The autoimmune bases of infertility and pregnancy loss

Carp, Howard; Selmi, Carlo; Shoenfeld, Yehuda

doi:10.1016/j.jaut.2011.11.016

Cited by 195 publications

(170 citation statements)

References 123 publications

(110 reference statements)

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“…rheumatoid arthritis and Sjögren's disease) have a prolonged time to pregnancy (TTP) and a reduction in fertility [11,12]. Autoimmune conditions may affect all stages of fertility such as ovarian failures, implantation failure and pregnancy loss [13].…”

Section: Introductionmentioning

confidence: 99%

Asthma affects time to pregnancy and fertility: a register-based twin study

Gade

Thomsen

Lindenberg³

et al. 2013

European Respiratory Journal

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Coexistence of infertility and asthma has been observed clinically. Therefore, we investigated the association between asthma and delayed pregnancy in a nationwide population-based cohort of twins.A cohort of 15 250 twins living in Denmark (aged 12-41 years) participated in a questionnaire study including questions about the presence of asthma and fertility. Differences in time to pregnancy and pregnancy outcome were analysed in subjects with asthma, allergy and in healthy individuals using multiple regression analysis.Asthma was associated with an increased time to pregnancy, the percentage of asthmatics with a time to pregnancy .1 year was 27% versus 21.6% for non-asthmatics (OR (95% CI) 1.31 (1.1-1.6); p50.009). The association remained significant after adjustment for age, age at menarche, body mass index and socioeconomic status (OR (95% CI) 1.25 (1.0-1.6); p50.05), and was more pronounced in those .30 years of age (32.2% versus 24.9%, OR (95% CI) 1.44 (1.1-1.9); p50.04). Untreated asthmatics had a significant increased risk of prolonged time to pregnancy compared to healthy individuals (OR (95% CI) 1.79 (1.20-2.66); p50.004), while asthmatics receiving any kind of treatment for asthma tended to have a shorter time to pregnancy than untreated asthmatics (OR 1.40; p50.134).Asthma prolongs time to pregnancy. The negative effect of asthma on fertility increases with age and with disease intensity, indicating that a systemic disease characterised by systemic inflammation also can involve reproductive processes. @ERSpublications Asthma prolongs time to pregnancy: the negative effect of asthma on fertility increases with age and disease intensity

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Section: Introductionmentioning

confidence: 99%

Asthma affects time to pregnancy and fertility: a register-based twin study

Gade

Thomsen

Lindenberg³

et al. 2013

European Respiratory Journal

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“…[35] This issue has been recently extensively reviewed. [36] The group of Yehuda Shoenfeld showed a significant increase of several autoantibodies in patients with RSA. [37] Amongst other cues linking autoimmunity and pregnancy failure, it is interesting to quote the work of Mecacci and coworkers that explored the links between the detection of thyroid autoantibodies in the plasma and RSA.…”

Section: Autoimmune Diseasesmentioning

confidence: 99%

Genetic regulation of recurrent spontaneous abortion in humans

Vaiman¹

2015

Biomed J

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Recurrent pregnancy loss, defined as a pregnancy failure occurring before 24 weeks of gestation more than two or three times according to most definitions, is a fertility defect encountered in 1-5% of the patients. This defect is of course of multifactorial origin. Among the possible origins of recurrent pregnancy loss are uterine structural defaults, defective ploidy control of the embryo, defective immunological dialog between the embryo (or the fetus) and the uterus sometimes in relation with immunological disorders (such as autoimmune diseases), thrombophilia, and free radical metabolism imbalance. Numerous studies attempted to correlate variants of genes supposed to be intervening in the different facets of the early maternal-fetal or maternal-embryonic dialog, and eventually modify the outcome of fertilization, leading to success or failure of post-implantation development. The objective of the present review is to portray the major genes and gene polymorphisms studied for their putative association with recurrent pregnancy loss. Most of these genes have been studied as candidate genes for which strong biological arguments were put forward as to their putative involvement in recurrent pregnancy loss. They were mostly studied by genetic analysis, often in various populations of different ethnic origins, throughout the world. Some of these studies were available only in English as abstracts and were nevertheless used if the information was given with enough detail. With the space being too short to depict all the available literature, different major pathways releva nt to the scientific question are presented without any attempt to hide the fact that discordant views often aroused for a given gene. rather attempt to categorize the factors that were analyzed according to their biological functions and summarize their putative effects.

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“…Some research has connected apoptotic processes, plasma CFD, and inflammation [13]. Increased inflammation has also been associated with female infertility [14]; thus, reduction of inflammatory processes may be connected with increased conception rates.…”

Section: Cell-free Dnamentioning

confidence: 99%

Cell-free DNA and telomere length among women undergoing in vitro fertilization treatment

Czamanski-Cohen

Sarid

Cwikel

et al. 2015

J Assist Reprod Genet

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Purpose The current research is aimed at finding potential non-invasive bio-markers that will help us learn more about the mechanisms at play in failed assisted reproduction treatment. This exploratory pilot study examined the relationship between cell-free DNA (CFD) in plasma and telomere length in lymphocytes among women undergoing in vitro fertilization (IVF) and compared telomere length and CFD levels to a healthy control group. Methods Blood of 20 women undergoing IVF was collected at three time points during the IVF cycle. We assessed the relationship between CFD and telomere length as well as controlling for morning cortisol levels. We also collected blood of 10 healthy controls at two time points (luteal and follicular phases of the menstrual cycle) and compared mean telomere length, CFD, and cortisol levels between the IVF patients and healthy controls.Results The results revealed an inverse relationship between CFD levels and telomere lengths at several time points that remained significant even after controlling for cortisol levels. Women undergoing IVF had statistically significant higher levels of CFD and shorter telomeres compared to healthy controls. Conclusions The relationship between telomere length and CFD should be further explored in larger studies in order to uncover potential mechanisms that cause both shortened telomere length and elevated CFD in women undergoing IVF.

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The autoimmune bases of infertility and pregnancy loss

Cited by 195 publications

References 123 publications

Asthma affects time to pregnancy and fertility: a register-based twin study

Asthma affects time to pregnancy and fertility: a register-based twin study

Genetic regulation of recurrent spontaneous abortion in humans

Cell-free DNA and telomere length among women undergoing in vitro fertilization treatment

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