Treatment of Phimosis: Structural Analysis of Prepuce in Patients Submitted to Topical Treatment With Betamethasone in Association With Hyaluronidase

Favorito, Luciano A.; Balassiano, Carlos M; Costa, Waldemar S.; Sampaio, F.

doi:10.1016/s0022-5347(08)60640-0

Cited by 2 publications

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“…This enzyme has been used as an adjuvant to increase the absorption and dispersion of injected drugs [ 32 , 40 ], to reduce edema [ 41 , 42 ] and local side effects in tissues [ 32 ], and as a healing-promoting agent for skin lesions [ 43 ]. In 2005, a highly purified recombinant human hyaluronidase (rHuPH20) was approved by the FDA [ 32 , 44 ].…”

Section: Introductionmentioning

confidence: 99%

Arthropod venom Hyaluronidases: biochemical properties and potential applications in medicine and biotechnology

Bordon¹,

Wiezel²,

Amorim³

et al. 2015

J Venom Anim Toxins Incl Trop Dis

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Hyaluronidases are enzymes that mainly degrade hyaluronan, the major glycosaminoglycan of the interstitial matrix. They are involved in several pathological and physiological activities including fertilization, wound healing, embryogenesis, angiogenesis, diffusion of toxins and drugs, metastasis, pneumonia, sepsis, bacteremia, meningitis, inflammation and allergy, among others. Hyaluronidases are widely distributed in nature and the enzymes from mammalian spermatozoa, lysosomes and animal venoms belong to the subclass EC 3.2.1.35. To date, only five three-dimensional structures for arthropod venom hyaluronidases (Apis mellifera and Vespula vulgaris) were determined. Additionally, there are four molecular models for hyaluronidases from Mesobuthus martensii, Polybia paulista and Tityus serrulatus venoms. These enzymes are employed as adjuvants to increase the absorption and dispersion of other drugs and have been used in various off-label clinical conditions to reduce tissue edema. Moreover, a PEGylated form of a recombinant human hyaluronidase is currently under clinical trials for the treatment of metastatic pancreatic cancer. This review focuses on the arthropod venom hyaluronidases and provides an overview of their biochemical properties, role in the envenoming, structure/activity relationship, and potential medical and biotechnological applications.

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Section: Introductionmentioning

confidence: 99%

Arthropod venom Hyaluronidases: biochemical properties and potential applications in medicine and biotechnology

Bordon¹,

Wiezel²,

Amorim³

et al. 2015

J Venom Anim Toxins Incl Trop Dis

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show abstract

“…According to Freitas (6), "Hyaluronidase is an enzyme obtained from bovine testicles that acts on Hyaluronic acid, reducing intercellular viscosity and causing the tissue to become more permeable to the absorption of drugs" (p. 384). Favorito (7) reports that Betamethasone plus Hyaluronidase alters the elastic fi bers in the prepuce-glans mucosa, allowing their separation.…”

Section: Introductionmentioning

confidence: 99%

Topical betamethasone and hyaluronidase in the treatment of phimosis in boys: a double-blind, randomized, placebo-controlled trial

Nascimento¹,

Pereira²,

Silva³

et al. 2011

Int. braz j urol.

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Purpose:To compare the efficacy of three different formulations containing Betamethasone Valerate versus placebo in the topical treatment of phimosis. As a secondary goal, we compared the outcomes after 30 and 60 days of treatment. Materials and methods: Two hundred twenty boys aged 3 to 10 years old with clinical diagnosis of phimosis were enrolled. Patients were randomized to one of the following groups: Group 1: Betamethasone Valerate 0.2% plus Hyaluronidase; Group 2: Betamethasone Valerate 0.2%; Group 3: Betamethasone Valerate 0.1% or Group 4: placebo. Parents were instructed to apply the formula twice a day for 60 days and follow-up evaluations were scheduled at 30, 60 and 240 days after the first consultation. Success was defined as complete and easy foreskin retraction. Results: One hundred ninety-five patients were included at our final analysis. Group 1 (N = 54), 2 (N = 51) and 3 (N = 52) had similar success and improvement rates, all treatment groups had higher success rates than placebo(N = 38). After 60 days of treatment, total and partial response rates for Groups 1, 2 and 3 were 54.8% and 40.1%, respectively, while placebo had a success rate of 29%. Success and improvement rates were significantly better in 60 days when compared to 30 days. Conclusions: Betamethasone Valerate 0.1%, 0.2% and 0.2% in combination with Hyaluronidase had equally higher results than placebo in the treatment of phimosis in boys from three to ten years-old. Patients initially with partial or no response can reach complete response after 60 days of treatment.

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Treatment of Phimosis: Structural Analysis of Prepuce in Patients Submitted to Topical Treatment With Betamethasone in Association With Hyaluronidase

Cited by 2 publications

References 0 publications

Arthropod venom Hyaluronidases: biochemical properties and potential applications in medicine and biotechnology

Arthropod venom Hyaluronidases: biochemical properties and potential applications in medicine and biotechnology

Topical betamethasone and hyaluronidase in the treatment of phimosis in boys: a double-blind, randomized, placebo-controlled trial

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