Asthma affects time to pregnancy and fertility: a register-based twin study

Gade, Elisabeth Juul; Thomsen, Simon F.; Lindenberg, Svend; Kyvik, Kirsten Ohm; Lieberoth, Sofie; Backer, Vibeke

doi:10.1183/09031936.00148713

Cited by 46 publications

(70 citation statements)

References 40 publications

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“…This supports previous findings by TATA et al [14] and GADE et al [10] that showed women with asthma have lower fertility rates when older compared with similarly aged women without asthma. These findings could indicate that the severity, the disease progression and the years exposed to low-grade systemic inflammation, have an influence on fertility.…”

Section: Discussionsupporting

confidence: 92%

“…Recently, a registry-based questionnaire study of twins demonstrated that asthma was associated with prolonged time to pregnancy (TTP) and thereby possibly impairs fertility [10]. Additionally, in a more recent study we showed that vascular endothelial growth factor (VEGF) is significantly decreased in the endometrial cavity in women with unexplained infertility and concomitant asthma compared to women without asthma [11].…”

Section: Introductionmentioning

confidence: 87%

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Fertility outcomes in asthma: a clinical study of 245 women with unexplained infertility

Gade

Thomsen

Lindenberg³

et al. 2016

Eur Respir J

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Evidence is increasing of an association between asthma and aspects of female reproduction. However, current knowledge is limited and furthermore relies on questionnaire studies or small populations. In a prospective observational cohort study to investigate whether time to pregnancy, the number of fertility treatments, and the number of successful pregnancies differ significantly between women with unexplained infertility with and without asthma.245 women with unexplained infertility (aged 23-45 years) underwent questionnaires and asthma and allergy testing while undergoing fertility treatment. 96 women entering the study had either a former doctor's diagnosis of asthma or were diagnosed with asthma when included. After inclusion they were followed for a minimum of 12 months in fertility treatment, until they had a successful pregnancy, stopped treatment, or the observation ended.The likelihood of achieving pregnancy was lower in women with asthma compared with those without asthma: median total time to pregnancy was 32.3 months in non-asthmatic women versus 55.6 months in those with asthma, hazard ratio 0.50 (95% confidence interval 0.34-0.74) p<0.001.Women with asthma had fewer successful pregnancies during fertility treatment, 39.6 versus 60.4% ( p=0.002). Increasing age was of negative importance for expected time to pregnancy, especially among asthmatic women (interaction between age and asthma on time to pregnancy, p=0.001). Female asthmatics had a longer time to pregnancy and less often became pregnant than non-asthmatic women. Increasing age reduced the chances of conceiving especially among asthmatic women. The causal relationship between asthma and subfertility remains unclear. @ERSpublications Asthma can be a cause of subfertility: increasing time to pregnancy and decreasing successful number of pregnancies

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 87%

Fertility outcomes in asthma: a clinical study of 245 women with unexplained infertility

Gade

Thomsen

Lindenberg³

et al. 2016

Eur Respir J

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“…One problem is that we were unable to include those without children in this survey. However, asthma has been related to delayed time to pregnancy, but not to childlessness [31]. In the current study, the reported numbers of children were not different between asthmatic and nonasthmatic parents (data not shown).…”

Section: Discussionsupporting

confidence: 52%

Different Severity and Severity Predictors in Early-Onset and Late-Onset Asthma: A Taiwanese Population-Based Study

Chen

Lee

et al. 2015

Respiration

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Background: Late-onset asthma has been shown to be more severe than early-onset asthma in clinic-based studies. However, population-based studies are scarce, and the predictors of severity have been less studied. Objectives: To determine asthma severity and severity predictors regarding age at onset. Methods: A cross-sectional questionnaire survey was conducted among parents of children from 94 schools in Taiwan in 2004. Asthma severity was defined as short-acting β₂-agonist (SABA), inhaled corticosteroid (ICS) and health care use in the last year. Information on age at onset, demographics, heredity and home exposure was collected. Ordered logistic or logistic regression was used for determining the associations between risk factors and severity. Results: Participants aged 26-50 years were included, resulting in 21,057 (67.8%) participants. Among them, 449 reported ever having had physician-diagnosed asthma, and 381 of those subjects answered the question on age at asthma onset. The risks of rescue SABA, ICS and health care use were generally higher among late-onset (13-50 years) than early-onset (0-12 years) asthmatics. Use of SABA and health care increased from childhood-onset, adolescent- or young adult-onset to adult-onset asthma. Allergic rhinitis was positively associated with SABA use (OR, 9.08; 95% CI, 1.06-77.99) and ICS use (OR, 5.08; 95% CI, 1.47-17.52) in early-onset asthma. Dehumidifier use was negatively associated with SABA use (OR, 0.50; 95% CI, 0.29-0.87) and ICS use (OR, 0.38; 95% CI, 0.19-0.78) in late-onset asthma. Conclusions: In adults, late-onset asthma was more severe than early-onset asthma. Severity, as indicated by SABA and ICS use, was positively associated with allergic rhinitis in early-onset asthma and negatively associated with dehumidifier use in late-onset asthma.

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“…In 2014 more than 200 original articles were published in the ERJ: we were proud to release exciting novel information covering the whole spectrum of respiratory medicine, including epidemiology [18], COPD [19][20][21], asthma [22,23], paediatric pulmonology and cystic fibrosis [24,25], tuberculosis and respiratory infections [26,27], sleep medicine [28], pulmonary vascular medicine [29,30], interstitial lung diseases [31], lung function [32] and lung cancer [33].…”

Section: And Some Star Performancesmentioning

confidence: 99%

The ambition of the European Respiratory Journal: chapter 3

Humbert

Dinh-Xuan

Reeves³

et al. 2014

Eur Respir J

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@ERSpublicationsThe ERS's flagship journal is making great headway http://ow.ly/DRPyzAs the title suggests, this is the third New Year "ambition" editorial of the current 5-year European Respiratory Journal (ERJ) editorial cycle. As we approach the half-way point, it is time not only to look back at 2014, but also to take stock of what has been achieved in the past 2 years and to set the agenda for what is still to be done. We will review the objectives we set in the previous editorials [1, 2] and look at some of the exceptional articles published in 2014. This editorial will be broader in scope than the previous two, looking not only at what the ERJ publishes, but also at how it publishes. The production and dissemination of the journal continues to develop, and we would like to highlight some exciting recent and forthcoming developments.

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Asthma affects time to pregnancy and fertility: a register-based twin study

Cited by 46 publications

References 40 publications

Fertility outcomes in asthma: a clinical study of 245 women with unexplained infertility

Fertility outcomes in asthma: a clinical study of 245 women with unexplained infertility

Different Severity and Severity Predictors in Early-Onset and Late-Onset Asthma: A Taiwanese Population-Based Study

The ambition of the European Respiratory Journal: chapter 3

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