Treatment of Pulmonary Melioidosis with Combination of Trimethoprim and Sulfamethoxazole

Fuller, Maj Philip B.; Fisk, Maj David E.; Byrd, MC Col Richard B.; Griggs, George A.; Smith, Capt Michael R.

doi:10.1378/chest.74.2.222

Cited by 14 publications

(5 citation statements)

References 3 publications

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“…These results are similar to other reported antibiograms (10,18). Although tetracycline or trimethoprim-sulfamethoxazole has been suggested as primary therapy for melioidosis, no satisfactory treatment regimens have been established (15). P. pseudomallei is not only resistant to therapy with many antibiotics but clinically may fail to respond to those drugs to which it is susceptible in vitro (13,26).…”

Section: Onpgsupporting

confidence: 88%

Pseudomonas pseudomallei infection from drowning: the first reported case in Taiwan

Liao¹,

Wu²,

Lee³

et al. 1985

J Clin Microbiol

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We report a case of Pseudomonas pseudomallei infection, in which the patient acquired the bacteria by aspiration of river water after a drowning incident near Manila, the Philippines. The pulmonary form of melioidosis was noted at the onset, but septicemia developed at a later stage. Positive blood cultures were obtained 17 days after the accident. The patient was treated successfully with a combination of amikacin and cephalothin. This is the first report of P. pseudomallei infection documented in Taiwan. Melioidosis, a rapidly fatal granulomatous disease caused by Pseudomonas pseudomallei, was first described by Whitmore and Krishnaswami in 1912 (29). It was observed that human infections with P. pseudomallei occurred almost exclusively in the between latitude 200 north and latitude 20°s outh. It is endemic in Southeast Asia (Indochina) (19). Although Taiwan is very close geographically to this area, no case of melioidosis has been reported. The present report describes the first imported case ofP. pseudomallei infection in Taiwan. Interestingly, the route of infection was neither airborne transmission nor introduction of the bacterium into a skin wound as reported for the majority of the cases (2, 7, 12). The patient acquired the organisms by aspiration of river water, and developed sepsis after a drowning incident near

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Section: Onpgsupporting

confidence: 88%

Pseudomonas pseudomallei infection from drowning: the first reported case in Taiwan

Liao¹,

Wu²,

Lee³

et al. 1985

J Clin Microbiol

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“…Possibly the first such case was described in 1948 66, and several subsequent reports have suggested that infection was probably contracted in the Philippines (55,73,74,94,126,169), although in individuals who have travelled extensively within endemic areas it is often impossible to be certain as to the origin of infection.…”

Section: History and Geographical Distributionmentioning

confidence: 99%

Melioidosis: the tip of the iceberg?

Dance

1991

Clinical Microbiology Reviews

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“…Little is known of the prevalence of melioidosis in the Philippine Islands, although reports of exported cases suggest that the organism must exist there. Possibly the first such case was described in 1948 (66), and several subsequent reports have suggested that infection was probably contracted in the Philippines (55,73,74,94,126,169), although in individuals who have travelled extensively within endemic areas it is often impossible to be certain as to the origin of infection.…”

Section: Introductionmentioning

confidence: 99%

Melioidosis: the tip of the iceberg?

1991

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For nearly 80 years clinical melioidosis has been considered a rare disease. This bacterial infection is caused by Pseudomonas pseudomallei, a saprophyte found in soil and surface water of endemic areas. Consequently, those who have most contact with soil, the rural poor, are likely to be at greatest risk of infection. Since the diversity of clinical manifestations necessitates the isolation and identification of the causative organism for a definitive diagnosis of melioidosis and the population at greatest risk within endemic areas rarely have access to an appropriate level of health care, the disease has probably been underrecognized. Melioidosis is now known to be an important cause of human morbidity and mortality in Thailand, and this may be true throughout Southeast Asia, which is usually regarded as the main endemic area for the disease. In Australia, melioidosis causes a smaller number of human infections, while disease among livestock has important economic and possible public health implications. Sporadic reports of the infection indicate its presence in several other tropical regions: in the Indian subcontinent, Africa, and Central and South America. Clinical melioidosis may be highly prevalent in these areas, but underdiagnosed as a result of a lack of awareness of the clinical and microbiological features of the disease, or simply because of a lack of health care facilities. Furthermore, during the last two decades the importation and transmission of melioidosis within nontropical zones have been documented. The causative organism is not difficult to grow, and modern antibiotics have improved disease prognosis. Further studies are needed to determine the true worldwide distribution and prevalence of melioidosis so that improved therapeutic and preventive measures can be developed and applied.

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Treatment of Pulmonary Melioidosis with Combination of Trimethoprim and Sulfamethoxazole

Cited by 14 publications

References 3 publications

Pseudomonas pseudomallei infection from drowning: the first reported case in Taiwan

Pseudomonas pseudomallei infection from drowning: the first reported case in Taiwan

Melioidosis: the tip of the iceberg?

Melioidosis: the tip of the iceberg?

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