Treatment of periorbital hyperpigmentation

Gendler, Ellen C.

doi:10.1016/j.asj.2005.09.018

Cited by 30 publications

(22 citation statements)

References 6 publications

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“…[2] stated that some medical problems that may contribute to dark circles include disorders of heart, thyroid, kidney or liver, Vitamin K deficiency, Addison's disease, etc., However, statistical data was not shown in this literature. According to Boxrud et al .…”

Section: Discussionmentioning

confidence: 99%

Periorbital hyperpigmentation: A study of its prevalence, common causative factors and its association with personal habits and other disorders

2014

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Background:Periorbital hyperpigmentation (POH) is one of the most commonly encountered conditions in routine dermatology practice. There are only few published studies about its prevalence, classification, and pathogenesis but none showing its association with habits, and other medical conditions in Indian patients.Aims:To determine prevalence and type of POH, common causative factors, and its association with personal habits and other disorders within various age and sex groups.Materials and Methods:Two hundred patients attending the dermatology OPD were included in study and were subjected to detailed history, careful clinical and Wood's lamp examination, eyelid stretch test and laboratory investigations. Clinical photographs of all patients were taken.Results:POH was most prevalent in 16-25 years age group (47.50%) and in females (81%) of which majority were housewives (45.50%). Commonest form of POH was constitutional (51.50%) followed by post inflammatory (22.50%). Lower eyelids were involved in 72.50%. Grade 2 POH was seen in 58%. Wood's lamp examination showed POH to be dermal in 60.50%. Faulty habits were observed viz. lack of adequate sleep (40%), frequent cosmetic use (36.50%), frequent eye rubbing (32.50%), and lack of correction for errors of refraction like myopia in 12% patients. Strong association of POH with stress (71%), atopy (33%) and family history (63%) was noted.Conclusions:Periorbital hyperpigmentation is a multi-factorial entity. It is absolutely essential to classify the type of POH and determine underlying causative factors in order to direct appropriate measures for better and successful outcome in future.

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Section: Discussionmentioning

confidence: 99%

Periorbital hyperpigmentation: A study of its prevalence, common causative factors and its association with personal habits and other disorders

2014

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“…That is why there is no treatment of choice for PODC; in truth, published research are still deficient with regard to this problem [15,16] . Chemical peeling is a simple in-office procedure that has evolved over the years.…”

Section: Discussionmentioning

confidence: 99%

Treatment of Periorbital dark circles: Comparative study of chemical peeling with a combination of trichloroacetic acid and lactic acid versus carboxytherapy

Hassan¹,

Aldalies²,

Maghraby³

2016

J Surg Dermatol

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Periorbital dark circles (PODC) are a common worldwide cosmetic problem. It is difficult to treat due to complications in its pathogenesis and aetiology. Available lines of treatment for PODC include whitening creams, topical retinoid acid, chemical peeling, laser therapy, carboxytherapy, autologous fat transplantation, injectable fillers and surgery (blepharoplasty).The aim of this study isto evaluate and compare the efficacy of chemical peels using trichloroacetic acid (3.75%) and lactic acid (15%) in a gel formula with that of carboxytherapy, in the treatment of periorbital hyperpigmentation.Two groups of patients with PODC were included in the study, named Group A and B in which each group consisted of 15 patients. Group A was assigned for patients who received treatment with chemical peeling with a combination of trichloroacetic acid (3.75%) and lactic acid (15%) in a gel formula, once a week for four weeks. Group B was assigned for patients who received carboxytherapy that was performed by subcutaneous and intradermal injection of CO 2 once a week for four weeks. All patients were assessed by digital photographs, before and after treatment, by observing the improvement in the grade of PODC. Reports of patient satisfaction and global tolerance were evaluated by three medical observers. There was a significant improvement in the grade of PODC in both groups. The degree of improvement of PODC in group A was excellent, with good grade in 93.4% of the treated patients while fair grade in 6.6% of them. There was a statistically significant improvement in the pigmented type. The degree of improvement of PODC in group B was excellent, with good grade in 86.7% of the treated patients while fair grade in 13.3% of them. However, no statistically significant difference between the two groups was observed. Minimal and transient side effects were noticed; however, it did not require further treatment. In conclusion, the two methods of treatment were effective in the treatment of PODC, with the improvement of PODC observed from the first treatment session with both chemical peeling and carboxytherapy.

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“…The activity of the acid was probably related to the 11b-hydroxysteroid dehydrogenase block type 1 at the level of fat cells. It is therefore possible that GA may be used Hyperpigmentation Inhibition of tyrosinase [30]…”

Section: Applications Of 18b-glycyrrhetinic Acid For Skin Disordersmentioning

confidence: 99%

18β‐Glycyrrhetinic acid: its core biological properties and dermatological applications

Kowalska

Kalinowska-Lis

2019

Intern J of Cosmetic Sci

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Recently, attention has been focused on identifying natural herbal compounds with high biological activity, especially antioxidative, anti‐inflammatory and antimicrobial properties, for preventing and controlling various skin conditions, including inflammation‐related diseases such as atopic dermatitis and UV‐induced skin photoaging. One key active plant ingredient is 18β‐glycyrrhetinic acid (GA), the main metabolite of glycyrrhizin (GL), obtained from licorice root. The review examines the valuable biological properties of GA, particularly those playing key roles in the treatment of various dermatological disorders in humans. The review highlights the key anti‐inflammatory, antioxidant and antimicrobial properties of GA and its toxicity towards normal cells lines. It also examines the physicochemical properties of GA and presents methods of increasing its penetration through the stratum corneum and bioaccumulation with the use of modern delivery systems such as liposomes and nanoemulsions.

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Treatment of periorbital hyperpigmentation

Cited by 30 publications

References 6 publications

Periorbital hyperpigmentation: A study of its prevalence, common causative factors and its association with personal habits and other disorders

Periorbital hyperpigmentation: A study of its prevalence, common causative factors and its association with personal habits and other disorders

Treatment of Periorbital dark circles: Comparative study of chemical peeling with a combination of trichloroacetic acid and lactic acid versus carboxytherapy

18β‐Glycyrrhetinic acid: its core biological properties and dermatological applications

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