Treatment of Periodontal Endosseous Defects With Platelet‐Rich Plasma Alone or in Combination With Demineralized Freeze‐Dried Bone Allograft: A Comparative Clinical Trial

Abstract

Within its limits, this study demonstrates that both PRP and PRP combined with DFDBA resulted in significant clinical and radiographic improvement in human periodontal endosseous defects at 6 months, and the addition of DFDBA to PRP did not significantly enhance the treatment outcome.

A clinical and radiographic evaluation of the management of periodontal osseous defects with alloplast and platelet rich plasma

“…Histomorphometric analysis revealed a higher percentage of bone contact in cases where PRP was used in conjunction with bone graft [33]. Some authors showed that the filling with a PRP gel alone achieved a similar bone regeneration than the use of a membrane for guided tissue regeneration [46,47] or even than the filling with a bone substitute [48]. However, other authors demonstrated that PRP alone was not able to support a significant bone regeneration [25] and that PRP should be associated to other materials in order to give good results for the healing of periodontal lesions [49].…”

Comparative Evaluation of Platelet-rich Plasma and Guided Tissue Regeneration Membrane in the Healing of Apicomarginal Defects: A Clinical Study

“…The percentage of defect fill did not significantly differ between the PRP and PRP + DFDBA groups in periodontal endosseous defects (31). Grafts are not capable of recruiting mesenchymal stem cells in the bone marrow or endosteum and osteoprogenitor cells in the periosteum to form a new connective tissue attachment because they are neither osteogenic nor osteoinductive (13).They also interfere with the osteoblastic penetration of the site by creating a physical barrier (10).…”

“…It has been postulated that the barrier may supply support to the replaced tissue, thus facilitating healing, and may protect the blood clot and its adherence to the root surface. It takes several weeks before the root surface-gingival flap interface reaches sufficient maturity to withstand tissue manipulation (31). The coagulum stabilization may be responsible for preventing apical migration of the junctional epithelium, allowing undisturbed wound maturation and repair (8,32).…”

The effect of platelet-rich plasma (PRP) combined with a bone allograft on human periodontal ligament (PDL) cells

“…In the present study, the addition of DFBA to the PRPs did not show a further increase of the PDL cell proliferation, implying that the presence of the graft helps PRP to remain into the defect site enhancing the healing process (Thor et al 2005;Markou et al 2009). …”