Treatment of periorbital dark circles: Comparative study of carboxy therapy vs chemical peeling vs mesotherapy

Ahmed, Naglaa A.; Mohammed, Salma S; Fatani, Mohammad I.

doi:10.1111/jocd.12536

Cited by 35 publications

(29 citation statements)

References 14 publications

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“…Postinflammatory hyperpigmentation: Scratching of skin around the eyes, atopic, and allergic contact dermatitis can cause accumulation of fluid under the eye leading to POH. 4. Superficial location of vasculature: The lower eyelids have the presence of overlying blood vessels and thin skin.…”

Section: Extension Of Pigmentary Demarcation Lines Of Face: Pigmentarymentioning

confidence: 99%

“…The use of topical formulations containing depigmenting actives is the main therapeutic strategy used in the management of POH 1 . Synthetic depigmenting agents such as hydroquinone and kojic acid are highly effective, however, long‐term exposure raises several safety concerns (atrophy, carcinogenesis, contact dermatitis, and other local and systemic side effects); and nature‐derived depigmenting actives such as arbutin, niacinamide, yeast derivatives, and polyphenols have been reported to inhibit melanogenesis without melanocytotoxicity 4 . This study presents an overview of the application of natural extracts and nature‐derived actives in the topical treatment of POH along with relevant clinical trial findings and in vitro screening results supporting their efficacy.…”

Section: Introductionmentioning

confidence: 99%

“…1 Synthetic depigmenting agents such as hydroquinone and kojic acid are highly effective, however, long-term exposure raises several safety concerns (atrophy, carcinogenesis, contact dermatitis, and other local and systemic side effects); and nature-derived depigmenting actives such as arbutin, niacinamide, yeast derivatives, and polyphenols have been reported to inhibit melanogenesis without melanocytotoxicity. 4 This study presents an overview of the application of natural extracts and loss of fat with bony prominence. 2 Postinflammatory type (38.31%) is the most common type of POH found in America and European countries, and vascular type (42.3%) is the most common type of POH in the African and Asian countries.…”

mentioning

confidence: 99%

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Management of periorbital hyperpigmentation: An overview of nature‐based agents and alternative approaches

Sawant

Khan

2020

Dermatologic Therapy

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Periorbital hyperpigmentation (POH) is a common dermatological condition that presents as dark periorbital area beneath the lower eyelids, and it is commonly found in females belonging to the age group of 16 to 45 years. The data presented in this review include studies conducted on patients with a clinical/histological diagnosis of POH or melasma. Many diverse topical depigmenting agents comprising an array of naturally obtained actives such as arabinoxylans, α‐arbutin, asiaticoside, azelaic acid, beta‐carotene, boswellic acid, caffeine, chrysin, curcumin, cyanidin‐3‐glucoside, d‐glucoronic acid, dihydrochalcone, dipalmitoyl‐hydroxyprolene, fucoxanthin, genistein, glabridin, b‐glucogallin, hyaluronic acid, lactic acid, lycopene, niacinamide, pycnogenol, retinol, salidroside, and xymenynic acid demonstrated significant benefits in the management of POH. An exhaustive literature search revealed that other techniques such as blepharoplasty, carboxytherapy, calcium hydroxylapatite fillers, tear trough implant, Q‐switched ruby laser, medicated tattoo, fat transfer, micro‐needling, chemical peels, nitrogen plasma skin regeneration, intense pulsed light, and radiofrequency have been evaluated and reported to be beneficial in the treatment of POH. The use of topical depigmenting agents is the most widely reported method in the clinical management of POH. Of these, α‐arbutin, caffeine, cyanidin‐3‐glucoside, and dihydrochalcone are reported to exhibit significant benefits. Combination products containing a blend of actives are reported to be better than single active containing products. This review aims to provide a comprehensive perspective on the role of several topical actives in the modulation of melanin and tyrosinase biosynthesis pathway involved in the complex pathophysiology of POH. It also presents the advantages of combination products and other alternative therapies used in the management of POH.

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Section: Extension Of Pigmentary Demarcation Lines Of Face: Pigmentarymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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Management of periorbital hyperpigmentation: An overview of nature‐based agents and alternative approaches

Sawant

Khan

2020

Dermatologic Therapy

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“…A few studies have investigated the efficacy of PRP in the treatment of infraorbital dark circles. [5][6][7] Although the current studies have positive results, they could not aim to evaluate the change in the quality of life in those patients. In our study, we aimed to discuss our results of PRP procedure in the treatment of infraorbital dark circles using objective scales based on patient satisfaction and the quality of life.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of platelet-rich plasma on infraorbital dark circles by using the FACE-Q scales

Özer

Çolak

2019

Int J Res Dermatol

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Background: Infraorbital dark circles, also referred to as idiopathic cutaneous hyperchromia of the orbital region, periorbital melanosis, periorbital hyperpigmentation or infraorbital pigmentation, is a common condition frequently observed in dark-skinned patients, but has little data in scientific literature. We aimed to discuss our results of PRP procedure in the treatment of infraorbital dark circles using objective scales based on patient satisfaction and the quality of life.Methods: Between 2016 and 2017, 9 patients complaining of infraorbital darkness were included who underwent 3 sessions of platelet-rich plasma injection. The outcome was determined by the difference in pre- and post- procedure FACE-Q modules which were designed as patient-reported outcome instrument to evaluate the unique outcomes of patients undergoing facial cosmetic procedures. Surveys conducted were modules of satisfaction with facial appearance, satisfaction with skin, psychological function, social function, aging appearance appraisal and satisfaction with outcome.Results: All patients were followed up a minimum of 9 months. No major complications were recorded. Only transient ecchymosis and edema were seen in all patients who were improved during follow-up. The patient-reported FACE-Q satisfaction and FACE-Q quality of life pre- and post- procedure results showed statistically significant improvement (<0.05). Overall satisfaction with outcome was 83.33±16.25 (range 63–100).Conclusions: PRP as a potent source of growth factors, can be seen as a safe, biocompatible, autologous and appropriate treatment modality for the dark eye circles formed in lower eye regions which can increase the quality of patients’ lives in terms of social and psychological function.

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“…It was first introduced by Pistor in 1958. 5 The goal of mesotherapy is to delay and improve the skin changes caused by aging. 6 It is a minimally invasive procedure that involves simultaneous injection of small amounts of hyaluronic acids, vitamins, antioxidants, enzymes, and humectants into the subcutaneous layer to stimulate the biosynthetic ability of fibroblasts and to provide an optimal physiologic environment for fibroblasts to increase collagen and elastin syntheses and supply basic active molecules.…”

Section: Introductionmentioning

confidence: 99%

Facial Rejuvenating Effects of Mesotherapy Using a New Polycomponent Formulation

et al. 2018

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Background and Objectives Facial rejuvenation via mesotherapy using a new polycomponent formulation was employed to improve skin texture. In this study, we evaluated the rejuvenating effects of a new polycomponent formulation through mesotherapy using a microneedle therapy system (MTS). Materials and Methods Twenty patients underwent a series of facial procedures, including three sessions performed at 2-week intervals and two sessions at 4-week intervals. Subsequently, 3 mL of new polycomponent formulation was applied to the entire face and MTS was used. Patient satisfaction scoring was conducted by three plastic surgeons who evaluated the improvement of fine wrinkles, skin tightness, hydration, and sweat pore size. In addition, photographs of the patients were taken at each visit and 2 months after the last treatment session. Results The patients were satisfied with the therapeutic outcomes. The scores of the surgeons for the improvement of fine wrinkles, skin tightness, hydration, and sweat pore size were high. Conclusion Minimally invasive mesotherapy using a new polycomponent formulation can improve the clinical appearance of facial skin. However, a largerscale and well-controlled investigation of the clinical efficacy and safety of this technique is needed to confirm these findings.

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Treatment of periorbital dark circles: Comparative study of carboxy therapy vs chemical peeling vs mesotherapy

Abstract: All 3 treatment modalities were effective in the reduction in periorbital pigmentation. However, mesotherapy showed a significant improvement in pigmentation and a higher level of patient satisfaction compared with the other types of treatment.

Cited by 35 publications

References 14 publications

Management of periorbital hyperpigmentation: An overview of nature‐based agents and alternative approaches

Management of periorbital hyperpigmentation: An overview of nature‐based agents and alternative approaches

Evaluation of platelet-rich plasma on infraorbital dark circles by using the FACE-Q scales

Facial Rejuvenating Effects of Mesotherapy Using a New Polycomponent Formulation

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