Treatment of Peripheral Arterial Occlusion by Streptokinase Perfusion

Thrombolytic Therapy with Streptokinase Using a Standard Dosage Scheme

“…Based on published results of eight investigators Deutsch and Fischer, 1960;Deutsch et al, 1961 Stacher andBoechnel, 1961 ;Nilsson and Olow, 1962 ;Olow, 1962Olow, , 1963McNicol et al, 1963 ;Helle, 1963 ;Winckelmann and Heimeyer, 1964 ;Abastado, 1964) it was found that the titrated initial dose may vary fromn 25,000 units of S.K. in one individual to 1,500,000 units in another.…”

Anticoagulant and Thrombolytic Drugs1 II

“…The feasibility of thrombolytic therapy in the dissolution of thrombus causing peripheral arterial occlusions has been demonstrated by arteriography (Verstraete et al, 1963;McNicol and Douglas, 1964). Surgery should be used, however, to restore the patency of major arteries where the danger of tissue necrosis exists because of the delay occasioned by the use of thrombolytic agents.…”

Arterial Occlusion Treated with Streptokinase

“…It may be that a haemolytic type of anaemia is usually present in this disease. However, no THE PLASMINOGEN activator streptokinase was first given intravenously to human volunteers by Tillett, Johnson and McCarty (1955) and subsequently has been used as a thrombolytic agent, case reports having recently been published in British journals (Cotton, Flute and Tsapogas, 1962;McNicol, Reid, Bain, and Douglas, 1963;Verstraete, Amery and Vermylen, 1963). Streptokinase may be administered by one of two methods; either intravenous infusion starting with a calculated loading dose, thus providing a high level of streptokinase throughout the circulation, or by local infusion into the affected artery proximal to the actual occlusion.…”