Treatment of Recurrent Corneal Erosion and Corneal Edema with Topical Osmotic Colloidal Solution

Pathogenesis and treatment of recurrent erosion.

“…12 Until now therapeutic contact lenses have not been formally assessed in this condition, and they are here seen to be inferior in efficacy and accompanied by a high complication rate. Two previous reports of the use of therapeutic contact lenses in recurrent ulceration from all causes, not specifically MDF dystrophy, suggest a beneficial effect in 30-50%, but neither was a formal trial.…”

Efeito terapêutico do "cross-linking" corneano na ceratopatia bolhosa sintomática

“…Quando este tratamento é inviável do ponto de vista clínico ou não está disponível, métodos conservadores podem ser usados. Dor ocular e defeitos epiteliais podem ser tratados com administração tópica de anti-inflamatórios, lubrificantes e soluções hipertônicas (5)(6) , além do uso de lente de contato terapêutica (7) . Alternativamente, vários tratamentos cirúrgicos têm sido utilizados na CB, incluindo punção do estroma anterior, criopexia (cauterização), recobrimento conjuntival, transplante de membrana amniótica, ceratectomia fototerapêutica por excimer laser (PTK) e ceratoplastia lamelar posterior (3) .…”

Effects of 5% sodium chloride ophthalmic ointment on thickness and morphology of the normal canine cornea

“…Topical glycerin resulted in significantly greater corneal thinning compared with either a colloidal dextran polysaccharide or 5% sodium chloride solutions; however, it was so irritating that it required topical anesthetic prior to its use and few patients tolerated it long‐term. By contrast, colloidal hyperosmotic solutions were found to be well tolerated and effective in treating recurrent corneal erosions . Thus, it is possible that other osmotic agents may be more efficacious in dogs vs humans and investigation of the safety and efficacy of topical glycerin, hypertonic glucose, colloidal hyperosmotic solutions, or sulfacetamide should be evaluated in dogs with normal and edematous corneas.…”