Treatment of Recalcitrant Warts by Contact Immunotherapy Using Diphenylcyclopropenone (Dpcp)

More, Yuvraj E; Khatu, Swapna S; Gokhale, Neeta R; Chavan, Deepali

doi:10.15373/22778179/feb2014/126

Cited by 3 publications

(7 citation statements)

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“…7 In addition to the frequent recurrence, most of the treatment modalities may lead to injury of the nail bed or nail matrix with the possibility of onychodystrophy or nail dyschromia. 8 Intralesional immunotherapy is a promising safe and effective therapeutic option for common and plantar warts with many reported studies in the literature. [9][10][11] On the other hand, studies specifically designed for the treatment of periungual warts with intralesional antigen immunotherapy are very few.…”

Section: Discussionmentioning

confidence: 99%

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Intralesional Antigen Immunotherapy in the Treatment of Periungual Warts

et al. 2021

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Background Intralesional immunotherapy using different types of antigens is considered an effective and safe treatment option for different types of warts. However, there are few studies that illustrate the use of these antigens in the treatment of periungual warts as a distinct type of warts. Objective To evaluate the efficacy and safety of three antigens: measles, mumps, rubella (MMR) vaccine, Candida antigen, and purified protein derivative (PPD) in the treatment of periungual warts. Methods The study included 150 patients who were randomly assigned to 3 groups with 50 patients in each. Each agent was injected intralesionally at a dose of 0.1 mL into the largest wart at 2-week intervals until complete clearance or for a maximum of 5 sessions. Results Complete clearance of warts was observed in 70%, 80%, and 74% in PPD, Candida antigen, and MMR vaccine groups, respectively. There was no statistically significant difference regarding the therapeutic response between the 3 studied groups. Adverse effects were transient and insignificant in the 3 groups. No recurrence of the lesions was reported in any of the studied groups. Conclusions Intralesional antigen immunotherapy seems to be an effective therapeutic option for the treatment of periungual warts.

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Section: Discussionmentioning

confidence: 99%

“…7 In addition to the frequent recurrence, most of the treatment modalities may lead to injury of the nail bed or nail matrix with the possibility of onychodystrophy or nail dyschromia. 8…”

Section: Discussionmentioning

confidence: 99%

Intralesional Antigen Immunotherapy in the Treatment of Periungual Warts

et al. 2021

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“…a) Sensitization phase. 2% of DPCP in acetone 16 was applied to the bottom of the back with a cotton-tipped applicator. 17 As DPCP was reported to cause pain at the site of application, in cases with back pain, DPCP was applied to the arm.…”

Section: Treatmentmentioning

confidence: 99%

“…After sensitization, according to the patient's capacity to trigger a modest inflammatory response, we began therapy with a weekly application of DPCP solutions ranging between 0.001% and 1%. 16 After 6 h, patients were told to clean the area with soap and water. 19 The dose schedule was modified according to the patients' responses or reactions.…”

Section: Treatmentmentioning

confidence: 99%

Effectiveness and safety of topical application of diphenylcyclopropenone versus podophyllin in treatment of genital warts

Halim

Ahmed²,

Eyada

2023

Int J STD AIDS

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Background Many therapeutic modalities are available for treating genital warts; however, the effectiveness of both diphenylcyclopropenone and podophyllin is still controversial. Aim To evaluate the effectiveness and safety of diphenylcyclopropenone and podophyllin in treating genital warts. Methods This study included 57 patients, divided randomly into two groups. Group (A): diphenylcyclopropenone ( n = 29). Group (B): podophyllin 25% ( n = 28). In group (A), sensitization was done with 2% diphenylcyclopropenone. Then, after 1 or 2 weeks, treatment started with a weekly application of diphenylcyclopropenone solutions ranging between 0.001 and 1% until clearance, or for a maximum of 10 sessions. In group (B), podophyllin 25% was applied weekly until clearance or for a maximum of 6 weeks. Results Higher clearance was achieved in group A, with 19 of 29 (65.5%) patients, than in group B, with 9 of 28 (32.1%) ( p-value = 0.004). Also, effectiveness increases with young age in group A. Shorter wart duration was associated with better response in both groups ( p-value = 0.005). No serious adverse effects occurred in either group. No recurrence was detected in group A, while seven patients (77.8%) had recurrence in group B after 1 year of follow up. Conclusion Diphenylcyclopropenone shows a higher success rate than podophyllin in treating genital warts and a lower recurrence rate.

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“…Recurrence is commonly observed. 2 Most treatment options for warts involve the physical destruction of the infected cells, i.e., they are not virucidal. Occlusion Therapy involves the application of antiseptics, steroids, etc., under either wet or dry wrap dressings.…”

Section: Introductionmentioning

confidence: 99%

Treatment of periungual warts: comparison of topical 5% 5-fluorouracil and intralesional purified protein derivative in a South Indian teaching hospital

Durgadevi

Shridharan

2018

Int J Res Dermatol

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Background: Verrucae or warts are common skin lesions caused by the human papilloma virus. Treatment of warts, particularly those in the periungual region is usually difficult, exhibiting resistance. Available conventional treatment modalities offer little hope in curing periungual warts. Thus, there is a need for a simple, reliable, non-expensive treatment for periungual warts. Aim was to determine and compare the efficacy of intralesional immunotherapy using purified protein derivative (PPD) and topical 5-fluorouracil (5-FU) under tape occlusion for the treatment of periungual warts.Methods: In this prospective comparative study, Group 1 (PPD) patients, intralesional injection of PPD is given in a randomly selected lesion every 3 weeks for a maximum of six sittings. For Group 2 (topical 5% 5-FU under tape occlusion), patients are advised to apply 5% 5-FU under occlusion on the lesion(s) selected for study during the night and left for 12 hours. This is done for 3 months. After completion of the treatment and after the declaration of the cure – follow-up is done for the next three months to look for recurrence.Results: Intralesional PPD had a significantly higher cure rate (88%) than that of topical 5-fluorouracil under occlusion (20%). The mean time taken for the resolution of the periungual warts was 6.6 weeks for intralesional PPD compared to 9.8 weeks for topical 5-fu under tape occlusion.Conclusions: The cure rate of intralesional PPD group (88%) was much higher than that of topical 5% 5-fluorouracil under tape occlusion group (20%). In the PPD group, the younger patients responded well and faster. There was no difference in cure rate among age groups in 5 FU group.

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Treatment of Recalcitrant Warts by Contact Immunotherapy Using Diphenylcyclopropenone (Dpcp)

Cited by 3 publications

References 1 publication

Intralesional Antigen Immunotherapy in the Treatment of Periungual Warts

Intralesional Antigen Immunotherapy in the Treatment of Periungual Warts

Effectiveness and safety of topical application of diphenylcyclopropenone versus podophyllin in treatment of genital warts

Treatment of periungual warts: comparison of topical 5% 5-fluorouracil and intralesional purified protein derivative in a South Indian teaching hospital

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