Treatment of Persistent Facial Postinflammatory Hyperpigmentation With Novel Pulse-in-Pulse Mode Intense Pulsed Light

Park, Ji-Hye; Kim, JungIn; Kim, Won‐Serk

doi:10.1097/dss.0000000000000627

Cited by 25 publications

(21 citation statements)

References 22 publications

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“…IPLS, using several cut‐off filters (550‐, 570‐ and 590‐nm), was found both safe and effective for postburn PIH in one study . A newly developed IPLS was used for facial PIH with good results . One clinical trial investigated the addition of IPL to the standard treatment regimen of a modified Kligman formula [5% hydroquinone (HQ), 3% vitamin C, 0.025% tretinoin, 0.01% triamcinolone] for postburn PIH in 14 patients with altogether 53 lesions.…”

Section: Clinical Indicationsmentioning

confidence: 99%

“…124 A newly developed IPLS was used for facial PIH with good results. 125 One clinical trial investigated the addition of IPL to the standard treatment regimen of a modified Kligman formula [5% hydroquinone (HQ), 3% vitamin C, 0.025% tretinoin, 0.01% triamcinolone] for postburn PIH in 14 patients with altogether 53 lesions. Two IPLS treatments were performed spaced 1 month apart, and the last follow-up was performed 2 months after the last treatment.…”

Section: Recommendationmentioning

confidence: 99%

See 1 more Smart Citation

Laser treatment of hyperpigmented lesions: position statement of the European Society of Laser in Dermatology

Passeron

Genedy

Salah

et al. 2019

Acad Dermatol Venereol

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Background Lasers and intense pulsed light sources (IPLS) are proposed for the treatment of many pigmentary disorders. They are sometimes considered as magic tools able to remove any type of lesions. Although being the best option for several hyperpigmented lesions, they can also worsen some conditions and have potential side‐effects. Objective The aim of this review was to give evidence‐based recommendations for the use of lasers and IPLS in the treatment of hyperpigmented lesions. Methods These recommendations were produced for the European Society of Laser Dermatology by a consensus panel made up of experts in the field of pigment laser surgery. Recommendations on the use of lasers and light treatments were made based on the quality of evidence for efficacy, safety, tolerability, cosmetic outcome, patient satisfaction/preference and, where appropriate, on the experts' opinion. Results Lasers and IPLS are very effective for treating many hyperpigmented lesions such as lentigos, dermal hypermelanocytosis or heavy metal depositions. In the other hand, they have to be considered with great caution for other disorders, such as café au lait macules, melasma or postinflammatory hyperpigmentation. After making the correct diagnosis, if lasers or IPLS are indicated, the optimal wavelengths and parameters will be chosen taking into account the skin phototype, origin and depth of the target pigments. Conclusion Although potentially very effective, lasers and IPLS cannot be proposed for all types of hyperpigmented lesions. In all cases, precise recognition of the disorder is mandatory for choosing between these devices and other therapeutic approaches.

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Section: Clinical Indicationsmentioning

confidence: 99%

Section: Recommendationmentioning

confidence: 99%

Laser treatment of hyperpigmented lesions: position statement of the European Society of Laser in Dermatology

Passeron

Genedy

Salah

et al. 2019

Acad Dermatol Venereol

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“…The approach has been effective in the treatment of melasma110 and postinflammatory hyperpigmentation11. The pulse-in-pulse mode IPL produces multiple micro-second subpulses and intermittent breaks in a single milli-second pulse.…”

Section: Discussionmentioning

confidence: 99%

“…The pulse-in-pulse mode IPL produces multiple micro-second subpulses and intermittent breaks in a single milli-second pulse. It delivers constant high-fluence energy with an on-time and off-time, which prevents a sudden increase in the skin temperature that is high enough to cause breakdown11.…”

Section: Discussionmentioning

confidence: 99%

Morphologic Changes of Zebrafish Melanophore after Intense Pulsed Light and Q-Switched Nd:YAG Laser Irradiation

et al. 2016

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BackgroundRecently, the pulse-in-pulse mode of intense pulsed light (IPL) has been used increasingly for the treatment of melasma.ObjectiveTo observe the morphologic changes in the melanophore in adult zebrafish after irradiation with conventional and pulse-in-pulse IPL and Q-switched Nd:YAG (QSNY) laser.MethodsAdult zebrafish were irradiated with conventional and pulse-in-pulse mode of IPL. The conditions for conventional IPL were 3 mJ/cm2, 560 nm filter, and pulse widths of 7, 20, and 35 msec. The pulse-in-pulse conditions were 3 mJ/cm2 and on-time 1/off-time 2. The QSNY laser was used with the settings of 1,064 nm, 0.4 J/cm2, a 7 mm spot size, and one shot. Specimens were observed using a light microscope, a transmission electron microscope (TEM), a scanning electron microscope (SEM) and a confocal microscope.ResultsAfter conventional IPL irradiation with a 7 msec pulse width, melanophore breakage was observed using light microscopy. Under TEM, irradiation with conventional IPL for 7 msec and pulse-in-pulse IPL induced melanophore thermolysis with vacuolization. However, changes in the melanophore were not observed with 35 msec IPL. Under SEM, unlike the control and QSNY groups, IPL-irradiated zebrafish showed finger-like fusion in the protein structure of scales. Specimens examined by a confocal microscope after conventional IPL irradiation showed a larger green-stained area on TUNEL staining than that after pulse-in-pulse mode IPL irradiation.ConclusionZebrafish irradiated with long pulse-IPL showed no morphologic changes using light microscopy, while morphological changes in melanophores were evident with use of TEM. Pulse-in-pulse mode IPL caused less damage than conventional IPL.

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“…PIH is frequently treated with hydroquinone and sun protection; however, the use of IPL in the treatment of PIH is not well established 113 . Park et al 114 studied 25 dark‐skinned patients (Fitzpatrick skin types III–V) with persistent facial PIH caused by various etiologies. The patients were treated with PIP mode IPL for a total of eight sessions over a period of 12 weeks.…”

Section: Clinical Indications: Vascular and Pigmentarymentioning

confidence: 99%

Intense pulsed light for the treatment of pigmented and vascular disorders and lesions: A review

Fischer

Han

Gade

et al. 2020

Dermatological Reviews

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Background: Intense pulsed light (IPL) technology has evolved since its first introduction to the market in the 1990s. The underlying mechanism, similar to that of lasers, involves selective thermal damage to specific targets. IPL uses flashlamps and bandpass filters to emit pulsed light of adjustable wavelengths, fluences, and pulse durations. These features contribute to its versatility in treating a wide range of dermatological conditions.Aims: The purpose of this review is to highlight the history, mechanisms of action, and clinical applications of IPL in treating pigmented and vascular lesions, and to present a comparison of commonly-used IPL devices available to the market.Materials and Methods: A literature search was conducted using electronic databases (Medline, Pubmed, Embase, CINAHL, EBSCO) and textbooks, in addition to the authors' clinical experience on IPL therapy, and findings are presented here.Results: Studies have demonstrated IPL to be an efficacious and safe modality for treating a variety of pigmented and vascular disorders and lesions, including postinflammatory hyperpigmentation, melasma, ephelides and solar lentigines, telangiectasias, port-wine stains, poikiloderma of Civatte, rosacea, hemangiomas, venous malformations, and is comparable to other standard therapeutic options.Literature is supportive yet limited due to small sample sizes and short follow-up periods.Discussion: The adaptability and affordability of IPL often deem it a favorable primary or adjunctive option for treating benign pigmented and vascular skin lesions. IPL technology has evolved over time and modern devices are similar in both efficacy and side effect profile.

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Treatment of Persistent Facial Postinflammatory Hyperpigmentation With Novel Pulse-in-Pulse Mode Intense Pulsed Light

Abstract: The pulse-in-pulse mode IPL treatment is effective and safe for persistent facial PIH in dark-skinned patients.

Cited by 25 publications

References 22 publications

Laser treatment of hyperpigmented lesions: position statement of the European Society of Laser in Dermatology

Laser treatment of hyperpigmented lesions: position statement of the European Society of Laser in Dermatology

Morphologic Changes of Zebrafish Melanophore after Intense Pulsed Light and Q-Switched Nd:YAG Laser Irradiation

Intense pulsed light for the treatment of pigmented and vascular disorders and lesions: A review

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