2008
DOI: 10.1136/jnnp.2008.149989
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Treatment of refractory neurosarcoidosis with Infliximab

Abstract: Our experience using Infliximab adds to the growing evidence that it may fulfil a useful role in cases of refractory neurosarcoidosis.

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Cited by 66 publications
(29 citation statements)
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“…Several case reports suggest that infliximab, a tumor necrosis-a inhibitor, is useful in cases of spinal cord sarcoidosis refractory to more conservative management (Pritchard and Nadarajah, 2004;Sollberger et al, 2004;Saleh et al, 2006;Santos et al, 2010). Given the extreme rarity of spinal cord sarcoidosis, its overall dismal prognosis with traditional management, and the impressive results reported with infliximab, clinicians should be aware of its potential application to this often disabling disease and consider early treatment.…”
Section: Sarcoidosismentioning
confidence: 99%
“…Several case reports suggest that infliximab, a tumor necrosis-a inhibitor, is useful in cases of spinal cord sarcoidosis refractory to more conservative management (Pritchard and Nadarajah, 2004;Sollberger et al, 2004;Saleh et al, 2006;Santos et al, 2010). Given the extreme rarity of spinal cord sarcoidosis, its overall dismal prognosis with traditional management, and the impressive results reported with infliximab, clinicians should be aware of its potential application to this often disabling disease and consider early treatment.…”
Section: Sarcoidosismentioning
confidence: 99%
“…Infliximab is a chimeric monoclonal antibody that neutralizes the biological activity of TNF-alpha by binding to its soluble and transmembrane forms and inhibiting receptor binding 44 . Evidence for its use came from the finding of elevated TNF-alpha levels in lymph nodes and BAL of patients with sarcoidosis 39 and by the demonstration that it is a crucial cytokine in the establishment and maintenance of inflammation in several autoimmune disorders 44 .…”
Section: Anti-tnf Agentsmentioning
confidence: 99%
“…Evidence for its use came from the finding of elevated TNF-alpha levels in lymph nodes and BAL of patients with sarcoidosis 39 and by the demonstration that it is a crucial cytokine in the establishment and maintenance of inflammation in several autoimmune disorders 44 . There are 23 reports on the use of infliximab for refractory NS, sometimes in association with other immunosuppressive agents, such as CFA or MMF 36,41,45,46 .…”
Section: Anti-tnf Agentsmentioning
confidence: 99%
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“…Nevertheless, there is a large and growing support for its efficacy, though lacking any confirmatory prospective study. Its use may be considered in patients refractory to other medical treatment (Pereira et al 2011, Santos et al 2010, Aksamit 2008. Likewise, thalidomide also has properties that involve tumor necrosis factor-α blockade.…”
Section: Treatmentmentioning
confidence: 99%