Melioidosis: the tip of the iceberg?

Dance, David A.B.

doi:10.1128/cmr.4.1.52-60.1991

Cited by 37 publications

(47 citation statements)

References 78 publications

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“…Infection can result in a wide spectrum of clinical outcomes, including an asymptomatic state, benign pulmonitis, acute or chronic pneumonia, or fulminant septicemias (Chaowagul et al ., 1989). Furthermore, even after the apparent resolution of acute symptoms, B. pseudomallei infection can persist for decades as a chronic and latent condition where relapse is possible (Dance, 1991). Its aerosol infectivity and significant mobidity and mortality have led to fears that it will be used as a potential bioterrorism agent.…”

Section: Introductionmentioning

confidence: 99%

Caspase-1 dependent macrophage death induced by Burkholderia pseudomallei

Sun

Pervaiz

et al. 2005

Cellular Microbiology

119

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SummaryBurkholderia pseudomallei is the causative agent for melioidosis, an infectious disease endemic in Southeast Asia and northern Australia. Infection can result in a wide spectrum of clinical outcomes, including asymtomatic, acute or chronic conditions. The ability of the bacteria to survive intracellularly within phagocytes and non-phagocytes is postulated to help this pathogen persist in the body during latent chronic conditions. In some Gram-negative bacteria, such as Shigella and Salmonella , the ability to evade macrophage killing involves inducing rapid macrophage cell death. In several of these instances, these bacteria activate cellular caspase-1 to induce cell death, which is increasingly described to exhibit features more characteristic of oncosis than classical apoptosis. We found that B. pseudomallei is also capable of inducing caspase-1 dependent death in macrophages and this process requires a functional bsa Type III Secretion System (TTSS). Bacterial internalization and pore formation in the cell membrane is necessary for death. Furthermore, cell death is accompanied by the release of IL-1 b b b b and IL-18. We believe that this novel description of macrophage death induced by B. pseudomallei could shed light on the pathogenesis of the bacteria in disease.

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Section: Introductionmentioning

confidence: 99%

Caspase-1 dependent macrophage death induced by Burkholderia pseudomallei

Sun

Pervaiz

et al. 2005

Cellular Microbiology

119

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“…In southern Taiwan, including Kaohsiung and Pingtung Counties, there were 79 cases of scrub typhus, 72 of Q fever, 41 of endemic typhus, 23 of leptospirosis, and 12 of melioidosis from 2002 to June 2004 (unpublished data from the Center for Disease Control, Taiwan). The recent emergence of melioidosis and its rarity result in a lack of familiarity with the culture characteristics of B. pseudomallei [25] and clinical alertness for melioidosis. This will cause delays in recognition, identification, diagnosis, and treatment.…”

Section: Discussionmentioning

confidence: 99%

“…This will cause delays in recognition, identification, diagnosis, and treatment. The incidence of melioidosis, known as a great mimicker for its wide spectrum of clinical manifestations [26], could be underestimated due to a lack of awareness of the disease and relatively inaccessible and insufficiently rapid diagnostics in Taiwan, as indicated by the history of melioidosis in Thailand [25].…”

Section: Discussionmentioning

confidence: 99%

Fatal Septicemic Melioidosis in a Young Military Person Possibly Co‐Infected With Leptospira Interrogans and Orientia Tsutsugamushi

Tseng

2005

The Kaohsiung J of Med Scie

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Concurrent melioidosis, leptospirosis, and scrub typhus after rural activities is rarely reported. A 19-year-old previously healthy man had fever onset after 2 weeks of military training. Pneumonia became evident on the fifth day of fever under intravenous penicillin and oral minocycline therapy. Acute respiratory failure developed the next day with shock and acute renal and liver function deterioration, which resulted in death. Blood cultures on the third and fifth days grew Burkholderia pseudomallei. Serology revealed leptospirosis and scrub typhus. The emergence of melioidosis in Taiwan and this death without antibiotic treatment for melioidosis alert us that B. pseudomallei should be included as a possible pathogen of pneumonia and sepsis, especially after rural activities.

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“…Burkholderia pseudomallei, the etiological agent of melioidosis is endemic in Southeast Asia, Northern Australia, Indian subcontinent, Central and South America (Dance, 1991;White, 2003). B. pseudomallei has been classified as a Category B bio-warfare agent by the Centers for Disease Control and Prevention (CDC) owing to its ability to cause high mortality, high infectivity via formation of aerosol and difficulties in diagnosis at early disease stages (Rotz et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

Adhesion and invasion attributes of Burkholderia pseudomallei are dependent on airway surface liquid and glucose concentrations in lung epithelial cells

Mariappan

Thimma

Vellasamy

et al. 2018

Environ Microbiol Rep

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Physiological constituents in airway surface liquids (ASL) appear to impact the adherence and invasion potentials of Burkholderia pseudomallei contributing to recrudescent melioidosis. Here, we investigated the factors present in ASL that is likely to influence bacterial adhesion and invasion leading to improved understanding of bacterial pathogenesis. Six B. pseudomallei clinical isolates from different origins were used to investigate the ability of the bacteria to adhere and invade A549 human lung epithelial cells using a system that mimics the physiological ASL with different pH, NaCl, KCl, CaCl and glucose concentrations. These parameters resulted in markedly differential adherence and invasion abilities of B. pseudomallei to the lung epithelial cells. The concentration of 20 mM glucose dramatically increased adherence and invasion by increasing the rate of pili formation in depiliated bacteria. Glucose significantly increased adherence and invasion of B. pseudomallei to A549 cells, and presence of NaCl, KCl and CaCl markedly ablated the effect despite the presence of glucose. Our data established a link between glucose, enhanced adhesion and invasion potentials of B. pseudomallei, hinting increased susceptibility of individuals with diabetes mellitus to clinical melioidosis.

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Melioidosis: the tip of the iceberg?

Cited by 37 publications

References 78 publications

Caspase-1 dependent macrophage death induced by Burkholderia pseudomallei

Caspase-1 dependent macrophage death induced by Burkholderia pseudomallei

Fatal Septicemic Melioidosis in a Young Military Person Possibly Co‐Infected With Leptospira Interrogans and Orientia Tsutsugamushi

Adhesion and invasion attributes of Burkholderia pseudomallei are dependent on airway surface liquid and glucose concentrations in lung epithelial cells

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