Facial Rejuvenating Effects of Mesotherapy Using a New Polycomponent Formulation

Abstract

Background and Objectives Facial rejuvenation via mesotherapy using a new polycomponent formulation was employed to improve skin texture. In this study, we evaluated the rejuvenating effects of a new polycomponent formulation through mesotherapy using a microneedle therapy system (MTS). Materials and Methods Twenty patients underwent a series of facial procedures, including three sessions performed at 2-week intervals and two sessions at 4-week intervals. Subsequently, 3 mL of new polycomponent formulation was applied to the entire face and MTS was used. Patient satisfaction scoring was conducted by three plastic surgeons who evaluated the improvement of fine wrinkles, skin tightness, hydration, and sweat pore size. In addition, photographs of the patients were taken at each visit and 2 months after the last treatment session. Results The patients were satisfied with the therapeutic outcomes. The scores of the surgeons for the improvement of fine wrinkles, skin tightness, hydration, and sweat pore size were high. Conclusion Minimally invasive mesotherapy using a new polycomponent formulation can improve the clinical appearance of facial skin. However, a largerscale and well-controlled investigation of the clinical efficacy and safety of this technique is needed to confirm these findings.

Employing hyaluronic acid‐based mesotherapy for facial rejuvenation

“…In most of the studies, serial micropuncture technique was used for injection. Others had used Nappage (picotage), depot and micro‐linear technique 1–34 . One study revealed significantly better improvement with Juvederm hydrate in biophysical measurements including anisotropy, hydration, and skin roughness along with high patients satisfaction with depot technique (mid‐to‐deep dermis injection) compared to picotage technique (superficial dermal injection) 15 .…”

“…10 Biophysical measurements and colorimetry showed improvement in both superficial and deep skin hydration, erythema, PH of skin, and sebum produc tion. [1][2][3][6][7][8][9]11,12,14 Histological and ultrasound evaluation confirmed clinicopathological and biophysical improvements was confirmed to continue up to 3 months by some studies. [1][2][3][6][7][8][9]11,12,14 In contrast, four studies revealed no significant improvement in clinical or histological features of skin with different compounds of mesococktail.…”

“…[1][2][3][6][7][8][9]11,12,14 Histological and ultrasound evaluation confirmed clinicopathological and biophysical improvements was confirmed to continue up to 3 months by some studies. [1][2][3][6][7][8][9]11,12,14 In contrast, four studies revealed no significant improvement in clinical or histological features of skin with different compounds of mesococktail. Although electron microscopy showed neocollagenesis of smaller caliber collagen fibers, but the result was not statistically significant.…”

“…HA, a glycosaminoglycan polymer, is the main material of ECMP that has the ability to absorb water up to approximately 500–1000 times of its weight. With aging process, it gradually declines thus, skin becomes dry and loses its turgor and viscoelastic properties 1–34 …”

“…Non‐cross‐linked (non‐stabilized) HA and cross‐linked HA with low G' (elasticity) and G" (viscosity) have been used via mesotherapy technique for skin rejuvenation and restoring. They have the advantage of excellent fluidity that leads to easy employing, and the main drawback of them is short‐term effect due to degradation by hyaluronidase and ROS 1–34 …”