Treatment of Psoriasis

Goeckerman, William H.

doi:10.1001/archderm.1931.01450010455012

Cited by 119 publications

(55 citation statements)

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“…Saltwater bathing may augment the favourable effect by promoting desquamation and consequently the penetra tion of light into the skin. In 1925, Goeckerman [5] introduced a light-therapy regimen using artificial UV sources and topical application of diluted coal tar. This regimen is still used.…”

mentioning

confidence: 99%

UV-B Phototherapy of Psoriasis

Boer¹,

Schothorst²,

Suurmond³

1980

Dermatology

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The effect of ultraviolet-B light provided by TL-12 fluorescent lamps was investigated in 45 patients with psoriasis vulgaris. 33 (73.3%) of the 45 patients showed considerable and rapid improvement during UV-B therapy. The initial (clearing) phase (4 irradiations a week) required an average of 23 irradiations (range: 9–33). During maintenance treatment, irradiation once every 1–5 weeks proved adequate in 64.4% of the patients.

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confidence: 99%

UV-B Phototherapy of Psoriasis

Boer¹,

Schothorst²,

Suurmond³

1980

Dermatology

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“…The manner in wliich our cure differed from that expounded by Goeckerman (1925Goeckerman ( , 1931 is that in the latter a 1-5% coal tar concentration was used with zinc oxide and petrolatum. The original beginning dosage was one minute with a distance of 76 cm.…”

Section: Methodsmentioning

confidence: 87%

Psoriasis

Rossi-Soffar¹

1965

Dermatology

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“…This complex therapeutical regimen has numerous targets in the pathophysiology of psoriasis. The abnormal hyperproliferative capacity of epidermal cells is known to be diminished by this therapy (14,20). In contrast, little is known about the influence of Goeckerman's therapy of psoriasis on angiogenic activity which is abnormal in these patients (3,5).…”

Section: Discussionmentioning

confidence: 99%

CC and CXC Chemokines Patterns in Psoriasis Determined by Protein Array Method Were Influenced by Goeckerman’s Therapy

Piccoli

Andrýs

Borská

et al. 2009

Acta Med. (Hradec Kralove, Czech Repub.)

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Summary: Goeckerman's therapy (GT) of psoriasis is based on daily application of pharmacy grade coal tar on affected skin with subsequent exposure to UV light. The aim of this study was to evaluate the influence of Goeckerman's therapy of psoriasis on the levels of proangiogenic chemokines ENA-78 (CXCL5, Epithelial Cell Derived Neutrophil Attractant-78), GRO alpha (CXCL1, Growth-Related Oncogene), IL-8 (CXCL8, Interleukin-8), MCP-1 (CCL2, Monocyte Chemotactic (Chemoattractant) Protein 1) and RANTES (CCL5, Regulated on Activation of Normal T Cell Expressed and Secreted) in peripheral blood of 22 children's patients with psoriasis. 22 otherwise healthy children serve as a control group. The serum levels of chemokines were determined by commercial membrane protein array technique (RayBiotech, USA). Efficacy of Goeckerman's therapy was delineated by PASI score. Disease activity was significantly diminished by Goeckerman's therapy (p<0.001). Serum levels of GRO alpha and MCP-1 in patients before GT were significantly higher than those measured in healthy blood donors (GRO alpha: p=0.0128 and MCP-1: p=0.0003). Serum levels of GRO alpha, MCP-1 and RANTES were significantly diminished by GT (GRO alpha: p=0.002, MCP-1: p=0.048 and RANTES: p=0.0131). Compared to the healthy controls, serum level of MCP-1 remained significantly increased in psoriasis patients after GT (p<0.0001). In conclusion, we found that the GT of psoriasis influenced the serum levels of proinflammatory and proangiogenic chemokines, especially GRO alpha, MCP-1 and RANTES. It could be the cause for decreased proangiogenic activity which is described after GT of psoriasis.

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Treatment of Psoriasis

Cited by 119 publications

References 1 publication

UV-B Phototherapy of Psoriasis

UV-B Phototherapy of Psoriasis

Psoriasis

CC and CXC Chemokines Patterns in Psoriasis Determined by Protein Array Method Were Influenced by Goeckerman’s Therapy

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