Treatment of premature ejaculation with sertralin

Balbay, Mevlana Derya; Yıldız, Mustafa; Salvarci, Ahmet; Özsan, Özcan; Özbek, Emin

doi:10.1007/bf02550283

Cited by 20 publications

(9 citation statements)

References 7 publications

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“…[24][25][26] Sertraline at daily doses of 25-50 mg has been repeatedly reported to improve not only the ejaculation latency time in men with PE but also the control over ejaculation and sexual satisfaction, as evidenced by open-label and controlled studies that reported subsequent increased frequency of intercourse. [27][28][29] Similar to other types of SSRIs, sertraline reaches Cmax within 4-6 h following administration. On the basis of these findings, the current study used EEG to examine the effects of 50 mg sertraline on cerebral activation 4 h after its administration.…”

Section: Discussionmentioning

confidence: 96%

“…In contrast, higher-frequency oscillatory cortical activity, in the range of 40-60 Hz, is seen in less widely dispersed cell assemblies. 8 The highest frequency band can be analyzed by LORETA as a high-frequency beta band (22)(23)(24)(25)(26)(27)(28)(29)(30). The analysis of this frequency band can be helpful when evaluating neurocognitive functions during various situations.…”

Section: Introductionmentioning

confidence: 99%

“…12 In addition, it has a higher selectivity than fluoxetine and paroxetine for blocking the reuptake of 5-HT. 13 To identify the effects of the SSRI sertraline for treating PE, changes in brain current-source density (CSD) of high-frequency beta bands (22)(23)(24)(25)(26)(27)(28)(29)(30) induced by sertraline administration were investigated during audiovisual erotic stimulation.…”

Section: Introductionmentioning

confidence: 99%

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Effects of sertraline on brain current source of the high beta frequency band: analysis of electroencephalography during audiovisual erotic stimulation in males with premature ejaculation

et al. 2011

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To identify the effects of sertraline, a selective serotonin reuptake inhibitor, for the treatment of premature ejaculation (PE), changes in brain current-source density (CSD) of the high beta frequency band (22-30 Hz) induced by sertraline administration were investigated during audiovisual erotic stimulation. Eleven patients with PE (36.9 ± 7.8 yrs) and 11 male volunteers (24.2 ± 1.9 years) were enrolled. Scalp electroencephalography (EEG) was conducted twice: once before sertraline administration and then again 4 h after the administration of 50 mg sertraline. Statistical nonparametric maps were obtained using the EEG segments to detect the current-density differences in the high beta frequency bands (beta-3, 22-30 Hz) between the EEGs before and after sertraline administration in the patient group and between the patient group and controls after the administration of sertraline during the erotic video sessions. Comparing between before and after sertraline administration in the patients with PE, the CSD of the high beta frequency band at 4 h after sertraline administration increased significantly in both superior frontal gyri and the right medial frontal gyrus (Po0.01). The CSD of the beta-3 band of the patients with PE were less activated significantly in the middle and superior temporal gyrus, lingual and fusiform gyrus, inferior occipital gyrus and cuneus of the right cerebral hemisphere compared with the normal volunteers 4 h after sertraline administration (Po0.01). In conclusion, sertraline administration increased the CSD in both the superior frontal and right middle temporal gyrus in patients with PE. The results suggest that the increased neural activity in these particular cerebral regions after sertraline administration may be associated with inhibitory effects on ejaculation in patients with PE.

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Section: Discussionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effects of sertraline on brain current source of the high beta frequency band: analysis of electroencephalography during audiovisual erotic stimulation in males with premature ejaculation

et al. 2011

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“…Further studies (prospective studies and randomized controlled trials) have confirmed the efficacy of sertraline in the management of PE [Balbay et al 1998;Biri et al 1998;Mendels, 1995]. Duloxetine [Athanasios et al 2007] and Escitalopram [Safarinejad, 2007] have also been shown to be effective in treating PE.…”

Section: Tricyclic Antidepressants (Clomipramine)mentioning

confidence: 99%

Medical therapy for premature ejaculation

Mohee

Eardley

2011

Therapeutic Advances in Urology

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Premature ejaculation (PE) is a common male sexual dysfunction. Advances in PE research have been hampered owing to a nonstandardized definition of PE, until the definition by the International Society of Sexual Medicine (ISSM) in 2009. Once the diagnosis of PE is established through a thorough history, a variety of medical therapies is available, including tricyclic antidepressants, selective serotonin reuptake inhibitors (SSRIs), centrally acting opiates, phosphodiesterase 5 inhibitors and topical desensitizing creams. Most of these treatments increase the intravaginal ejaculation latency time (IELT) and patient satisfaction scores, with the most convincing evidence for SSRIs and topical creams. Daily SSRIs such as paroxetine, although efficacious, do have a substantial and prolonged side effect profile. Dapoxetine, which is a on-demand SSRI, is the only licensed drug for the treatment of PE, increasing IELT by a factor of 2.5 to 3 with limited and tolerable side effects. In the near future, the topical aerosol PSD502 is due to be licensed for the treatment of PE, increasing IELT by up to a factor of 6 but having minimal local and negligible systemic side effects.

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“…From clinical studies, such drugs have certain effects in curing premature ejaculation, but with extremely obvious side effects. In this research, 5 patients exhibited side effects of different levels, including lethargy, dysphoria, bruxism and nausea, which disappeared 2 to 3 days later after drug withdrawal [3][4][5]. For patients suffering renal failure, there is still no report about whether these drugs can be used.…”

Section: Discussionmentioning

confidence: 82%

The Effectiveness of PVP-I on Male Premature Ejaculation

Song¹,

Sun²,

Hou³

et al. 2017

IPJCS

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Introduction: Premature ejaculation (PE) is the most prevalent sexual dysfunction in every country. There are many types of treatment, but the effect was not certain. Here, we introduce a new medicine on PE. Aim:To assess the effectiveness on PVP-I in treating premature ejaculation.Cases and Methods: 31 patients (27 ± 5 years old) suffering premature ejaculation were enrolled into three groups. For Group a, sertraline was adopted; for Group b, PVP-I was used; for Group c, sertraline and PVP-I were both taken. Results:In the contrast of the treatment groups, at 0.05, no statistical discrepancy exists among the groups before treatment, indicating that intra-group statistical discrepancy does not arise. While after treatment, statistical discrepancy emerges between Group a and Group c (t=2.375, P=0.030), showing that the group taking of the drugs may have better effect than the group adopting sertraline only; no statistical discrepancy exists between Group b and Group c (t=-0.197, P=0.845), indicating there does not exist discrepancy between the group taking both drugs and the group taking PVP-I only. Thus, it is predicted that, drug combination has an advantage over taking sertraline only, and achieves an effect close to that by taking PVP-I only.Conclusion: PVP-I separately can increase ILET of patients suffering premature ejaculation.

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Treatment of premature ejaculation with sertralin

Cited by 20 publications

References 7 publications

Effects of sertraline on brain current source of the high beta frequency band: analysis of electroencephalography during audiovisual erotic stimulation in males with premature ejaculation

Effects of sertraline on brain current source of the high beta frequency band: analysis of electroencephalography during audiovisual erotic stimulation in males with premature ejaculation

Medical therapy for premature ejaculation

The Effectiveness of PVP-I on Male Premature Ejaculation

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