section: Immunoglobulinsmentioning

confidence: 99%

The autoimmune bases of infertility and pregnancy loss

Carp

Selmi

Shoenfeld

2012

Journal of Autoimmunity

195

158

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“…In einer kontrollierten Studie an 51 Patienten konnte kein Benefit für IVIG gegenüber Placebo bezüglich der Implantations-, Schwangerschafts-und Geburtenrate erkannt werden [27].…”

Section: Passive Immunisierungunclassified

Aktive und passive Immunisierung

Kleinstein

2009

Gynäkologische Endokrinologie

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Aktive und passive Immunisierung Leitthema Rezidivierende Implantationsfehler sind ein ungelöstes Problem im Programm der assistierten Reproduktionstechniken. Viele Ursachen können ausgeschlossen werden, es existieren aber weiterhin Unkenntnisse im Bereich der molekularen Präparation des Endometriums vor der Implantation und der genetischen und biochemischen Entwicklung des Embryos. Unklar ist auch, welchen Einfluss die Faktoren innehaben, die eine Sterilität verursachen. Sie können ihren negativen Einfluss fortsetzen, obwohl Follikelreifung, Eizellgewinnung, Befruchtung und Embryotransfer von außen geführt werden. Von großem Interesse ist insbesondere die Immuntoleranz des Embryos, obwohl er semiallogene Eigenschaften besitzt. Auf diese Besonderheit wird im Abschnitt "Immunologie der erfolgreichen Gravidität" eingegangen. Die Idee, eine Immunmodulation auf aktivem oder passivem Weg zur Verbesserung der Implantation zu etablieren, wird im Abschnitt "Therapieempfehlungen" verfolgt. Auf die Schwierigkeiten in der aktuellen Datenlage wird besonders hingewiesen.

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Treatment of repeated unexplained in vitro fertilization failure with intravenous immunoglobulin: a randomized, placebo-controlled Canadian trial

Cited by 90 publications

References 35 publications

Is intravenous immunoglobulins (IVIG) efficacious in early pregnancy failure? A critical review and meta-analysis for patients who fail in vitro fertilization and embryo transfer (IVF)

Is intravenous immunoglobulins (IVIG) efficacious in early pregnancy failure? A critical review and meta-analysis for patients who fail in vitro fertilization and embryo transfer (IVF)

The autoimmune bases of infertility and pregnancy loss

Aktive und passive Immunisierung

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